[PDF] Top 20 Circulating PCSK9 levels are not associated with the conversion to type 2 diabetes

... In the larger cohort (ELSA-Brasil), baseline plasma PCSK9 concentrations were positively associated with FPG change at ...if the correlation is weak (an increase of about ...of ... Voir le document complet

... patients are at high risk of coronary heart disease, partly due to atherogenic dyslipidaemia ...dyslipidaemia are complex, and may involve the HIV-infected state and some antiretroviral ... Voir le document complet

... of the distribution for the variables was assessed using the Kolmogorov-Smirnov ...test. The chi-square test or the Fisher exact test was used to compare categorical ... Voir le document complet

... Along with the obesity epidemic, the diabetes epidemic has dramatically increased ...worldwide. The insulin-resistant state that is often associated with obesity ... Voir le document complet

... inhibitors are the two pharmaco- logic classes that have best proven to improve both surrogate and hard clinical endpoints in patients with ...appear to be at least partially ... Voir le document complet

... percentage. The effect of baseline serum RANKL on the progression of calcification of leg arteries between baseline and the end of the follow-up was ana- lyzed using univariable and ... Voir le document complet

... early. To achieve this goal, a multidisciplin- ary approach is ...interventions are needed in order to address a broader spectrum of out- comes such as patient-reported outcomes ...empowerment. ... Voir le document complet

... involving circulating factors, contribute to (and may even be the drivers of) altered insulin secretion in the living ...contributors are changes in FSH levels [ 44 , 45 ] in ... Voir le document complet

... compared to age-matched Wistar rats (Fig. 1A). Circulating glucose levels were similar in GK and Wistar rats at 2 weeks of age ...when the diet shifts from lipid-enriched maternal diet ... Voir le document complet

... Among the different BA species and ratios, total concentrations of 6 α- hydroxylated HCA negatively correlated with BMI, HOMA-IR and FLI, sug- gesting a role for 6 α-hydroxylation in the ... Voir le document complet

... exposure. The strong tracking of IgE over the life span evidenced by longitudinal studies suggests that it may be a useful indicator to focus on the investigation of long-term effects of ... Voir le document complet

... As the prevalence of type 2 diabetes and the risk of severe side-effects of oral antidiabetic agents are markedly increased with aging, special focus should be put on ... Voir le document complet

... and the continued identifi cation of increasingly more molecules involved in the insulin signaling cascade, the molecular mechanism (or mechanisms) that underlines the development of insulin ... Voir le document complet

... Type 2 diabetes is a progressive ...patients with ITDM are at a more advanced stage of their metabolic disorder, the need to switch to insulin reflects profound ... Voir le document complet

... hsa-miR-152-3p levels and patients’ characteristics (see Table 1). The lower association observed in the replication compared to the discovery step could also be due to ... Voir le document complet

... inhibitors are generally well-tolerated, and no increase in adverse events was noted compared to placebo or other comparatives, but again slight differences may exist between the different molecules ... Voir le document complet

... The results suggest that 11 patients with IGT would need to be treated for ...years to prevent one event of development of ...If the diagnosis of diabetes was based on 2 ... Voir le document complet

... able to a reduction in pro-in flammatory factors associated with com- bined therapy with ...thiazolidinediones are antidiabetic agents that have been shown to exert some anti-in ... Voir le document complet

... data are expressed as mean ± standard deviation (SD) or as median and interquartile when distribution was normal or non-normal respectively or as frequency for qualitative ...by the XLSTAT test for two ... Voir le document complet

... responses are less coordinated among hospitalized ...sought to identify the minimum set of features that could differentiate between hospitalized and nonhospitalized ...distinguished the ... Voir le document complet