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[PDF] Top 20 Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes

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Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes

Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes

... donor-matched B cell and T cell We hypothesized that peripheral APC with unique proteomes generate different pools of APC-specific endogenous peptides for presentation via class II ... Voir le document complet

10

Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen

Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen

... developed and used a mouse model in which a Cre recombinase is expressed under the control of the Xcr1 gene while preserving XCR1 ...of MHC class II (MHCII) molecules on ... Voir le document complet

13

Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells

Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells

... in the blood of healthy donors, specifically a subset of CD4 + CD25 hi FoxP3 + natural regulatory T cells, and suggest that HLA-DR may have a functional role in these cells ...the class ... Voir le document complet

21

Antiviral CD8⁺ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

Antiviral CD8⁺ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

... INTRODUCTION Antigen-specific CD8 + T cells are a major defense against invading viruses, killing infected cells harboring non-self pro- ...step in this process involves T cell receptor (TCR) ... Voir le document complet

16

Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4 + T cells

Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4 + T cells

... processing and presentation of peptide antigen negative regulation of intracellular signal transduction positive regulation of cytokine production involved in immune response regulation of ... Voir le document complet

49

Exosome-driven transfer of tumor-associated Pioneer Translation Products (TA-PTPs) for the MHC class I cross-presentation pathway

Exosome-driven transfer of tumor-associated Pioneer Translation Products (TA-PTPs) for the MHC class I cross-presentation pathway

... cross- presentation of MHC class I-restricted peptides by professional antigen presenting cells (pAPCs), with the consequent detection and elimination of cells expressing the same ... Voir le document complet

17

CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells

CD40-stimulated B Lymphocytes Pulsed with Tumor Antigens Are Effective Antigen-presenting Cells That Can Generate Specific T Cells

... as antigen-presenting cells, the role of antigen-unspecific B lymphocytes in antigen presentation and T-lympho- cyte stimulation remains ...controversial. In ... Voir le document complet

8

T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells

T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells

... of human epithelial exosomes in antigen presentation, their capacity to load antigenic peptides, to bind immune target cells and to induce T cell activation was analyzed in ... Voir le document complet

33

MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.: MHC Class II tetramers

MHC Class II tetramers and the pursuit of antigen-specific T cells: define, deviate, delete.: MHC Class II tetramers

... production and proliferation (23). Similar results were obtained with a human HLA-DR2-peptide dimer: this construct induced proliferation in myelin basic protein (MBP)-specific T cell clones when ... Voir le document complet

32

Determination of class II peptide-MHC repertoires and recognition via large yeast-displayed libraries

Determination of class II peptide-MHC repertoires and recognition via large yeast-displayed libraries

... known MHC anchor residues P1, P4, P6, and P9 to maximize the number of correctly folded and displayed pMHC clones in the ...product and linearized pYAL vector backbone were mixed at a ... Voir le document complet

98

Studies of MHC class I antigen presentation & the origins of the immunopeptidome

Studies of MHC class I antigen presentation & the origins of the immunopeptidome

... cells in a single ...affinity and high specificity for their targets to measure protein ...changes in instrument parameters and experimental conditions, traditional FC results are limited to ... Voir le document complet

129

Central self-tolerance by thymic presentation of self-antigens and autoimmunity

Central self-tolerance by thymic presentation of self-antigens and autoimmunity

... against self-antigens expressed and presented by MHC proteins in the thymic ...of self-reactive T cells with their cognate self-antigens is thought to lead to their negative ... Voir le document complet

14

Mass Spectrometry Reveals Changes in MHC I Antigen Presentation After Lentivector Expression of a Gene Regulation System

Mass Spectrometry Reveals Changes in MHC I Antigen Presentation After Lentivector Expression of a Gene Regulation System

... expression in the vicinity of integration ...changes in the presentation of peptide antigens, including particular mechanisms involving the fusion proteins allowing rapamycin-inducible expression of ... Voir le document complet

9

Ecto-F1-ATPase and MHC Class I Close Association on cell membranes.

Ecto-F1-ATPase and MHC Class I Close Association on cell membranes.

... T lymphocytes expressing an antigen receptor (TCR) of the γδ type represent a small fraction (1-5%) of T cells in human blood and lymph nodes although they may be more abundant ... Voir le document complet

18

Carrier-induced, hapten-specific suppression: a problem of antigen presentation?

Carrier-induced, hapten-specific suppression: a problem of antigen presentation?

... treatment, and levels of specific Abs were measured in individual ...data in Figure 2 show that, as expected, the production of the TNP-specific IgG2a Abs elicited by TNP- KLH in alum was ... Voir le document complet

12

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage

... genome and its phage in the MG reference catalog and culturomics analyses of patients ...ATCC9790) and its phage in 3,027 adult and mother- infant metagenomes (mostly from ... Voir le document complet

113

Analysis of the non classical class I genes of the MHC in swine

Analysis of the non classical class I genes of the MHC in swine

... RNA and further referred to as SLA-7-1366 (accession number: ...1 and 2). The two exons matching to exon 4 were named exons 4a and 4b (Figure ...4a and 4b, the donor and acceptor splice ... Voir le document complet

223

Lymphocytes B régulateurs : état des connaissances

Lymphocytes B régulateurs : état des connaissances

... > Malgré l’existence d’un vaccin effi- cace, un tiers de la population mondiale a été en contact avec le virus de l’hépa- tite B (HBV) et plus de 240 millions de personnes sont infectées de façon chro- nique ... Voir le document complet

4

Discongruence of Mhc and cytochrome b phylogeographical patterns in Myodes glareolus (Rodentia: Cricetidae)

Discongruence of Mhc and cytochrome b phylogeographical patterns in Myodes glareolus (Rodentia: Cricetidae)

... individuals, and the percentage of variation distributed among the a priori defined phy- logroups was extremely ...groups and a very low level of among-group ...present in all of them (Table 1). ... Voir le document complet

19

Characterization of Antigen-Specific B Cells Using Nominal Antigen-Coated Flow-Beads

Characterization of Antigen-Specific B Cells Using Nominal Antigen-Coated Flow-Beads

... T and B-cell ELISPOT have also been used to measure committed B cell frequency against a given ...the antigen (which can for instance elicit an immune synapse for T cells or directly bind to ... Voir le document complet

11

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