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[PDF] Top 20 Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

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Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

... found in the brain, human brain tissue cannot be used to measure molecular biomarkers to monitor disease state and pro- gression in living ...ubiquitous expression ... Voir le document complet

14

Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders

Gene Expression Analysis Reveals Genes Common to Cerebral Malaria and Neurodegenerative Disorders

... increase and the encoded protein interacts with α-sy- nuclein, promoting its aggregation, which is ...expressed in the brain and promotes cell survival, particularly under conditions of ... Voir le document complet

7

Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

... Macaca expression microarray and choice of samples RNA from cerebral cortex (30 ng) and from blood sample (30 ng) were labelled using Low Input Quick Amp WT Labeling kit (Agilent ... Voir le document complet

16

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

... network analysis. A spectral decompo- sition of gene expression signals was performed against the probabilistic functional network MouseNet v2, which generates unbiased and precise predictions ... Voir le document complet

38

Single-cell gene profiling of human regulatory T cell subsets in human graft-versus-host disease

Single-cell gene profiling of human regulatory T cell subsets in human graft-versus-host disease

... the expression of CD45RA and HLADR, we have identified three different subsets of human FOXP3 + Treg in peripheral blood or cord blood, which present suppres- sive activity ... Voir le document complet

2

Chromosomal profiles of gene expression in Huntington's disease.

Chromosomal profiles of gene expression in Huntington's disease.

... RESULTS Analysis of blood samples The main pattern of chromosomal variation (40% of total variance) obtained from the dataset of blood samples clearly distinguished controls and HD ... Voir le document complet

11

Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington disease

Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington disease

... loss in patients with Huntington disease (HD) suggesting a lack of substrates for the Krebs ...used in clinical trials to promote energy production in patients with peripheral ... Voir le document complet

20

Cord blood transplantation in a child with Pearson's disease.

Cord blood transplantation in a child with Pearson's disease.

... 7 in PD have not yet been reported, except after a double myeloablative therapy with reinfusion of PBSC ...hematologic and non-hematologic ...tissue and mitochondrial ...feasible in PD ... Voir le document complet

1

Gene-environment interaction in Paget's disease of bone

Gene-environment interaction in Paget's disease of bone

... radicals and reactive oxygen species were widely discussed in previous studies ...increase in lipid peroxidation and a change in the composition of fatty ...transduction and ... Voir le document complet

122

Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer’s disease patients

Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer’s disease patients

... fied in neuronal cells of AD-D, AD-MCI and DS patients as well as in peripheral cells from individuals with ...here in PBMCs were signifi- cantly correlated in the AD diagnostic ... Voir le document complet

9

Disease and patient characteristics in NP-C patients: findings from an international disease registry.

Disease and patient characteristics in NP-C patients: findings from an international disease registry.

... data from previous studies [10,18,33], and highlights this major problem in ...patients and/or their family and pri- mary caregivers. In addition, it has been recommended that ... Voir le document complet

11

Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome

Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome

... samples from lung recipients, we performed microarray gene expression profiling of whole blood to identify early biomarkers of BOS, including samples from 49 patients with stable ... Voir le document complet

12

Whole genome Cardiac DNA methylation fingerprint and gene expression analysis provide new insights in the pathogenesis of Chronic Chagas disease Cardiomyopathy

Whole genome Cardiac DNA methylation fingerprint and gene expression analysis provide new insights in the pathogenesis of Chronic Chagas disease Cardiomyopathy

... failure and arrythmia are the main causes of ...development and progression are still not fully ...cruzi–reactive and heart-autoreactive T cells and macrophages, correlates with disease ... Voir le document complet

10

AN UNCOMMON FORM OF A COMMON DISEASE

AN UNCOMMON FORM OF A COMMON DISEASE

... located in the Indian Ocean, where he had been vaccinated with Bacillus Calmette-Guérin at ...tenderness and swelling of the left knee, slightly limited in range of ...lesion in the epiphysis ... Voir le document complet

3

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

... isolated from both genotypes were intact ( Fig. S6 A–C ). RNA isolated from the polysome gradients from WT mice showed the expected profiles: Htt exonic sequences, but not early intron 1 sequences ... Voir le document complet

6

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

... Results in a Small Polyadenylated mRNA. The HdhQ150 knock-in mouse model was generated by the insertion of ∼150 CAGs into exon 1 of the mouse Htt gene ...prepared from the brains of homozygous ... Voir le document complet

6

Correction: Disease and patient characteristics in NP-C patients: findings from an international disease registry

Correction: Disease and patient characteristics in NP-C patients: findings from an international disease registry

... References: 1. Patterson MC, Eugen M, Wijburg FA, Audrey M, Barbara S, Harir D, Vanier MT, Mercé P: Disease and patient characteristics in NP-C patients: findings from an international ... Voir le document complet

3

Data mining of gene expression changes in Alzheimer brain

Data mining of gene expression changes in Alzheimer brain

... samples and RNA extraction A total of 4 clinically diagnosed AD patients and 5 normal patients of similar age were used in this ...ranged from 4 − 8 ...timeframe and the RNA quality is ... Voir le document complet

32

Impaired blood rheology plays a role inthe chronic disorders associated with sickle cell- hemoglobin C disease: Blood viscosity in hemoglobin SC disease

Impaired blood rheology plays a role inthe chronic disorders associated with sickle cell- hemoglobin C disease: Blood viscosity in hemoglobin SC disease

... syndrome and painful vaso- occlusive crisis in children with sickle cell ...manifestations and risk of death in 415 patients with sickle cell anemia in the US and ... Voir le document complet

11

Income inequality, gene expression, and brain maturation during adolescence

Income inequality, gene expression, and brain maturation during adolescence

... the human cerebral cortex on MRI scans into gyral based regions of ...part in the Saguenay Youth Study and the following individuals for their contributions in designing the protocol, ... Voir le document complet

11

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