[PDF] Top 20 CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
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CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
... covalent CDK7 inhibitors for use against MYCN-amplified NB and other MYC-driven ...toxicity in a mouse model of ...global transcriptional amplifier (Lin et ...the transcriptional amplification ... Voir le document complet
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Anti-EGFR monoclonal antibodies and EGFR tyrosine kinase inhibitors as combination therapy for triple-negative breast cancer
... expressed in MDA-MB-468 cells, five genes involved in cell cycle progression (CCNA1, CCNB1, CCND1, CCNE1, CHEK1) were down-regulated by anti-EGFR ...genes in the MDA- MB-468 susceptible cell ... Voir le document complet
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en fr Fra-1 and Fra-2 in triple negative breast cancers : transcriptional mechanisms and identification of potential therapeutic targets Fra-1 et Fra-2 dans les cancers du sein triple négatifs : mécanismes transcriptionnels et identification de cibles thérapeutiques potentielles
... Il est maintenant établi que l’autophagie est impliquée dans de nombreuses pathologies dont le cancer. Le rôle de l’autophagie dans le cancer s’avère complexe et dépend probablement en grande partie du ... Voir le document complet
243
A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer
... France Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment ...expression in a large proportion of TNBC, thus qualifying as an ... Voir le document complet
14
EHD2 is a Predictive Biomarker of Chemotherapy Efficacy in Triple Negative Breast Carcinoma
... established in vitro cell migration/wounding assay to investigate the role of EHD2 in the aggres- siveness of Hs578T, MDA-MB-231 and MDA-MB-436 TNBC cells that are respectively defined as moderately ... Voir le document complet
13
Role of stable free radicals in conjugated antioxidant and cytotoxicity treatment of triple negative breast cancer
... Molecular targets for TNBC include BRCA1/2, PARP, cyclin-dependent kinases, CHK1 and WEE1, various growth factors (EGFR, HER2, VEGF, VEGFR2, VEGFR/FGFR) and angiogenesis, androgen receptor, PI3K/AKT/mTOR pathway, ... Voir le document complet
22
Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
... and cancer cell migration/invasion. In cancer, EMT involves complex cell signaling cascades that result in the alteration of cell –cell and cell–extracellular matrix interactions, leading to ... Voir le document complet
12
Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors
... for Cdk7 at different genes ( Glover-Cutter et ...THZ1 in human cells ( Kwiatkow- ski et ...factors—MYC in SCLC or neuroblastoma or RUNX1 in T-ALL ( Chipumuro et ...on addiction to a ... Voir le document complet
17
Targeting a cell state common to triple‐negative breast cancers
... mutations in cancer cells can be exploited for therapeutic ...many cancer subtypes, including triple- negative breast cancer (TNBC), no frequently recurring aberrations ... Voir le document complet
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A Bispecific Antibody-Based Approach for Targeting Mesothelin in Triple Negative Breast Cancer
... France Triple negative breast cancers (TNBC) remain a major medical challenge due to poor prognosis and limited treatment ...expression in a large proportion of TNBC, thus qualifying as an ... Voir le document complet
14
Increased macroH2A1.1 Expression Correlates with Poor Survival of Triple-Negative Breast Cancer Patients
... [33]. In E-cadherin negative cell lines this ratio was generally greater and more diverse, but the difference between E-cadherin positive and E-cadherin negative cells was not statistically ... Voir le document complet
13
Retinoic acid sensitivity of triple-negative breast cancer cells characterized by constitutive activation of the NOTCH1 pathway : the role of RARβ
... Introduction Triple-negative breast cancer (TNBC) accounts for 15–20% of all mammary tumors, and it is characterized by estrogen-receptor (ER), progesterone-receptor and HER2-receptor ... Voir le document complet
23
XENOBREAST Trial: A prospective study of xenografts establishment from surgical specimens of patients with triple negative or luminal b breast cancer
... summarized in Figure ...fixed in formalin and embedded in paraffin for histological studies; a third part is frozen in liquid nitrogen for molecular studies; and a last part is frozen ... Voir le document complet
11
Modeling Heterogeneity of Triple‐Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance
... levels in “subtype A” (A) and “subtype B” (B) MMTV-R26 Met tumors of the indicated proteins, considered as the hallmark of the “subtype A” cell lines (Table S5, Supporting ...(shown in (a)) were compared to ... Voir le document complet
18
In Vivo Assessment of VCAM-1 Expression by SPECT/CT Imaging in Mice Models of Human Triple Negative Breast Cancer
... frozen in −40 ◦ C isopentane, whereas metastatic lungs were inflated with a 1:1 mixture of PBS/Optimal Cutting Temperature prior being ...frozen. In order to investigate whether the VCAM-1 expression status ... Voir le document complet
14
Glycoproteomic comparison of clinical triple-negative and luminal breast tumors
... identified in this study as highly expressed in TN tumors are associated with degranulating neutrophils, suggesting a role for the innate immune response in TN breast cancer ... Voir le document complet
14
Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein abundance
... synthesis in eukaryotes, and, as many natural products, can be considered as a multi-target agent, although all its action targets are now ...48]. In TNBC, HHT-induced down- regulation of Myc protein may ... Voir le document complet
19
View of Triple Negative Breast Cancer: A review of common therapeutic Targets and Current Treatment options.
... of cancer, including prolifera- tion in the absence of growth signals, insensitivity to anti-growth factors, evasion of apoptosis, infinite replicative potential, inva- sion, metastasis, and sustained ... Voir le document complet
4
Predictive and prognostic role of peripheral blood eosinophil count in triple-negative and hormone receptor-negative/HER2-positive breast cancer patients undergoing neoadjuvant treatment
... into cancer tissue and induce normalization of the tumor vasculature ...survival. In the current study, the number of patients, the short follow-up time and the subsequent number of events registered are ... Voir le document complet
15
Protein arginine methyltransferase 5: A novel therapeutic target for triple-negative breast cancers
... twice in the top 25 compounds for which there is at least some additivity with EPZ015666 (Figure ...alone, in a subset of TNBC cell ...EPZ015666 in our initial cell viability assay (Figure 3A), and ... Voir le document complet
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