[PDF] Top 20 Akt signaling pathway: a target for radiosensitizing human malignant glioma
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Akt signaling pathway: a target for radiosensitizing human malignant glioma
... to glioma radioresistance. These data indicate that Akt intercept node could be a more relevant therapeutic target than STAT3 for radiosensitizing human malignant ... Voir le document complet
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Phosphoinositide 3-Kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
... Ras-MAPK signaling in human cancer ...(2001). A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling ... Voir le document complet
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Lycorine inhibits melanoma A375 cell growth and metastasis through the inactivation of the PI3K/AKT signaling pathway
... > Malignant melanoma, one of the most aggres- sive skin cancers, has a very high mortality ...with a high efficiency and a low toxicity in a large number of ...Lycorine, a ... Voir le document complet
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MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes.
... Mangiola A, Ferracin M, Liu CG , et al. (2005) Extensive modulation of a set of microRNAs in primary ...Conti A, Aguennouz M, La Torre D, Tomasello C, Cardali S , et ...in human grade II-IV ... Voir le document complet
13
UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway
... is a positive correlation between PI3K/Akt activation and colon ...Hyper-activated Akt signaling and decreased expression of PTEN have been found in 60-70% of human colon cancer ... Voir le document complet
6
Approaches to Manipulate Ephrin-A:EphA Forward Signaling Pathway
... Ephexin-1, a member of the GEF family is an interesting target to manipulate ephrin-A forward signaling since it is a direct interactor of EphA cytoplasmic domain [ 58 ] and its ... Voir le document complet
24
en fr MIF/CD74 signaling pathway : a novel treatment target in Pulmonary Arterial Hypertension (PAH) MIF/CD74 : une nouvelle cible thérapeutique pour l’Hypertension Artérielle Pulmonaire (HTAP)
... Il a été montré que l’expression pulmonaire de ce récepteur était diminuée chez les patients présentant une HTAP héritable ainsi que chez ceux présentant une HTAPi par rapport à des sujets sains (Atkinson et ...Il ... Voir le document complet
262
New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?
... (STAT3) signaling pathway, resulting in an increase of the expression of matrix metalloproteinase (MMP) 2 and MMP9 [ 32 ...with a good prognosis in osteosarcoma patients [ 35 , 36 ...with a ... Voir le document complet
23
SHH Signaling Pathway Drives Pediatric Bone Sarcoma Progression
... immortalized human mesenchymal stem cells stimulated their proliferation, reinforcing a role for Gli2 in osteosarcoma genesis as osteosarcoma cells are of mesenchymal ...induce a decrease in ... Voir le document complet
17
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.
... and a decrease in cells expressing the luminal marker CK18, indicating an expansion of primitive ...by a lack of ERa ...be a precursor of DCIS (ductal carcinoma in situ) and invasive ductal carcinoma ... Voir le document complet
15
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
... on a CR-fed diet had increased mean and maximum lifespan compared with those on an ad libitum- fed diet ...Therefore, human subjects included in this study were middle-aged men and ... Voir le document complet
8
Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in Arabidopsis
... Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous ... Voir le document complet
37
Sparc-like protein 1 is a new marker of human glioma progression.
... °C for 20 min. This was followed by a 5 min quenching step using 50 mM Tris-HCl (pH ...containing a protease inhibitor cocktail (Protease Inhibitor Cocktail 100x, Thermo Fisher Scienti fic, Waltham, ... Voir le document complet
11
A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
... Plexin-B1–Sema4A signaling correlates with a promigratory effect toward higher Plexin-B1 ...requires a tight spatiotem- poral coordination of Rho-GTPase activities (Raftopoulou and Hall, ...active ... Voir le document complet
18
Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes
... Cell Signaling, Beverly, MA, USA) at RT for 1 ...ning a ratio between their amount and that of ...Cell Signaling (Beverly, MA, USA) ... Voir le document complet
5
Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
... about a tumor-suppressing role of the TGFβ pathway in ...RBE human CCA cells exhibited elevated apoptosis, a process that was SMAD-dependent and augmented by inhibition of the c-Jun N-terminal ... Voir le document complet
18
JTC-801 Suppresses Melanoma Cells Growth through the PI3K‑Akt‑mTOR Signaling Pathways
... DMSO for 24 h and were lysed using ice-cold RIPA-based lysis buffer supplemented with protease ...boiled for 5 min after protein concentration in the cell lysates was quantitatively measured with a ... Voir le document complet
7
Cross talk between fanconi anemia and unc5a signaling pathway
... is a developmental deficiency disease, suggesting that FA proteins have functions other than those associated with DNA damage repair, for instance, in tissue ...FANCC, a predominantly cytoplasmic ... Voir le document complet
141
A lymphotoxin-driven pathway to hepatocellular carcinoma.: Sustained hepatic LT signaling causes HCC
... analysis for mRNA expression in liver of candidate genes at the age of 3 ...in a log2 scale ( blue : upregulated; red : ...of a particular gene resulting from 3-4 technical replicates, normalized to ... Voir le document complet
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TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia
... was a two- phase process consisting of a first step of Ca 2+ release that is dantrolene resistant and a second step that is inhibited by dantrolene, which is a known inhibitor of RYR1 ... Voir le document complet
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