[PDF] Top 20 Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans.

... keletal muscle insulin resistance is a strong risk factor of type 2 diabetes and cardiovascular dis- eases ...lead to lipid oversupply and increased flux of free fatty acids ... Voir le document complet

... observed in obese subjects an impairment of insulin ability to reduce whole-body protein breakdown (9, 10), whereas other reports have challenged this conclusion (11, ...12). In these studies, ... Voir le document complet

... PPARα in muscles develop glucose intolerance, and are insulin resistant even though they are protected from diet-induced ...(AMPK) activity as well as reduced glucose transporter GLUT4, MEF2A, ... Voir le document complet

... lipids and insulin sensitivity. All three lipid classes (TAG, DAG, and ceramides) were negatively correlated with insulin ...(18:1), and total saturated ceramide content were ... Voir le document complet

... Obesity and ensuing disorders are increasingly prevalent in young ...exposure to high-fat diets (HFD) and excessive lipid accumulation were recently suggested to impair skeletal ... Voir le document complet

... of insulin resistance and type 2 diabetes on the regulation of apelin and APJ in AT and skeletal muscle both in mice and ...humans. In a ... Voir le document complet

... difference in muscle lipase content in obese insulin-resistant men was accompanied by a lower DAGH activity, resulting in a 60% lower ratio of DAGH to TAGH ... Voir le document complet

... accumulating in muscle could play a causative role in IR, via activation of PKC and serine/threonine kinases that inhibit insulin signaling ...metabolism in skeletal ... Voir le document complet

... that in trained athletes, the influ- ence of the expression level of MCT1 and MCT4 may not be as pronounced in these subjects compared with the existing literature examining sedentary ...adds ... Voir le document complet

... exercise, and higher in lean than obese individuals; this parameter showed inter-individual variability, partly 2 because it reflects a balance of several processes ( see methods), among which perfusion ... Voir le document complet

... of insulin effect on glucose uptake as also recently published (37) during the revision process of this ...increase in the expression of IL-1  in adipose tissue during obesity could thus ... Voir le document complet

... protein and gene expression were studied in brain, liver and skeletal muscle of male adult ...GS in cerebral cortex and cerebellum were reduced by 32% and ... Voir le document complet

... internal and sarcomeric to external, toward extracellular matrix, in myofibers (Figure 1 ...distribution in myoblasts [ 66 , 67 ] may favor the transmission of external mechanical forces ... Voir le document complet

... (157) and does not alter the cellular AMP/ATP ratio ...allosterically and by inhibiting dephosphorylation of AMPK on a-Thr172 ...administration to ob/ob mice markedly lowered plasma glucose levels ... Voir le document complet

... vivo insulin stimulation and insulin signalling in skeletal muscle Male Wistar rats, fasted for 7 h prior to the experi- ments, were anaesthetised with sodium ... Voir le document complet

... important in vitro model of insulin resistance that we did not investigate in detail is fatty acid-induced insulin resistance ( Van Epps-Fung et ...of insulin stimulation ... Voir le document complet

... Materials and Methods Organotypic slice ...5- to 9-d-old rat ...described in detail by Jourdain et ...min and decapitated. Brains were removed and tissue blocks that included the ... Voir le document complet

... Skeletal Muscle Immunometabolism INTRODUCTION Skeletal muscle inflammation is triggered by multiple physiological and pathological ...macrophages and dendritic cells respond ... Voir le document complet

... ice, and stored at -70°C until further ...Biomedicals). In vivo glucose metabolism. Five to 7 days before the studies, indwelling catheters were placed into the jugular vein extending into the right ... Voir le document complet

... obesity and a healthy clinical and biological ...project, and these rules may affect some of the results ...no activity, thus we may record longer percentages of sedentary time than other ... Voir le document complet