[PDF] Top 20 Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome
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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome
... of 19S subunits increases the levels of active 20S proteasomes and protects cancer cells from proteasome ...HepG2 cells were infected with 80 shRNAs targeting 20 different ... Voir le document complet
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Analysis of the proteasome-autophagy crosstalk under proteotoxic stress conditions in acute myeloid leukemia
... autophagy flux. Bz-mediated degradation of 20S or 19S subunits was blocked by VT even if the Bz-mediated degradation of 19S subunits was more prominent than 20S subunits ...C). The ... Voir le document complet
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Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia
... autophagy flux. Bz-mediated degradation of 20S or 19S subunits was blocked by VT even if the Bz-mediated degradation of 19S subunits was more prominent than 20S subunits ...C). The ... Voir le document complet
24
Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients.
... with the needle or by an open surgical procedure from OPMD patients and family members as well as from anonymous age-matching healthy individuals that gave informed ...consent. The pre- sence ... Voir le document complet
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Evidence for the Existence in Arabidopsis thaliana of the Proteasome Proteolytic Pathway: ACTIVATION IN RESPONSE TO CADMIUM.
... TOP, the MS characterization of LAP was investigated in the 80 –100-kDa protein fractions exhibiting LAP-like activity ...eluted from the Mono Q2 around 120 m M NaCl (Fig. 1C). The most ... Voir le document complet
15
Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry
... specific proteasome inhibitor [20,64- 67]. The crystal structure of the yeast proteasome in complex with epoxomicin revealed its unique mechanism of action due to its two adjacent ... Voir le document complet
60
[Critical role for p27 in mediating the antitumoral activity of a proteasome inhibitor]
... for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome ...with the cyclin-dependent kinase inhibitor ... Voir le document complet
5
Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease
... of the role of CYLD in CD as revealed by CD-associated bacteria The genetic results point towards the implication of CYLD in IBD ...colonise the gastrointestinal tract of IBD patients would ... Voir le document complet
11
Distinct alpha-Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH-SY5Y cells
... synucleinopathies, the degradation mechanism(s) involved could possibly represent a viable therapeutic ...suggests the involvement of the Proteasomal System in the degradation of soluble and ... Voir le document complet
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The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β
... evaluating the regulatory role of cytokines in proteasome expression and ...I. The shift in composition of proteasomes towards i-pro- teasomes, changes the peptide repertoire from ... Voir le document complet
22
Airway Mucus Restricts Neisseria meningitidis Away from Nasopharyngeal Epithelial Cells and Protects the Mucosa from Inflammation
... epithelial cells has been the subject of numerous studies over the past 4 ...However, the means by which meningo- cocci cross the nasopharyngeal wall is still under ...to the ... Voir le document complet
18
The Free Fatty Acid Receptor GPR40 Protects from Bone Loss through Inhibition of Osteoclast Differentiation
... enlightening the obligatory role of the GPR40 ...for the first time in translational approaches that GPR40 is a relevant target for the design of ... Voir le document complet
2
The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy
... The accumulation of Ub protein conjugates was assessed by im- munoblotting on myofibrillar protein extracts. Powder (150 mg) of gastrocnemius muscles was homogenized in an ice-cold buffer (buffer C) containing 5 ... Voir le document complet
12
The coordinated up-regulation of the ubiquitin-proteasome and autophagy-lysosomal pathways strongly alters the Human muscle proteome during ultra-endurance exercise
... Alice Decourt, Cécile Coudy-Gandilhon, Guillaume Millet, Cécile Polge, Lydie Combaret, Daniel Taillandier, Didier Attaix, Christophe Chambon, Léonard. Féasson, Daniel Bechet[r] ... Voir le document complet
5
Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway
... Ku70-Ku80-DNA-PKcs complex in cells Human topoI, a type 1B enzyme, can relax both negative and positive DNA super coiling by cutting and re- ligating the ...in the presence of CPTs, the ... Voir le document complet
20
COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.
... From the ‡ Institut de Biologie Environnementale et Biotechnologie, UMR 6191, CNRS-Commissariat a` l’Energie Atomique, Universite´ de la Me´diterrane´e Aix-Marseille II, Centre d’Etudes Nucle´aires ... Voir le document complet
13
Circulating 20S proteasome for assessing protein energy wasting syndrome in hemodialysis patients
... inflammation. The decrease in muscle mass is due to an imbalance in protein synthesis and proteolysis in favor of the latter [ 2 ...]. The ubiquitin- proteasome proteolytic system (UPS) is ... Voir le document complet
12
The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
... For the detection of CD3+, F4/80 + cells and C4d deposition, indirect immunoperoxidase staining was performed using the primary anti-CD3, anti-F4/80 antibody (1:50, AbD Serotec) or anti- C4d (1:50, ... Voir le document complet
51
Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1.
... of the M-T5 protein. Previous reports from our laboratory demonstrated that the MV M-T5 gene product is a virulence factor that is a critical determinant of cell tropism in both rabbit lymphocytes ... Voir le document complet
15
The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient β cells and is overexpressed in type 2 diabetes pancreatic islets
... β5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient β cells and is overexpressed in type 2 diabetes pancreatic islets Muhammad Saad Khilji, Sophie Emilie Bresson, Danielle ... Voir le document complet
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