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[PDF] Top 20 The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

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The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

... as sensors for the mTORC1 pathway reveal that GATOR2 is a critical hub of amino acid sensing, where leucine and arginine signals converge upstream of the Rag GTPases to ... Voir le document complet

23

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

... the idea that they are activating mTORC1 via other mechanisms such as Rag-dependent mTOR local- ization ( Figure 1D ...control mTORC1 activity; however, it remains controversial whether it is ... Voir le document complet

24

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

... of the amino acid sensors across evolution Study of the nutrient sensing pathway revealed that some of its components were conserved in many eukaryotes (Figure ...of mTORC1, such as TOR ... Voir le document complet

20

Biomimetic diamond MEMS sensors based on odorant-binding proteins: Sensors validation through an autonomous electronic system

Biomimetic diamond MEMS sensors based on odorant-binding proteins: Sensors validation through an autonomous electronic system

... on the grafting of porcine OBP onto diamond micro-cantilevers using a different chemical approach enabling the use of integrated components and offering the possibility to use a dedicated electronic ... Voir le document complet

4

The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway

The LKB1 complex-AMPK pathway: the tree that hides the forest.: The LKB1 complex-AMPK pathway

... interaction are considered as autophosphorylation sites revealing LKB1 complex activity [42 ] ...In the same conditions, STRAD phosphorylation sites α have also been identified, though these sites ... Voir le document complet

10

Varicella-Zoster Virus IE4 Protein Interacts with SR Proteins and Exports mRNAs through the TAP/NXF1 Pathway.

Varicella-Zoster Virus IE4 Protein Interacts with SR Proteins and Exports mRNAs through the TAP/NXF1 Pathway.

... proteins are shuttling proteins suggests that IE4 targets their export adaptor function rather than their splicing factor ...activity. The highly conserved SR protein kinase 1, SRPK1 [23], was ... Voir le document complet

13

Targeting the AMPK pathway for the treatment of Type 2 diabetes.

Targeting the AMPK pathway for the treatment of Type 2 diabetes.

... Benoît Viollet, Louise Lantier, Jocelyne Devin-Leclerc, Sophie Hébrard, Chloé Amouyal, et al... Tar- geting the AMPK pathway for the treatment of Type 2 diabetes...[r] ... Voir le document complet

3

Role of the Arginine 214 in the substrate specificity of OXA-48

Role of the Arginine 214 in the substrate specificity of OXA-48

... efficiencies (kcat/Km) of these two mutants were in agreement with the MIC values.. and OXA-48) and a loss of temocillin hydrolysis. The glutamate substitution seems to have a 248[r] ... Voir le document complet

29

Formation of convective cells in the scrape-off layer of the CASTOR tokamak

Formation of convective cells in the scrape-off layer of the CASTOR tokamak

... of the particle and heat transport at the tokamak edge is of primary importance for design of future large-scale ...requirements for the transport properties of the plasma inside ... Voir le document complet

8

Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis

Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis

... Bcl-2 proteins (Fig. 3A and fig. S3A). We further analyzed the antiapoptotic activity of trBcl-2L1 and trBcl-2L2 proteins using HeLa cells treated with three apoptosis-inducing agents: thapsigargin, ... Voir le document complet

15

Gene regulation in response to graded hypoxia: The non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway

Gene regulation in response to graded hypoxia: The non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway

... space The formula for HIF TOT (Equation [3]) allows us to understand what are the parameters which control HIF TOT in an oxygen gradient, namely [HIF] 0 , a 1 , d 1 , b 1 , [PHD] 0 , l 0 and τ ... Voir le document complet

26

Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans

Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans

... ment. For example, in the anterior pharynx, postdeirid and ventral cord, cells that are fated to die survive only 0–7 % of the time in a ced-1 engulfment mutant [12], making ...of the ... Voir le document complet

15

Applying the electronic nose in the environment : requirements for the sensors

Applying the electronic nose in the environment : requirements for the sensors

... sufficient for many applications. We see that some observations belong to the “no man’s land” between the groups : that is normal, those are either observations made around the odorous ... Voir le document complet

23

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

... that the sole activation of the PERK-ATF4 axis is sufficient to increased GFAT1 ...that the effect of ATF4 likely occurs at the transcriptional level ...in the basal transcription level ... Voir le document complet

10

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

... that the sole activation of the PERK-ATF4 axis is sufficient to increased GFAT1 ...that the effect of ATF4 likely occurs at the transcriptional level ...in the basal transcription level ... Voir le document complet

11

What are the Judicial Options for the future EU/UK agreement?

What are the Judicial Options for the future EU/UK agreement?

... In the first case, the UK would be present in the EFTA Surveillance Authority, the EFTAC and the EEA ...negotiate for the UK government, even if it is said that the ... Voir le document complet

30

Use of castor oil for aroma production by the yeast Yarrowia lipolytica: optimization of operating conditions

Use of castor oil for aroma production by the yeast Yarrowia lipolytica: optimization of operating conditions

... 2 Center for Biochemical Engineering, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark 3 Institute of Engineering in Life Sciences, Department III: Bioprocess Engineering; Building 30.70, Straße am ... Voir le document complet

1

Stress-induced enhancement of colitis in rats: CRF and arginine vasopressin are not involved

Stress-induced enhancement of colitis in rats: CRF and arginine vasopressin are not involved

... animals, cicatricial tissue was observed, whereas seven of eight rats presented ulcerations exceeding the submu- cosa, severe edema and mucosal atrophy, inflammatory [r] ... Voir le document complet

9

Arginine behaviour after arginine or citrulline administration in older subjects

Arginine behaviour after arginine or citrulline administration in older subjects

... supplements Arginine (ARG) is known to be a versatile amino acid (AA), and its metabolic properties have been extensively studied (1) .... The metabolic pathways of ARG and CIT are closely ... Voir le document complet

6

The design of polymeric microneedles for the delivery of sensors for real-time physiological monitoring

The design of polymeric microneedles for the delivery of sensors for real-time physiological monitoring

... Around the same time, Zimmerman and Stoeber proposed a similar device for withdrawing ISF using hollow silicon MN ...without the need to draw blood. Notably, they proposed the incorporation of ... Voir le document complet

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