[PDF] Top 20 APRIL is overexpressed in cancer: link with tumor progression.

... associated with prognosis or tumor aggressiveness using online cancer gene expression ...analysis[32]. APRIL protein was detected in several human solid tumors[57] and normal epithelial ... Voir le document complet

... profiling is necessary or whether prognostication based on aneuploidy could also be performed with a limited panel of genes, we evaluated the difference in median expressions between the most ... Voir le document complet

... expressed relative to the levels of the β-actin transcripts and are the mean ± SD of 3 tumors. C, Explanted tumors were analyzed for Reptin and Ki67 expression by immunostaining. Senescence was assessed by measuring acid ... Voir le document complet

... It is widely admitted that hypoxia in PDA deters the establishment of an effective anti-tumor response ( 4 , 16 , 17 , 39 – 41 ...eighteen-gene tumor in flammation signature ( 52 ), we ... Voir le document complet

... profiles in response to cisplatin compared to controls (Supp ...response in vivo is not dependent on the p53-p21 ...which is associated with its cytotoxicity and anticancer activity ... Voir le document complet

... Expression in Triple-Negative Breast Tumors Reduces Growth and Metastasis In Vivo In order to evaluate the impact of asporin expression on TNBC growth and progression, we co-injected ... Voir le document complet

... reaction is a prominent feature of pancreatic cancer and constitutes up to 80% of the total tumor ...It is characterized by the presence mainly of cancer-associated fibroblasts (CAFs), ... Voir le document complet

... PRD is characterized by severe gastrointestinal ...chronic in flammation and activation of the profibrotic transforming growth factor beta (TGF β)/Smad pathway, which is a major contributor to the ... Voir le document complet

... expression in a cohort of adenocarcinoma NSCLC patients Kaplan-Meier survival curve for overall survival (OS) for the 144 adenocarcinoma patients divided in two groups according to the stratification of ... Voir le document complet

... it is necessary address new strategies for cancer understanding and ...example, tumor cell proliferation (observable phenomenon) can be correlated to oxygen concentration (another observable ... Voir le document complet

... and in vivo electroporation Male athymic nude Mice (Foxn1 nu/nu) (Harlan, Grannat, France) were used at the age of 7 ...performed in compliance with the European Convention for the Protection of ... Voir le document complet

... reproducibly in this cancer model, suggesting the existence of programs governing the emergence and maintenance of ...variation is a direct outcome of underlying genetic variation, consistent ... Voir le document complet

... respectively) in cachectic cancer patients and weight stable ...autophagy in tumor microenvironment in modulating the in flammatory ...response. In the tumor ... Voir le document complet

... Asselain, Y. Allory, C.C. Abbou, D.G. Albertson, J.P. Thiery, D.K. Chopin, D. Pinkel, and F. Radvanyi, Regional copy number-independent deregulation of transcription in cancer. Nat Genet 38 (2006) 1386-96. ... Voir le document complet

... National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA With the sequencing of the human genome completed the functional elucidation for all expressed genes has become the ... Voir le document complet

... expression is repressed by several oncogenes such as Ras, Jun, WT1, and Myc, and activated by the tumor suppressor P53 (Stenina-Adognravi, ...TSP1 in clinical tumors is associated with ... Voir le document complet

... Colorectal cancer arises from intestinal epithelial cells in a multistep process that extend over several years and leads to the progression from a normal mucosa to aberrant crypt foci to benign ... Voir le document complet

... results in macrophages infiltration that enhances tumor progression and suppresses CD8 (+) T lymphocytes-mediated antitumor ...immunity. In addition, HRS cells expressing CD74 receptor, bind ... Voir le document complet

... identified in advanced prostate cancer[1]. STEAP1 is highly expressed in human prostate cancer and is up-regulated in various cancers, including lung, bladder, colon, ... Voir le document complet

... 191 Nous avons établi une collaboration avec le Laboratoire de Chimie des Polymères Organiques afin de développer une nouvelle technique ciblant le CXCR3, pour inhiber ses effets dans la progression tumorale. ... Voir le document complet