[PDF] Top 20 Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
Has 10000 "Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents" found on our website. Below are the top 20 most common "Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents".
Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents
... Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating ...of in vitro barrier properties and ... Voir le document complet
15
Transient and Local Increase in the Permeability of the Blood-Brain Barrier and the Blood-Retinal Barrier by Hyperthermia of Magnetic Nanoparticles in a Rat Model
... offers an increase in CNS barrier permeability through a mechanism that widens the tight junctions [33], ...proposed. In this technique MNPs release a thermal energy when exposed to an ... Voir le document complet
127
Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics
... design: Brain endothelial cells, pericytes and astrocytes are cultured together in low-adherence condition in a 1:1:1 ratio, and allowed to self-assemble into multicellular spheroids over a ... Voir le document complet
32
Blood-brain barrier model on a microfluidic chip for the study of tumor cell extravasation
... To integrate these features into a physiologically relevant blood-brain barrier model, we designed an in vitro microvascular network platform formed via vasculogenesis[r] ... Voir le document complet
58
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation.
... addressed in the next future, in particular taking advantage of new and/or global analysis ...technologies. For example, super- resolution light microscopy (time-lapse stimulated emis- sion depletion ... Voir le document complet
13
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.
... crucial for this ...to an abundant source of differentiated BBB cells, to perform drug screening for ...cells in basic research or drug development [37,38]. The model proposed in ... Voir le document complet
13
Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease
... Microfluidic Platform: The micropatterned master with features 150 µm in height was fabricated by using standard ...cured in an oven at 80 °C for ...outlets for media and ... Voir le document complet
11
Setting-up an in vitro model of rat blood-brain barrier (BBB): a focus on BBB impermeability and receptor-mediated transport
... characterize an optimized and highly reproducible rat syngeneic BBB model using co-cultures of primary brain endothelial cells and ...rats for brain endothelial cell production and astrocyte ... Voir le document complet
18
Brain Inflammation, Blood Brain Barrier dysfunction and Neuronal Synaptophysin Decrease after Inhalation Exposure to Titanium Dioxide Nano-aerosol in Aging Rats
... analysis. For brain content Ti analysis, statistical analysis was performed using Stata 14 (StataCorp ...IP10 for both aged groups; RANTES for aging group) or Kruskal-Wallis test followed by ... Voir le document complet
14
From Blood to Lesioned Brain: An In Vitro Study on Migration Mechanisms of Human Nasal Olfactory Stem Cells
... (RT-qPCR) in control ( n = 5) and lesioned ( n = 6) ...https://doi.org/10.1155/2017/1478606 for assay IDs). For each experiment, 25 ng of previously prepared hip- pocampus cDNA were ...run in ... Voir le document complet
19
Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents
... the blood-brain barrier (BBB) locally, transiently, and without damages, allowing the delivery to brain tissues of large molecules which can- not normally access the central nervous system ... Voir le document complet
12
Advances in targeted chemotherapy using MRI-guided focused ultrasound to disrupt the blood-brain barrier
... In the previous chapter on drug quantification, we demonstrated that it is possible to achieve therapeutic levels of doxorubicin in localized areas of the brain by using [r] ... Voir le document complet
121
Collagen scaffolds for treatment of penetrating brain injury in a rat model
... oligodendrocytes... Implanted neural progenitor differentiated into a perineuronal satellite oligodendrocyte. a) DAPI staining (magenta) showing nuclei of all cells in the fie[r] ... Voir le document complet
204
Study of the antiepileptic drugs transport through the immature blood-brain barrier
... selected in order to evaluate if age related differences of cells that are used for the construction of these models were taken in ...controlled. In some models where EC age is stated it is ... Voir le document complet
198
In vivo imaging of blood-brain barrier disruption in a multiple sclerosis animal model
... is an imaging technique that provides good lateral resolution and sec- tioning of the plane of ...As in widefield microscopy, one-photon excitation generates the ...focused in one point at the ... Voir le document complet
97
Molecular mechanism of ultrasound interaction with a blood brain barrier model
... that blood vessels were not altered morphologically by ...showed, for the first time, that it may be possible to select ultrasound parameters that allow for a BBB disruption without risk of produc- ... Voir le document complet
22
Emerging technologies for delivery of biotherapeutics and gene therapy across the blood–brain barrier
... to brain endothelial cells and are capable of triggering receptor medi- ated ...biodistribution in rats [ 69 ]. Others [ 70 – 72 ] have utilized in vivo phage-display bio-panning to identify peptides ... Voir le document complet
14
Blood–brain barrier models in pre-clinical assessment of CNS-targeting cell and gene therapies
... ences in immune systems, receptor expression and antibody cross-reac- ...tivity. For CNS-targeted therapies, human BBB models that recapitu- late essential molecular and physio- logical features of the BBB ... Voir le document complet
12
Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL
... that blood brain barrier (BBB) leakage, possibly mediated by pericyte deficiency, plays a pivotal role in the formation of ...loss in CADASIL WMLs. Using post-mortem brain tissue ... Voir le document complet
15
Chronic depletion of gonadal testosterone leads to blood–brain barrier dysfunction and inflammation in male mice
... here, for the first time, that testosterone modulates levels of claudin-5 and ZO-1 proteins in male mice ...BBB. In agreement with these observations, a recent in vitro study reported ... Voir le document complet
35
Sujets connexes