[PDF] Top 20 Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort.

... because the overall health risks exceeded the benefits. In particular, it showed an increased breast cancer risk in the CEE plus MPA ...recently, the Million ... Voir le document complet

... history of breast cancer in first-degree relatives (yes/no), age at menarche (cut points: 12, 13, and 14), age at first full-term pregnancy (cut points: 23, 26, and 30 years), parity (0, 1-3, ... Voir le document complet

... two types of physical activity. The decrease in risk observed with a
12 MET-h/week exercise level is consistent with the World Cancer Research Fund recommendations ... Voir le document complet

... -positive breast cancer with the menopause-related ces- sation of ovarian estrogen and/or progesterone synthesis ...array of epidemiologic, clinical and experimental evidence has ... Voir le document complet

... analyses to women who had not been using HRT before the baseline questionnaire (‘‘incident ...analysis in this way in our previous study [16], to avoid potential biases described by Ray ... Voir le document complet

... now in their late 50s and early 60s were at the start of their contraceptive life when OCs became readily available in the ...had the possibility of using OCs at a young ... Voir le document complet

... important to realize that recent findings relating to the use of natural progesterone, in sharp contrast with those referring to the use of progestins, are ...two ... Voir le document complet

... Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) is a multi-center prospective cohort study designed to investigate the relationships between diet, ... Voir le document complet

... strength of our study lies on the regular updates of exposure, which limited classification bias and allowed to account for possible changes over time in the types ... Voir le document complet

... is the first to consider different types of MHT combinations on diabetes risk, several authors have reported the impact of different types of ... Voir le document complet

... Meta-analysis of observational studies showed that oral but not transdermal oestrogen increased the risk of venous ...interval) of first-time venous thromboembolism in current ... Voir le document complet

... lower risk of ER-/PR- breast cancer in women with serum levels of PCBs in the highest tertile compared to the lowest ...investigating breast ... Voir le document complet

... underlies the method of weighting used in our analyses is that the absolute disease risks are well estimated and ascertainment is not dependent on the covariates of interest ... Voir le document complet

... polymorphisms in the genes that code for GNRH1 or its receptor and either cir- culating ovarian sex hormones or breast cancer ...influence of SNPs in these two genes on ... Voir le document complet

... that breast cancer risk decreases with increasing age at menarche ...that in our study the role of age at menarche was apparent only before adjustment for age at onset of ... Voir le document complet

... microarray. The unprecedented ability to monitor the expression of entire genomes has led to biological discoveries that would not have been possible by other ...inability to ... Voir le document complet

... All the current reports indicate that chronologic aging, climacteric estrogen deficiency, and adequate hormone therapy exert profound effects on various parts of the skin... Introduction[r] ... Voir le document complet

... for breast cancer and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models with age as the ...risks of breast cancer associated with ... Voir le document complet

... for the following baseline characteristics: age (continuous), BMI (continuous), smoking status (current, former, and nonsmokers), height (continuous), alcohol intake (continuous), physical activity (low, moderate, ... Voir le document complet

... as the time scale and adjusted for years of education (≤12, 13-16, ≥15), height (as continuous variable), body mass index category (as a time- dependent variable according to the height at ... Voir le document complet