[PDF] Top 20 Towards a causative function of histone modifications in regulation of chromatin dynamics and transcription

... H3K122, a residue at the lateral surface, as a novel acetylation site and use it as a model to study the mechanism of action of lateral surface ...applying a genome-wide ... Voir le document complet

... repair in the chromatin context DNA is organized into nucleosome core particles, where 147 bp of DNA wraps in ...around a histone octamer. The histone octamer is composed ... Voir le document complet

... (2002) Histone lysine methylation: a signature for chromatin ...DNA and histone methylation in MULE-F19G14/CyP40 and other representative ...Similarity in the DNA ... Voir le document complet

... Post-translational modifications (PTMs) of histones have emerged as key players in the regulation of gene ...discovery of histone acetylation, there has been a ... Voir le document complet

... example of a 5 ’/3’ gene loop has been thoroughly described in Arabidopsis at the FLC ...’ and the 3’ part of the FLC locus [ 12 ...loop dynamics through the modulation of ... Voir le document complet

... 2 of 32 1. Introduction Morphogenesis in plants relies on continuous and iterative production of new organs with specific ...functions. In annual plants like Arabidopsis thaliana, upon ... Voir le document complet

... H3 dynamics during DNA replication DNA replication is a critical moment during the cell cycle that challenges epigenetic inheritance, but also presents a window of opportunity to initiate ... Voir le document complet

... The regulation of chromatin dynamics is a key mechanism that controls essential cellular functions such as gene expression, DNA repair, and replication (Voss and Hager, ... Voir le document complet

... complexity of carcinogenesis cannot be represented by genetic mutations alone, but also involves profound epigenetic ...epigenetic regulation of the genome includes among others, histone post- ... Voir le document complet

... out in two batches, the first for H3K4me3, H3K9ac, and H3K27ac, the second for H3K4me2, H3K14ac, H3K36me3, H4K20me3, H3K79me2 and ...the histone PTM and gene expression data were fully ... Voir le document complet

... expressed in both systems consistent with previous reports (Mavrakis et ...ease of use, E. coli was selected for the production of protein for crystallization experiments (Table ...only of ... Voir le document complet

... males of genotype y w; UAS-Gal4/CyO; Bam-Gal4, ...efficiency of depletion of these three proteins, judged by immunofluorescence, was insufficient at ...Testes of young males (less than 24 h ... Voir le document complet

... technique, in addition to low-mass ions, allows ionization of intact proteins larger than 100 kDa ...used in mass fingerprinting analysis of peptides, nucleic acids and ...generation ... Voir le document complet

... frequency of interaction between specific subgenomes: A and B interact more frequently than do A and D or B and D ...history of modern wheat: the hybridization event at ... Voir le document complet

... showed that methylation downstream from the transcription start site, can affect gene 33. expression in plant protoplasts, but the effect upon transcript elongation was not investigated.[r] ... Voir le document complet

... Il a été suggéré que la diminution du contenu en amidon dans le mutant sh1 était en fait le résultat d’une dégénération cellulaire causée par l’incapacité des cellules mutantes de synthétiser la cellulose qui est ... Voir le document complet

... pathologies In increasing numbers of cancer types mutations in the cohesin complex or its regulators are ...mutations in the cohesin complex subunits STAG2, RAD21, SMC1 and SMC3 were  ... Voir le document complet

... premature transcription termination by obscuring transcription termination ...ends of genes in Arabidopsis, suggesting that methyla- tion is deleterious for transcription termination ... Voir le document complet

... grown in standard medium, treated or not with ...3a) and dead cells (trypan blue, ...h and 48 h following HDACi addition. Reduced cell growth in TSA treated cells was partly rescued in ... Voir le document complet

... gift of trastuzumab (Herceptin), and Drs ...Imaging and Sequencing platforms. The Receptor Signalling and Molecular Scaffolds laboratory at the Institut Cochin is part of the ... Voir le document complet