[PDF] Top 20 Claudin-low breast cancers: clinical, pathological, molecular and prognostic characterization
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Claudin-low breast cancers: clinical, pathological, molecular and prognostic characterization
... other molecular subtypes at several levels: clinicopathological, genomic, transcriptional, survival, and response to ...genes, and cancer stem cell –like features, and higher activity of ... Voir le document complet
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Inflammatory blood markers as prognostic and predictive factors for pathological complete response and toxicity in early breast cancer patients receiving neoadjuvant chemotherapy
... independent prognostic factor for relapse-free survival (Hazard Ratio [HR] = ...0.012) and shorter overall survival (HR = ...negative breast cancer molecular subtype, low white blood ... Voir le document complet
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A Tyrosine Kinase Expression Signature Predicts the Post-Operative Clinical Outcome in Triple Negative Breast Cancers
... Clinicopathological and Molecular Features To better characterize our classifier, we searched for correlations with the clinicopathological and molecular variables of tumors in the whole data ... Voir le document complet
20
Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution
... Claudin-low breast cancers are aggressive tumors de fined by the low expression of key components of cellular junctions, associated with mesenchymal and stemness ...primitive ... Voir le document complet
13
Low-Dose and Long-Term Olaparib Treatment Sensitizes MDA-MB-231 and SUM1315 Triple-Negative Breast Cancers Spheroids to Fractioned Radiotherapy
... 2D and 3D cell culture conditions highlighted the heterogeneous sensitivity between the two cell line ...function and known as a biomarker of PARPi sensitivity [ 36 – 39 ...migration and invasion ... Voir le document complet
19
Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers
... HER2 and that of MED1, STARD3 and GRB7, but not of TOP2A and the other genes localized on the distal side of ...STARD3 and GRB7 as described by Katoh et al. [37] and as recently ... Voir le document complet
13
Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer
... centrosome and along the microtubule lattice in interphase and decorates the mitotic spindle and spindle poles during mitosis ...mapping and functional analysis of the human centrosome-cilium ... Voir le document complet
16
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers
... (Supplementary Fig. 10a) followed by the erroneous fusion of the two loose ends of the sister chromatids during replication. This results in the formation of a bridged dicentric chromosome that is torn apart during the ... Voir le document complet
10
Proteinuria in COVID‑19: prevalence, characterization and prognostic role
... admission and D0, and our results must be interpreted ...included and non-included patients (Table S1) are observed, essentially in terms of mortality and time to ...system) and mixed ... Voir le document complet
12
Clinical and molecular classification of glioblastoma patients
... short and long survivors in each prognostic group, genetic factors influencing survival will be assessed within these prognostic ...ultimate clinical goal is to refine prognostic ... Voir le document complet
1
Congenital Microcoria: Clinical Features and Molecular Genetics
... chicks and during specification in the lens and retina but is switched of afterwards, ...deletions and therefore compromise the development of the iris and chamber ...canal, and ... Voir le document complet
14
The ventilatory efficiency and its clinical and prognostic value in cardiorespiratory disorders
... Affiliations: 1 Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France. 2 AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, sites Pitié- Salpêtrière, ... Voir le document complet
3
Prospective, multicenter French study evaluating the clinical impact of the Breast Cancer Intrinsic Subtype-Prosigna® Test in the management of early-stage breast cancers
... per–Pearson). Clinical and demographic characteristics were described by mean, median, standard deviation, range and ...analyzed and results com- pared (total scores and the component ... Voir le document complet
13
Age and WHO Performance Score are major clinical prognostic factors in glioblastoma
... Unit of Nervous System Disorders and Therapy, GIGA- Neurosciences, Liège.[r] ... Voir le document complet
6
Algorithm optimization for signature discovery: case of Breast Cancers
... • Prediction obtained on a model can assess it’s classification power: the “AUC”.. – High AUC value = Better prediction.[r] ... Voir le document complet
64
Statistical and algorithmic developments for the analysis of Triple Negative Breast Cancers
... CNAG and GIM, in terms of SNR, giving a more accurate localization of breakpoints validated by ...alternatively and iteratively both non-relevant and biologically relevant ...signal and vice ... Voir le document complet
277
Identification of 5 novel genes methylated in breast and other epithelial cancers.
... the low stringency approach. The low stringency candidate list was com- pared to a publically available expression array data for an experiment demonstrating the re-expression of genes in the MCF7 ... Voir le document complet
14
Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis
... ative and HER2+ ...advanced breast cancer have shown that early death is limited [ 32 , 33 ], and it is therefore unlikely that it has dramatically impacted the ...events and therefore might ... Voir le document complet
19
Oestrogen receptor negative breast cancers exhibit high cytokine content.
... demonstrating that IL-8 is regulated by HER2 in breast cancer cell lines [16]. In addition, IL-1β was inversely correlated to the age. IL-1β has been shown previously to be strongly expressed in high grade ... Voir le document complet
31
Prognostic Impact of Stromal Immune Infiltration before and after Neoadjuvant Chemotherapy (NAC) in Triple Negative Inflammatory Breast Cancers (TNIBC) Treated with Dose-Dense Dose-Intense NAC
... 29. Slamon, D.J.; Leyland-Jones, B.; Shak, S.; Fuchs, H.; Paton, V.; Bajamonde, A.; Fleming, T.; Eiermann, W.; Wolter, J.; Pegram, M.; et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic ... Voir le document complet
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