[PDF] Top 20 Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension
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Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension
... doi:10.1152/ajpheart.01084.2011.—Pulmonary hypertension provokes right heart failure and ...the mechanisms underlying these arrhythmias is needed to facilitate new therapeutic ... Voir le document complet
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Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline.
... of pulmonary hypertension: the task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), ... Voir le document complet
12
BET Bromodomain Inhibitors and Pulmonary Arterial Hypertension: Take Care of the Heart
... arterial hypertension (PAH; group 1 pulmonary hypertension [PH]) is a progressive pulmonary vascular disease with a poor prognosis that culminates in right heart ... Voir le document complet
3
Cardiac overexpression of PDE4B blunts β-adrenergic response and maladaptive remodeling in heart failure
... DISCUSSION In the present study, we tested whether the cAMP-specific PDE4B is decreased in human HF as reported previously in pressure overload-induced hypertrophy in ...mice ... Voir le document complet
79
Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.
... improves cardiac function and remodeling without changing blood pressure At 3 weeks, HS rat hearts had increased wall thickness (Table S2) and calculated ventricular mass compared with LS hearts (Figure 2B) ... Voir le document complet
13
Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats
... mechanism by which MCT-induced PH is complex[ 21 ], and to investigate the direct role of p53 in the pathogenesis of PH, we chose to investigate the consequence of the inhibition of p53 activity ... Voir le document complet
13
Determinants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.
... increase in sPAP in SSc may result from both pre- and post-capillary involvement as demonstrated by the multiple linear regression ...exercise-induced pulmonary hypertension and ... Voir le document complet
7
Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure
... tion in early studies was probably ...irrelevant in RV ...error in the disadvantage of the failing RV. In other words, even if the methods of assessment are imperfect, does not the con- ... Voir le document complet
16
Transcatheter Mitral-Valve Repair in Patients with Heart Failure.
... incorrect in stating that enrollment in the COAPT trial was “supervised” by the ...confirmed by a physician- led, sponsor-independent, central eligibility com- mittee and echocardiographic ... Voir le document complet
4
Tumour biomarkers: association with heart failure outcomes.
... medians with interquartile ranges (IQR), when data were non-normally ...tested with an extension of the Wilcoxon rank-sum ...variables, in which all variables associated with tumour biomarkers ... Voir le document complet
13
en fr Cardiac gene therapy with phosphodiesterase PDE4B in a mouse model of heart failure Surexpression cardiac de PDE4B1 à l'aide d'un virus adéno-associé
... measurements by fluorescent resonance energy transfer (FRET) ...infected with adenoviruses to measure cAMP and PKA activity, ...experiment by checking their ...maintained in the Ringer ... Voir le document complet
47
Role of Sirtuin-1 in the pathogenesis of hypertension in spontaneously hypertensive rats : molecular mechanisms
... determined by Western blotting using specific antibodies as described previously 7, 8 ...membrane with a semi–dry transfer blot apparatus (Bio-Rad Laboratories) at 15 V for 45 ...twice in PBS and ... Voir le document complet
119
Biochemical mechanisms involved in pulmonary hypo-alveolarization induced by peroxides contaminating parenteral nutrition in newborn guinea pig
... The failure to obtain a rescue with DTT in tissues from PN group suggests that the inhibition is caused by a different way than oxidation of thiols by ...glutathione in PN to ... Voir le document complet
215
Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure.: Local energy regulation is impaired in HF rats
... Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure.: Local energy regulation is impaired in HF rats.. HAL is a multi-discipli[r] ... Voir le document complet
29
Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome
... (green) in the centre of the ...Trp81 with Cys68 (white) and Cys111 (magenta). In additional rotamers, the bulky tryptophan sidechain will severely bump into Leu67 (grey), Val87 (pink), Val108 (cyan) ... Voir le document complet
18
Neutralization of CXCL12 attenuates established pulmonary hypertension in rats Short Title: CXCL12 neutraligands in severe PH in the rat
... help with the animals. This research was supported by grants from the French National Institute for Health and Medical Research (INSERM), the Centre National de la Recherche Scientifique (CNRS), the ... Voir le document complet
29
Heart Failure with preserved Ejection Fraction: Defining phenotypes
... Heart failure with preserved ejection (HFpEF) has been increasingly recognized as an epidemic and various phenotypes have now been suggested ...vary in this ...decrease in quality of ... Voir le document complet
8
Baroreflex Activation Therapy in Patients With Heart Failure With Reduced Ejection Fraction.
... change in cardiovascu- lar structure or function ...reduction in the NT-proBNP data of 25% made it highly probable that morbidity and mortality would also be reduced, and that structural and functional ... Voir le document complet
14
A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents.: p130Cas Over-Expression in Pulmonary Hypertension
... role in the transduction of the RTK signaling ...state in control and iPAH PA-SMCs in both basal conditions and following exposure to exogenous EGF, FGF2, and PDGF in presence or in ... Voir le document complet
38
Oxidative Stress and Obesity- and Type 2 Diabetes-Induced Heart Failure
... and cardiac dysfunction in the context of diabetes ...the heart during T2D. In their study, Kar et ...change in the antioxidant hydrogen sulfide in the heart and a ... Voir le document complet
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