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[PDF] Top 20 Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents

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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents

Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents

... To our knowledge, this is the first documented case where both loss and enhancement of DNA repair initiation has caused increased cell sensitivity to DNA damage co[r] ... Voir le document complet

298

Balancing repair and tolerance of DNA damage caused by alkylating agents

Balancing repair and tolerance of DNA damage caused by alkylating agents

... initiating DNA glycosylase can also sensitize cells to alkylating agents 57 ...because glycosylase levels are too high or APE levels are too low), the consequence is an ... Voir le document complet

33

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

... Abstract Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy ...repairing ... Voir le document complet

14

Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)

Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)

... exposure to oxidizing or alkylating agents gives rise to a higher density of mtDNA lesions compared to nuclear DNA [7-11], indicating a need to repair mitochondrial damage ... Voir le document complet

26

Coordinating partially-informed agents over state-dependent networks

Coordinating partially-informed agents over state-dependent networks

... as to employ Kaspi’s two-way source coding [8] instead of non-interactive Wyner-Ziv ...both agents, the set of implementable distributions Q can be derived when Condition (7) or (8) ... Voir le document complet

6

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

... cytometry Cell suspensions from LNs were stained with eBioscience Fixable Viability Dye eFluor 780 (Invitrogen) for 15 min, followed by 10 min blocking in PBS containing 5% normal mouse serum (NMS) and 2% Fetal ... Voir le document complet

20

Microtubules tune mechanosensitive cell responses

Microtubules tune mechanosensitive cell responses

... accordingly to perform cellular functions such as adhesion, migration and ...of cell adhesion and migration, the contribution of microtubules to mechanotransduction still remains ...(αTAT1) to ... Voir le document complet

40

RNA-Seq reveals genotype-specific molecular responses to water deficit in eucalyptus

RNA-Seq reveals genotype-specific molecular responses to water deficit in eucalyptus

... sample to a mean fragment size of 650 bp and ligated it to an adaptor, according to standard procedures ...discarded to eliminate potential ... Voir le document complet

19

Host cell responses induced by hepatitis C virus binding.: Host cell responses induced by HCV

Host cell responses induced by hepatitis C virus binding.: Host cell responses induced by HCV

... Xinhua Fang, Mirjam B Zeisel, Jochen Wilpert, Bettina Gissler, Robert Thimme, Clemens Kreutz, Thomas Maiwald, Jens Timmer, Winfried Kern,.. Johannes Donauer, et al.[r] ... Voir le document complet

4

Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy

Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy

... Immune responses to the vaccine strategies were different between the two arms of HVTN 068 trial, and no correlations between the CD4+ IL-2+ and CD8+ IFN- γ+ responses were observed in the group with ... Voir le document complet

11

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting

... Targeting Cell Cycle Checkpoints Checkpoint dysfunction represents a common molecular defect acquired during tumorigenesis ( 15 , 127 ), underlying the importance of its regulation in cancer ...with cell ... Voir le document complet

11

Field Trials Reveal Ecotype-Specific Responses to Mycorrhizal Inoculation in Rice

Field Trials Reveal Ecotype-Specific Responses to Mycorrhizal Inoculation in Rice

... response to inoculation is related to the composition and diversity of microbial communities [ 43 ...lead to a "functional complementarity" in the fungal exploration of nutrient niches ... Voir le document complet

18

IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

... and to a lesser extent PI3K signals even in the absence of exogenous IL-7 ...compared to control ...compared to control, without any particular Gene ontology enrichment ...related to leukocyte ... Voir le document complet

14

Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanics

Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanics

... each cell in the perinuclear ...threshold to 1 ...applying to the force curves, after the baseline correction, the Hertz spherical indentation model using a Poisson’s ratio of ...boundaries to ... Voir le document complet

44

[CD3-specific antibody-induced T-cell apoptosis and apoptotic cell uptake lead to CD3-specific antibody-induced tolerance]

[CD3-specific antibody-induced T-cell apoptosis and apoptotic cell uptake lead to CD3-specific antibody-induced tolerance]

... D’autres part, la protéine GYGF2 s’exprime dans le cerveau et présente donc un intérêt particulier, puisque pour la première fois des altérations du gène codant pour une protéine in[r] ... Voir le document complet

17

CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals

CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals

... T cell–depleted ...chemokines to classifying diverse conditions of donor sources and ...DTA to the complete data set from the three donor categories and three ...cohort responses to ... Voir le document complet

29

Cell-Based Biosensor to Report DNA Damage in Micro- and Nanosystems

Cell-Based Biosensor to Report DNA Damage in Micro- and Nanosystems

... chose to create the sensor in the NIH-3T3 cell line as it is a commonly used fibroblast cell line that is simple to culture, the DNA damage response has been extensively studied in these ... Voir le document complet

9

Commensal-specific immune responses at the intestinal mucosa

Commensal-specific immune responses at the intestinal mucosa

... resin to produce C-terminal amides (Advanced ChemTech) using a flow-based solid-phase peptide synthesizer at 60˚C, as ...amine to increase their stability by inhibiting proteolysis at the ... Voir le document complet

219

Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion

Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion

... reported to demonstrate higher ECM recruitment capacities than the EDA– isoform (Manabe et ...as to increase the FN concentration in the ECM, as suggested by previous work (McKeown-Longo and Etzler, 1987; ... Voir le document complet

20

The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent

The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent

... cells to determine their nuclear ...found to localize to small punctate structures broadly distributed throughout the nuclei (Figure 4B), while as the cells progressed further through the S-phase, ... Voir le document complet

15

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