[PDF] Top 20 CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates
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CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates
... sepsis in 2 animals, loss of donor chimerism in 1 animal, and secondary graft loss in 1 ...occurred in the setting of intact reconstitution of CD4 cells compared with autologous ... Voir le document complet
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Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model
... inTrODUcTiOn Graft-vs-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), used to treat hematological ...necessary to eliminate residual ... Voir le document complet
11
CD28 Blockade Ex Vivo Induces Alloantigen-Specific Immune Tolerance but Preserves T-Cell Pathogen Reactivity
... contribute to reconstitution of protective immunity after allogeneic hematopoietic stem cell transplantation (HSCT) but must acquire specific tolerance against recipient alloantigens to avoid ... Voir le document complet
16
Preclinical Testing of Antihuman CD28 Fab′ Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease
... compared to controls (Figure 5E). FR104's effect on peripheral T cell numbers was durable, and very few NHP T-cells were found at the end of the experiment (day 100), 76 days after the last dose of ... Voir le document complet
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Targeting the Human T-Cell Inducible COStimulator Molecule with a Monoclonal Antibody Prevents Graft-vs-Host Disease and Preserves Graft vs Leukemia in a Xenograft Murine Model
... inTrODUcTiOn Graft-vs-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), used to treat hematological ...necessary to eliminate residual ... Voir le document complet
11
Combination of Regulatory T Cells Injection with Rapamycin for Treatment of Chronic Graft-versus-Host Disease
... Upon activation, specific killing of T2 cells loaded with agonist peptide, was ...observed. In vitro generated T-cells showed clearly higher percentages of tetramer- positive cells compared with ... Voir le document complet
1
IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates
... France) in the upper region of the leg, 4 and 2 weeks before the DTH skin ...USA) in the skin on the right back of the ...3 to 12, and was considered positive when above 4 mm in ...point. ... Voir le document complet
14
Rapamycin Delays Xenogeneic Acute Graft Versus Host Disease (aGVHD) in Nod/Scid/Il2RγNull (NSG) Mice: Impact of Regulatory T Cells
... elevation in the thymic compartment of recipients that received S-59 treated T cells ...(mean-28.44pg/ml versus 1.45pg/ml, p 5 0.0059). In-vivo track- ing of S-59 treated T cells demonstrated the ... Voir le document complet
1
Photochemotherapy Induces a Faster Apoptosis of Alloreactive Activated T Cells Than of Nonalloreactive Resting T Cells in Graft Versus Host Disease
... 26). In vitro, monocytes can easily be turned into DC by 6-day culture in the presence of GM-CSF and ...IL-4. In these conditions, we have shown here that PUVA-treated monocytes differentiated into ... Voir le document complet
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In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation
... tail-less CD28 knock-in mice Tail-less CD28 knock-in (KI) mice (CD28 N163* also termed CD28 KI) were generated in the laboratory (Figure ...mutagenesis in the exon ... Voir le document complet
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Combination of Regulatory T Cells Injection with Rapamycin for Treatment of Chronic Graft-versus-Host Disease
... transduced to express the TCRa and TCR chains of HLA-A2 restricted TCRs recognising epitopes of cytomegalovirus (CMV pp65) or Wilms’ tumour 1 ...Differentiation in transduced cultures was ...cells to ... Voir le document complet
1
"Passenger Lymphocyte Syndrome” et “Host Versus Graft Reaction” après transplantation hépatique
... Dans le cas décrit ci‐dessus, l’hémolyse a été causée à J10 par les anticorps anti‐A produits par le greffon mais le titre de l’anti‐A dans l’éluat et le sérum du receveur a diminué dès [r] ... Voir le document complet
1
Selective Costimulation Blockade With Antagonist Anti-CD28 Therapeutics in Transplantation
... leads to T cell differentiation into pathogenic effector T cells (Teff), anti-inflammatory regulatory T cells (Treg), or memory T ...T cell costimulatory/co-inhibitory molecules have been identified ... Voir le document complet
24
The eGVHD App has the potential to improve the accuracy of graft versus host disease assessment: a multicenter randomized controlled trial.
... how to achieve optimal control of the quality of the entered data and guarantee its privacy protection according to local ...laws. In conclusion, the eGVHD App shows superior accuracy for the GvHD ... Voir le document complet
10
NLRP3 controls ATM activation in response to DNA damage
... HAL Id: hal-03093041 https://hal.archives-ouvertes.fr/hal-03093041 Preprint submitted on 5 Jan 2021 HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, ... Voir le document complet
45
Toxic Epidermal Necrolysis and Graft-versus-Host Reaction: Revisiting a Puzzling Similarity.
... ). In each case, the epidermis was still present and in close contact with the ...fail to discriminate with confidence cutaneous GVHR from SCAR, immunohisto- chemistry targeting inflammatory cells, ... Voir le document complet
6
IL-7 pathway controls human T cell homing to the gut and culminates in inflammatory bowel disease mucosa
... HAL Id: inserm-02161048 https://www.hal.inserm.fr/inserm-02161048 Submitted on 20 Jun 2019 HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, whether ... Voir le document complet
2
Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4.
... according to GINA classification [19]. In patients, any inhaled corticosteroids and anti-hista- mines were discontinued 15 days before ...As controls, healthy non smoker individuals with normal lung ... Voir le document complet
11
Elevations of tumor necrosis factor-receptor-1 at day 7 and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning
... observed in 28, 8, and 9 patients, ...TBI in their conditioning regimen experienced grades II–IV acute GVHD, whereas 37 of 88 patients (42%) conditioned with 2 Gy TBI did ...GVHD in univariate and ... Voir le document complet
7
Rabbit ATG/ATLG in preventing graft-versus-host disease after allogeneic stem cell transplantation: consensus-based recommendations by an international expert panel
... prevention in Europe [ 4 ] with the highest evidence derived from RCTs, numerous non-RCTs, and ...GvHD, in particular cGvHD, after transplants from almost any donor types; the strongest evidence of ef ficacy ... Voir le document complet
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