[PDF] Top 20 Anti-HER2 vaccines: new prospects for breast cancer therapy.
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Anti-HER2 vaccines: new prospects for breast cancer therapy.
... year, breast cancer accounts for more than 400.000 new cancer cases and more than ...130.000 cancer deaths in Europe. Prognosis of non metastatic breast cancer ... Voir le document complet
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FHIT low /pHER2 high signature in non-small cell lung cancer is predictive of anti-HER2 molecule efficacy: A new NSCLC subclass eligible for HER2 therapy
... of HER2 in vivo in two series of human NSCLC cases including both adenocarcinomas and squamous cell carcinomas and in vitro in a panel of lung tumour cell ...high HER2 activation rate was not related to ... Voir le document complet
35
Specific Targeting of Caspase-9/PP2A Interaction as Potential New Anti-Cancer Therapy
... In breast cancers, PP2A has been reported to be involved in progression through various important signalling pathways; indeed, it has been reported that Her-2 receptor induced PP2A phosphorylation [45] that PP2A ... Voir le document complet
13
How to Optimise Extended Adjuvant Treatment with Neratinib for Patients with Early HER2+ Breast Cancer
... remains for some patients with HER2? breast cancers in the adjuvant setting given that approximately one third of them remain at risk of disease recurrence and metastasis following optimal adjuvant ... Voir le document complet
14
The human epidermal growth factor receptor 2 (HER2) in the breast cancer : from measurement to targeted treatment
... the HER2 (ERBB2) gene, which is located on the long arm of chromosome 17 ...(2). HER2 is an essential mediator of cell proliferation and differentiation in the developing embryo and in adult tissues ... Voir le document complet
334
CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients
... into HER2-BC3 PDX reduced tumor growth and tumor weight (Figures 4a and b), demonstrat- ing that the CXCR4 receptor remain active in Herceptin-resistant HER2 ...a new suitable therapeutic avenue ... Voir le document complet
13
Precision medicine for metastatic breast cancer.
... Medicine for Metastatic Breast Cancer Elise Deluche, MD, Elisa Onesti, MD, and Fabrice Andre, MD OVERVIEW Genomic studies have shown that large numbers of candidate targets are observed in ... Voir le document complet
6
[Combination of anti-EGFR and anti-HER2 antibodies: hope in pancreatic cancer treatment]
... EGFR, HER2, cancer, pancréas Abstract. Unresectable pancreatic cancer is still an extremely dismal ...conventional therapy using chemotherapy has no real effect on survival and new ... Voir le document complet
9
CD73 : cible thérapeutique dans le cancer de l'ovaire et le cancer du sein HER2+
... de HER2 semble être inversement proportionnelle au CMH de classe I diminuant ainsi la présentation antigénique aux lymphocytes T ...un anti-ErbB2 in vivo (536,537) et ont clairement été associés à une ... Voir le document complet
234
[Anti-EGFR and anti-HER2 monoclonal antibodies against pancreatic carcinomas]
... Biologie d’EGFR et HER2 La famille HER est composée de quatre récepteurs transmembranaires à activité tyrosine kinase dont l’EGFR et HER2 [1]. Seul EGFR possède des ligands naturels qui peuvent participer ... Voir le document complet
5
The Dilemma of HER2 Double-equivocal Breast Carcinomas
... of breast carcinoma patients, of whom ∼15% are deemed HER2-positive and may bene fit from anti-HER2 ...mendations for HER2 testing in breast carcinomas 2 led to important ... Voir le document complet
11
Antibody engineering for cancer therapy
... - Engineer and select antibody mutants for improved affinity and stability using yeast surface display - Purify soluble antibody fragments secreted from yeasts using affinity chromatogra[r] ... Voir le document complet
144
Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation.: Anti-HER3 antibodies in cancer therapy
... main cancer features and leads to the rapid therapeutic escape of tumor cells following the initial ...ErbB1), HER2, HER3 and HER4] and eleven ligands ... Voir le document complet
44
Development of parallel reaction monitoring (PRM)-based quantitative proteomics applied to HER2-Positive breast cancer
... method for the high resolution Q-Exactive mass spectrometer (Thermo Scientific ® ) was set up in data dependent mode to switch consistently between MS and ...respectively for precursors and fragment ions ... Voir le document complet
17
New Prospects on Vines
... Guégan, D., Maugis, P. A., 2009. Dealing With Vines Isues. Work in Progress. Joe, H., 1997. Multivariate Models and Dependence Concepts. Chapman & Hall, Lon- don, UK. Kupiec, P. H., 1995. Techniques for ... Voir le document complet
15
Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies
... generate HER2 mutant or control lentivirus, 293T cells were transfected to produce viral particles using FuGENE HD ( Promega #E2311) with VSV-G and ...tested for the presence of lentiviral particles using ... Voir le document complet
42
Hormonal Therapy Resistance and Breast Cancer: Involvement of Adipocytes and Leptin
... targets for cancer ...all breast cancer subtypes and predominantly in triple-negative cancers [ 25 ...and cancer cells, they managed to decrease proliferation, migration, invasion, and ... Voir le document complet
16
Hormonal Therapy Resistance and Breast Cancer: Involvement of Adipocytes and Leptin
... with breast cancer have been shown to promote proliferation, adhesion, and migration of mammary epithelial cells, contrary to the conditioned media from the adipose tissue of non-cancer patients, ... Voir le document complet
17
Molecular basis of anti-hormonal treatment and resistance in breast cancer
... 4.2 Breast cancer classification Currently using TNM classification for breast tumours is according to their extension of ...However, for making a treatment decision, the knowledge of ... Voir le document complet
140
Note on new prospects on vines
... 6 Conclusion In this paper, we estimated multivariate distributions in high dimensions using a new vine copula-based approach that builds upon the work of Aas et al. (2009) by taking advantage of the diversity of ... Voir le document complet
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