[PDF] Top 20 Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation.
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Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation.
... subjected to immunoblotting with Ku70 and BAX ...of Ku70 protein bands of treated samples to that of control cells, after being normalized to the respective BAX and represent the ... Voir le document complet
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The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism
... overexpressed in nonsmall-cell lung cancers (NSCLCs) and is associated with a poor ...rates to EGFR-TKIs observed in EGFR wild type led to the investigation of mechanisms ... Voir le document complet
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Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers.: Areg and gefitinib resistance in NSCLC
... Molecular resistance mechanisms affecting the efficiency of receptor tyrosine kinase inhibitors such as gefitinib in Non-Small Cell Lung Cancer (NSCLC) cells are not fully ... Voir le document complet
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TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727
... order to determine the role of TGF-βRII on pancreatic carcinogenesis in vivo, CAPAN-1/-2 TGF-βRII-KD8 and NT SC xenograft studies were carried ...TGF-βRII-KD8 cell lines for in vivo studies as ... Voir le document complet
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Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
... upregulated in mTECs upon Ag- specific interactions with CD4 + ...controlled by LTα, specifically in CD4 + thymo- cytes, since it was exacerbated in absence of LTα or when LTα1β2/LTβR ... Voir le document complet
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CRISPR-mediated interrogation of small cell lung cancer
... student in the lab, started in the lab at around the same time as I did, and has been a good friend throughout this whole ...great to have her in the lab as a fellow graduate student going ... Voir le document complet
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miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47
... leading to translational repression and/or mRNA ...targets in melanoma ...possible to predict biological targets of miRNAs by searching for the presence of conserved sites that match the seed ... Voir le document complet
7
The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential
... p53) in CSC forma- tion has been largely documented, the role of other p53 isoforms is still poorly ...isoform in embryonic stem cells, has been proposed to control pluripotency by ... Voir le document complet
11
TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727
... suppressor in the early stages but promoting metastasis in the advanced carcinoma [ 6 ...targeting by a monoclonal antibody is also effective at reducing metastasis [ 14 ...]. In our cellular ... Voir le document complet
18
p16INK4A inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos.
... INK4A in a lung adenocarcinoma case (× 200) C: Lack of p16 INK4A expression in a lung adenocarcinoma case (× 200) Figure ...gene in NSCLC ... Voir le document complet
3
Vγ9Vδ2 T Cells Activation Through Phosphoantigens Can Be Impaired by a RHOB Rerouting in Lung Cancer
... T cells against NSCLC cell ...here by PAg and not by other activator ...two cell lines, stabilization of the immunological synapse around TCR/BTN3A1 is thus coordinated by two ... Voir le document complet
15
Targeting Infrequent Driver Alterations in Non-Small Cell Lung Cancer
... HAL Id: inserm-03082472 https://www.hal.inserm.fr/inserm-03082472 Submitted on 18 Dec 2020 HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci- entific research documents, whether ... Voir le document complet
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IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.
... involved in inducing IRF-5. Hence, we incubated CD4 T cells purified from d14, d21, and d28 ...expression by flow ...described to induce IRF-5 in monocytes of systemic lupus ... Voir le document complet
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The RAS‐related GTPase RHOB confers resistance to EGFR‐tyrosine kinase inhibitors in non‐small‐cell lung cancer via an AKT‐dependent mechanism
... analysis to demonstrate that RHOB is an independent prognostic factor of PFS (P < ...second- to fourth-line (Fig 1F) ...PFS to EGFR-TKI, regardless of the line of EGFR-TKI therapy, indicating that ... Voir le document complet
14
ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4+T cells by plasmacytoid dendritic cells
... dendritic cells (pDCs) and CD4+ t cells promotes immunosuppression in breast carcinoma through the amplification of regulatory t cell (tregs) and interleukin-10-secreting CD4 + t ... Voir le document complet
4
Control of Both Myeloid Cell Infiltration and Angiogenesis by CCR1 Promotes Liver Cancer Metastasis Development in Mice
... reduced in CCR1-deficient ...made by Yang et al. in a model of induced hepatocellular carcinoma [12], although our data indicated that this effect was dependent on host CCR1 expression and not due ... Voir le document complet
11
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells
... and In Vivo Procedures Kras LSL-G12D/+ ; p53 flox/flox (KP) mice have been described (DuPage et ...crossed to KP mice to generate KP-R26 LSL-cas9 or ...used in all experimental groups ... Voir le document complet
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Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib
... effective in the treatment of ...acquired resistance gives important clues towards the development of therapies that could elicit long lasting ...confers resistance to BRAFi in melanoma ... Voir le document complet
14
Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells.
... B cell neoplasia characterized by the accumulation of clonal malignant plasma cells in the bone ...marrow. In the majority of patients, malignant plasma cells require mediators ... Voir le document complet
38
Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer
... capacity to dampen inflammation and to be immunosuppressive (Moore et ...suppressive cells that are produced at high levels in cancer, are defined in mice on the basis of ... Voir le document complet
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