[PDF] Top 20 Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia.
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Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia.
... of cell adhesion on leukemia cell proliferation remain poorly documented and somehow ...controversial. In this work, we investigated the effect of adhesion to ... Voir le document complet
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NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia
... gene in human prostate cancer, in human T-ALL? To address this question, we first inhibited ...gene expression in the different TAL1 + /T-ALL cell lines studied and found a near ... Voir le document complet
17
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells -high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation
... CXXC5 expression; those genes with a known function according to the PubMed and Gene databases are listed in Supplementary Table ...proteins and their interacting ...including cell ... Voir le document complet
19
Aberrant Chloride Intracellular Channel 4 Expression Is Associated With Adverse Outcome in Cytogenetically Normal Acute Myeloid Leukemia
... p53- and c-myc-mediated apoptosis and transforming growth factor beta (TGF- β) signaling modulation in multiple cell types ( 10 ...involved in multiple cellular functions, including the ... Voir le document complet
14
Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients.
... overexpressed in leukemic cells of acute T-cell leukemia/lymphoma patients [13] and to be associated with chemotherapy cross-resistance and treatment outcome in childhood ... Voir le document complet
10
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy
... of acute myeloid leukemia (AML) to therapeutic agents is ...understood and addressed. In this paper, we demonstrate that inhibition of deubiquitinylase USP7 signi ficantly reduces ... Voir le document complet
17
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia
... metabolism in AML cells To characterize the transcriptional consequences of EVI1 overexpression in AML, we generated an EVI1-dependent gene signature from murine bone marrow Lin Low cells infected with a ... Voir le document complet
34
STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia
... STAT5 regulates CDC25A, either directly through gene transcription, or indirectly through post-transcriptional mechanisms that affect its mRNA level, or ...FLT3-ITD and STAT5 are involved in ... Voir le document complet
13
CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia
... investigated cell cycle regulation in acute myeloid leukemia cells expressing the FLT3-ITD mutated tyrosine kinase receptor, an underexplored field in this ...inhibition, ... Voir le document complet
19
en fr Targeting NPM1c in Acute Myeloid leukemia NPM1C, une cible dans le traitement des leucémies aigues myéloides
... ; and Hiba ...localized in the nucleolus. NPM1 is frequently mutated in acute myeloid leukemia ...(wt-NPM1), and this leads to its con-tinuous cytoplasmic delocalization ... Voir le document complet
241
Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia
... : In Acute Myeloid Leukemia (AML), a complete response to chemotherapy is usually obtained after conventional chemotherapy but overall patient survival is poor due to highly frequent ... Voir le document complet
19
Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients
... Acute myeloid leukemia (AML) intensive chemotherapy combined with broad-spectrum antibiotics, leads to gut microbiota dysbiosis promoting pathological conditions and an increased incidence of ... Voir le document complet
12
View of Specific pulmonary involvement in acute myeloid leukemia: from diagnosis to treatment
... Les leucémies aiguës myéloïdes (LAM) sont des hémopa- thies malignes agressives caractérisées par la croissance rapide des cellules leucémiques immatures (blastes) dans la moelle osseuse. Le diagnostic est posé sur un ... Voir le document complet
8
Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients
... components, and thus it is likely that the TCI has at least the same validity as the original RIC/MAC ...inherent in retrospective registry-based studies by studying a large patient cohort, by ... Voir le document complet
12
Acute inflammation down-regulates alpha-synuclein expression in enteric neurons
... level. In further experiments, it will be interesting to study if alpha-synuclein is up-regulated in a model of slowly progressive colitis that can be induced by administering 4–5 repeated cycles of ... Voir le document complet
16
Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia
... intensity and type of stimuli in distinct biologic models ...implicated in the proteaphagy activated by Bz in MOLM-14 ...receptors in this process [14]. For instance, both the ubiquitin ... Voir le document complet
24
Expression of p53 N-terminal isoforms in B-cell precursor acute lymphoblastic leukemia and its correlation with clinicopathological profiles
... least in relapse ...fold in pri- mary BCP-ALL and by about 11-fold in relapse ...higher in relapse than in primary ...efficiency and that the resulting p53 isoforms have ... Voir le document complet
10
New roles of STAT5 factors in chronic myeloid leukemia cell maintenance
... + and CD90 (Thy1) low , whereas human HSCs are hCD34 + , hCD38 - and hCD90 + ....(Iwasaki and Akashi 2007) The major representative and most used marker for human hematopoietic stem and ... Voir le document complet
166
Transplant Outcomes for Secondary Acute Myeloid Leukemia: Acute Leukemia Working Party of the European Society for Blood and Bone Marrow Transplantation Study.
... Secondary acute myeloid leukemia (sAML) has been associated with inferior outcomes compared with de novo ...factors and outcomes in sAML after allogeneic hematopoietic stem cell ... Voir le document complet
9
Late cardiomyopathy in childhood acute myeloid leukemia survivors: a study from the LEA program
... Impairment in several domains of QoL has been described in childhood cancer survivors, but to the best of our knowledge, our study is the first to focus on the impact of late cardiac ...difference in ... Voir le document complet
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