Haut PDF The biasing of the 5-HT4 receptor as an antidepressant target
The biasing of the 5-HT4 receptor as an antidepressant target
... models of depression, changes in phosphorylation levels of CREB correlated to antidepressants (AD) ...In the case of RS67333 AD effects appear within 2- 3 days of ...treatment. ...
71
Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress
... behavior. The neural underpin- nings of stress-induced hypophagia and the mecha- nisms by which the brain prevents the transition from transient to persistent hypophagia remain unde- ...
11
5-HT(2B) receptors are required for serotonin-selective antidepressant actions.
... Abstract The therapeutic effects induced by serotonin-selective reuptake inhibitor (SSRI) antidepressants are initially triggered by blocking the serotonin transporter and rely on long-term adaptations ...
11
Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)
... selective 5-HT 4 R antagonists have been proposed to treat atrial fibrillation or irritable bowel syndrome (IBS) [3], most of the efforts were put to develop ...representative of the ...
35
The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.
... stripped of endogenous estrogens for 5 days using phenol red free medium containing 3% dextran-coated charcoal (DCC) treated FCS ...lysis of the cells, luciferase activity was measured using ...
29
The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies
... 5-HT 6 receptor agonist, WAY181187 (Loiseau et ...contradicts the data of another study which showed a significant improvement of working memory in rats treated with EMD386088 or with ...
59
Role of the N-terminal region in G protein-coupled receptor functions: negative modulation revealed by 5-HT2B receptor polymorphisms.
... namely the fact that an infinite variety of combinations of efficacy and affinity can describe any given curve to a full agonist (there is no unique value of efficacy that can be ...
45
Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex
... for the prefrontal cortex in clinical depression; however, it remains unknown whether excitation or inhibition of prefrontal cortical neuronal activity is associated with antidepressant ...indicators ...
10
An FPGA target for the StarPU heterogeneous runtime system
... kinds of processing units, from traditional multicore CPUs to GPU accelerators and coprocessors like the Intel Xeon ...with an API to express task parallelism from a C/C++ or Fortran ...meaning ...
9
Axonal Targeting of the 5-HT1B Serotonin Receptor Relies on Structure-Specific Constitutive Activation
... where the I3 of 5-HT 1B is replaced by the I3 of 5-HT 1A would read ...in the presence or absence of MβCD treatment, which inhibits spontaneous ...to the ...
21
Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression
... model of depression. The results are in line with the idea arising from numerous studies indicating that astro- cyte dysfunction plays a crucial role in pathogenesis of ...after the ...
11
en fr Interest of 5-HT4 receptors in Alzheimer’s disease : behavioral and electrophysiological preclinical studies on mice Intérêts des récepteurs 5-HT4 dans la pathologie Alzmeimer : étude préclinique comportementale et électrophysiologie sur tranche d'hippocampe de souris
... (multi target directed ligand) permettrait de contourner ce problème par le design de molécules capables d’agir sur différentes ...des 5-HT4R, le donécopride, a été développé récemment (Lecoutey et ...
288
The cytochrome bc1 complex as an antipathogenic target
... to the related com- pound CK-2-68 [3,139] .) The ELQ class, however, does have some limita- tions, most notably the class suffers from poor aque- ous solubility which in vivo is reflected in limited ...
19
The crystal and molecular structure of the tricyclic antidepressant chlorimipramine hydrochloride
... Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous ...
7
Impact of the front-of-pack 5-colour nutrition label (5-CNL) on the nutritional quality of purchases: an experimental study
... Additionally, the level of understanding can be consid- ered as high, given that the 5-CNL is yet an experimen- tal FOP nutrition label that has not been broadly disseminated on food ...
10
Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1
... regulates the subcellular localization, stability, and ac- tivity of a variety of ...sumoylation of the receptor is not re- sponsible for enhanced transcription because substitu- ...
10
Dynamic interactions of the 5-HT 6 receptor with protein partners control dendritic tree morphogenesis
... level of 5-HT 6 R constitutive activity toward both canonical Gs signaling and G protein–independent signaling, which depends on allosteric modulations by interacting ...one of the few ...
43
The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.: PPARalpha controls the expression of the sIL-1ra in liver
... describes the comprehensive reaction of the host to various types of injury, which is generally protective and aimed at promoting tissue ...repair. The inflammatory response is mediated ...
33
en fr Serotonin and emotional behaviours : developmental role of the 5-HT7 receptor Sérotonine et comportements émotionnels : rôle du développement du récepteur 5-HT7
... immunolabeling of immediate early genes (cFos/ Egr1) to evaluate the in vivo consequences on mPFC neural ...tested the effect of DREADD activation on intrinsic excitability, ...i.e., ...
133
Dibenzoazepine analogues : the electrophysiological properties of JL3, a potential atypical antidepressant
... In the present work, we have studied the influence of JL3 on the electrical activity of dorsal raphe serotonergic neurons, locus coeruleus noradrenergic neurons an[r] ...
4
