[PDF] Top 20 Cellular models for the screening and development of anti-hepatitis C virus agents.
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Cellular models for the screening and development of anti-hepatitis C virus agents.
... is the high level of autofluorescence of primary human hepatocytes in culture which makes extremely difficult, if not impossible, to investigate intracellular events such as nuclear translocation ... Voir le document complet
50
Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma
... DAA-based anti-HCV therapies now enable more than 90% of SVR rate with all-oral regimens even in the cases hard to cure before ...risk of HCC development over a decade [48]. In ... Voir le document complet
14
Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic Concepts
... 3.3. Development of PRR Agonists for Combinational Therapeutic Approaches Currently, no PRR agonists have been approved for the treatment of a chronic ...adjuvant for ... Voir le document complet
21
Wildlife reservoir for Hepatitis E virus, Southwestern France
... rates of HEV RNA in the wild boar popu- lations of other European countries like the Netherlands ...(2.0%) and Germany (5.0%) are similar (2), and rates of HEV RNA are ... Voir le document complet
4
Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.
... analysis of HCVcc using a purification scheme involving an epitope tagged envelope protein displayed apoE on the virion surface ...[49]. The extent of this association is dependent on growth ... Voir le document complet
34
Hepatitis C virus infection and chronic kidney disease: Time for reappraisal
... prevalence of HCV infection ...risk of chronic kidney disease Studies are heterogeneous and ...regarding the risk of CKD development in HCV infected ...results of nine ... Voir le document complet
31
Hepatitis B virus genetic variability and evolution.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ... Voir le document complet
2
Host neutralizing responses and pathogenesis of hepatitis C virus infection.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ... Voir le document complet
2
Hepatitis C virus entry: molecular mechanisms and targets for antiviral therapy.
... epitopes of the E2 HVR-1 region (aa 384-410) (18, 25, 61), an epitope adjacent to the N-terminal region HVR-1 region (aa 408- 422) (26, 94), the E2 CD81 binding region (aa 474-494 and ... Voir le document complet
17
Screening of hepatitis E in patients presenting for acute neurological disorders
... Material and methods A registry was created in Grenoble Hospital University from 2014 to 2018 to prospectively collect data on patients with acute (<3 months) non-traumatic, non-metabolic, non-vascular neuro- ... Voir le document complet
5
Rheumatologic Manifestations of Hepatitis C Virus Infection
... C virus and sicca syndrome Sicca symptoms of either the mouth or eyes have been reported in 10-30% of HCV infected ...5% of patients with a defined Sjögren’s syndrome are HCV- ... Voir le document complet
16
Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient.: Mechanism of entecavir resistance
... year of entecavir therapy, HBV- DNA had decreased by three logs but viral breakthrough (more than 1-log increase) was observed two years ...later. The patient is currently being treated with lamivudine ... Voir le document complet
24
Selection of a suitable disc bioassay for the screening of anti-tumor molecules
... rod–shaped and virulent that is the causative agent of Crown Gall ...mass of tissue bulging from stems and roots of woody and herbaceous plants is ...produced. The ... Voir le document complet
8
CD81-receptor associations-impact for hepatitis C virus entry and antiviral therapies
... and translation of viral ...translation of HCV genome results in a ~3,010 amino acid polyprotein that is cleaved by host and viral proteases to yield 10 mature viral proteins consisting ... Voir le document complet
19
Hepatitis C virus-microelimination program and patient trajectories after hepatitis C virus cure in an outpatient HIV clinical unit
... The evaluation of patient trajectories after HCV cure showed a positive impact of recovering from HCV on various markers of physical and mental health as well as on health ...use ... Voir le document complet
35
Extrahepatic manifestations of chronic hepatitis C virus infection
... increase the risk of coronary artery disease, after adjustment for classical cardiovascular risk factors 75 .... Anti-HCV positive patients had higher mortality rates of cardiovascular ... Voir le document complet
19
Design and Development of Calcium Sensitive Contrast Agents for fMRI
... The second chapter, titled "Calcium- sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin", describes the work on o[r] ... Voir le document complet
138
Self-reported patient history to assess hepatitis B virus serological status during a large screening campaign
... stances and might complicate clinical follow-up while undergoing anti-hepatitis C virus or immunosuppressive therapies [ 40 ...limitations of our study need to be addressed. First, we ... Voir le document complet
9
DEVELOPMENT AND VALIDATION OF A NON-TARGETED SCREENING APPROACH FOR THE CHARACTERIZATION OF LUNG FLUIDS
... improvement of analytical instrumentation generates more and more insights for non- targeted ...context of untargeted screening of complex biological mixtures, comprehensive ... Voir le document complet
2
Hepatitis C virus-related vasculitis
... two-thirds of patients and mononeuritis multiplex in one-third of ...common and usually set in gradually. Vasculitis of the central nervous system (CNS) is rare but probably ... Voir le document complet
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