[PDF] Top 20 Canagliflozin: A Review in Type 2 Diabetes.

... Abstract Canagliflozin (Invokana ® ) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 ... Voir le document complet

... Troglitazone in the Prevention of Diabetes (TRIPOD) study (4), conducted in Hispanic-American women, that lowering endogenous insulin requirements can slow or stop the loss of β-cell function, which ... Voir le document complet

... with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research ...mortality in type 2 diabetes: a cohort ... Voir le document complet

... CONCLUSION In summary, our study shows that a high SAF predicts ...ment in subjects with type 2 ...AGEs in tissues, and glucose memory, in the increased risk of cancer ... Voir le document complet

... available. a 53 ...insulin in type 2 diabetes mellitus Insulin therapy in T2DM patients is frequently initiated while oral glucose-lowering agents (most often metformin, ... Voir le document complet

... improvements in skeletal muscle mitochondrial function have already been studied in healthy subjects [28] and in insulin resistant patients, including type 2 diabetes mellitus ... Voir le document complet

... Commentary (799 words starting from context including references) Context Metformin is considered as the best initial pharmacological option to lower glucose concentrations in patients with type 2 ... Voir le document complet

... for type 2 diabetes mellitus, the mechanisms underlying the plasma glucose level‐lowering effects of metformin (1,1‐ dimethylbiguanide) still remain incompletely ...changes in hepatic insulin ... Voir le document complet

... concentrations in both non-diabetic and diabetic overweight/obese patients. In addition, a ...reduction in HbA1c levels was observed in metformin- or sulphonylurea-treated patients with ... Voir le document complet

... plays a key role in the pathophysiology of type 2 diabetes (T2DM), and weight loss is a major objective, although difficult to achieve with medical ...efficacy in ... Voir le document complet

... 81] In a meta-analysis of RCTs, no signal of increased risk for DKA was observed for SGLT2is as a class (MH-OR, ...However, a large claims database of commercially insured patients in ... Voir le document complet

... performed in all cases; the author of this study was contacted to confirm the proportion of these cases, but by the time of submission of this paper no answer was ...T1D: Type 1 Diabetes. ... Voir le document complet

... measured in part by the number of people tested with a HbA 1c could be overes- timated by the fact that the HbA 1c values for prediabetes or diabetes screening had not been identified before 2010 and ... Voir le document complet

... to a plasma membrane receptor, dating back from the early ‘70s, suggested that the altered sensitivity to insulin as observed in obesity, insulin resistance and type 2 diabetes could be ... Voir le document complet

... induces type 2 diabetes at adulthood in male mice Hanna Ilchmann, Maiwenn Olier, Corinne Lencina, Sandrine Ellero-Simatos, Michèle Nankap, Ambre Riba, Caroline Sommer, Hervé Guillou, Laurence ... Voir le document complet

... being a primary objective in the management of type 2 diabetes, optimal glycaemic control is difficult to achieve and usually not maintained over ...time. Type 2 ... Voir le document complet

... the diabetes epidemic has dramatically increased ...of type 2 diabetes ...dysfunctions. In 1993, Hotamisligil et ...increased in the blood and in the adipose tissue (AT) ... Voir le document complet

... manage type 2 diabetes after failure with ...decline in β-cell function that is responsible for loss of glucose control, and the development and progression of chronic diabetic ...question. ... Voir le document complet

... demonstrate a beneficial effect of adding a new drug, ...medication. In their provocative analysis suggesting that aspirin prevents 32% of ischaemic heart disease events when used alone but prevents ... Voir le document complet

... II) in T2DM patients is more robust than for ACE ...equivalent in terms of patient characteristics and sample size for ACE inhibitors) are available with ARA II in T2DM patients: IDNT [ 37 ] and ... Voir le document complet