Top PDF Bile acid metabolism and the pathogenesis of type 2 diabetes.
Bile acid metabolism and the pathogenesis of type 2 diabetes.
... but the currently available strategies for therapy and prevention are ...that bile acid homeostasis is altered in T2D. Bile acids are metabolic regulators that act as signaling ...
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Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia and NAFLD Short title: Bile acids in meta-inflammatory disorders
... thermogenesis, and PPARγ coactivator-1α (PGC-1α), a regulator of mitochondrial biogenesis 73 ...FXR and TGR5 may be involved in the metabolic improvement induced by ...VSG. The impact ...
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Title: Bile acid alterations in non-alcoholic fatty liver disease, obesity, insulin resistance and type 2 diabetes: what do the human studies tell?
... for the treatment of NAFLD, it remains undetermined whether BAs are a driving force in the pathogenesis and progression of NAFLD or just innocuous ...bystanders. The ...
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Pathophysiology of type 2 diabetes.
... ABSTRACT Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat ...metabolism. The causes of type 2 ...
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Type 2 diabetes mellitus and osteoarthritis
... to the pathogenesis of T2DM, is characterized by reduced rates of insulin-mediated glu- cose uptake ...resistance, and in vitro studies show that glucose-induced insulin resistance ...
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Does pre-existing type 1 and type 2 diabetes during pregnancy lower docosahexaenoic acid and arachidonic acid in the umbilical cord blood of newborns and thus interfere with neurodevelopment?
... Th is absence of ev idence for impa ired neurodeve lopmen t in the neona tes from the d iabe t ic group occur red desp i te ev idence for lower AA trans fer f rom mo the r[r] ...
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Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice
... Abstract The nuclear bile acid receptor FXR (farnesoid-X-receptor) has recently been implicated in the pathophysiology of non- alcoholic fatty liver disease because selective ...
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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
... Effects of chronic AMPK ...for the acute glucose‐lowering effect of metformin, chronic metformin‐induced AMPK activation might indirectly inhibit hepatic glucose production by increasing hepatic ...
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Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes
... chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in ...B. Bile acid alterations in nonalcoholic fatty liver disease, obesity, ...
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The endocannabinoid system: a promising target for the management of type 2 diabetes.
... degradation, the fatty acid amide hydroxylase (FAAH) and the monoacylglycerol lipase (MAGL) (figure 1) ...that the EC system is involved in the physiological regulation of ...
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Oxidative Stress and Obesity- and Type 2 Diabetes-Induced Heart Failure
... Effect of Rosmarinic Acid and Sinapic Acid on Oxidative Stress Parameters in the Cardiac Tissue and Serum of Type 2 Diabetic Female ...in Diabetes ...
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Virus infections in pathogenesis of type 1 diabetes
... mechanisms of CVB infection Much research effort is currently focused on defining the cellular and molecular mechanisms behind the epidemiological relationship between CVB4 infection ...
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TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload
... obesity and diabetes, 17 as well as for cholestatic liver ...in the liver repair field, BA- centred therapeutic strategies are still underexplored, awaiting for experimental ...how the BA ...
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Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes
... routes of 6 α-OH HCA (also known as γ-muricholic acid) differ between mammal ...α-hydroxylation of BAs in humans has not been extensively studied, it is known that HCA is produced in hepatocytes from ...
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Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes
... routes of 6 α-OH HCA (also known as γ-muricholic acid) differ between mammal ...α-hydroxylation of BAs in humans has not been extensively studied, it is known that HCA is produced in hepatocytes from ...
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The effect of exercise training on cholesterol and bile acid metabolism in ovariectomized rats
... group of Ovx rats fed a standard diet (Ovx-SD) to observe the effects of the diet and, on the other hand, compared to a group of Sham operated rats fed the ...
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The postprandial glucose and lipids metabolism state among obese patients with type 2 diabetes
... seeds, and grains generally increase post-prandial glucose PPG and triglycerides to a lesser degree than do processed ...broccoli and spinach, or fruits such as grapefruits and ...density ...
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Treatment of type 2 diabetes.
... risk and benefits As the prevalence of type 2 diabetes and the risk of severe side-effects of oral antidiabetic agents are markedly increased with ...
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Pharmacological prevention of type 2 diabetes.
... for the prevention of type 2 diabetes in high-risk individuals, especially those with IGT ...in the natural history of T2DM, recent studies have clearly demonstrated that ...
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Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications.
... for the deposit and dissemination of sci- entific research documents, whether they are pub- lished or ...not. The documents may come from teaching and research institutions in France or ...
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