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Voltage-gated potassium channels

Voltage-gated ion channels and gating modifier toxins.

Voltage-gated ion channels and gating modifier toxins.

... for voltage-sensor trapping In order to gain insight into the three-dimensional structure of the -scorpion toxin/sodium channel complex, we modeled the β three-dimensional structure of the toxin-receptor complex ...

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Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

... of voltage gated K + channels are important regulators of neuronal and cardiac action potential firing (excitability) and have major roles in human diseases such as epilepsy, schizophrenia, cancer ...

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Voltage-gated sodium channels assemble and gate as dimers

Voltage-gated sodium channels assemble and gate as dimers

... sodium channels are expressed across exci- table cells where they are crucial for sharp initiation dynamics and propagation of the action potential 1 ...other voltage- gated sodium channel genes have ...

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Gene regulation by voltage-dependent calcium channels.

Gene regulation by voltage-dependent calcium channels.

... above, Voltage-gated calcium channels and link with Ca 2 + -regulated transcription factors transcription factor activity was under the dependency of Ca 2 + -binding proteins such as ...L-type ...

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Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features.

Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features.

... channels co-expressed with wild-type Ca V α 2 δ -1 (filled circles), its proteolysis mutants E944Q, P4 and P6 or without any α 2 δ subunit (open circles). Currents were recorded after conditioning pulses of 1 s ...

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High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons.

High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons.

... Electrophysiological recordings Slices were visualized using a dissecting microscope and the re- cording electrode was precisely positioned in the STN. Electrophys- iological recordings of STN neurons were performed in ...

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Differential sensitivity of two insect GABA-gated chloride channels to dieldrin, fipronil and picrotoxinin

Differential sensitivity of two insect GABA-gated chloride channels to dieldrin, fipronil and picrotoxinin

... chloride channels; it may be poss- ible to exploit such differences to design more selective insecticides but these receptor proteins in insects need a better pharmacological ...

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Computational study of the structure-function relationship of Kir3 channels and applications to the design of light-gated Kir3 channels

Computational study of the structure-function relationship of Kir3 channels and applications to the design of light-gated Kir3 channels

... Kir3 channels and was most probably the reason for the changes in the agonist-induced ...Kir3.1/Kir3.4(I111C) channels were very active the next day, while increasing the amount of injected mRNA, as ...

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ATP-Sensitive Potassium Channels Exhibit Variance in the Number of Open Channels below the Limit Predicted for Identical and Independent Gating

ATP-Sensitive Potassium Channels Exhibit Variance in the Number of Open Channels below the Limit Predicted for Identical and Independent Gating

... two channels were observed to be open ...open channels is independent of the state of the other channel (the ratio of open dwell times when the other channel is closed/open is ...for channels ...

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Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b

Identification and characterization of two zebrafish Twik related potassium channels, Kcnk2a and Kcnk2b

... Discussion Here we have identified two zebrafish orthologs of KCNK, namely kcnk2a and kcnk2b. Both orthologs are highly homologous to their human counterpart including many known KCNK2 regulatory residues. Furthermore, ...

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Contribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis.

Contribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis.

... experiments were performed to assess expression and functionality of P2X1 ion channels. P2X1-mediated actin cytoskeletal reorganization was analyzed by confocal microscopy. Neutrophil migration was studied in ...

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Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

... the voltage dependence of α1 and α2 GlyRs block by NFA motivated us to implement the Woodhull analysis to determine the fractional electrical distance (δ) from the external side of the membrane at which NFA ...

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Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation.

Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation.

... Although these results show that β 4 dependent regulation of several genes coincides with β 4 nuclear targeting, it is clear that other neuronal differentiation factors may also be i[r] ...

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Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.: Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.: Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin

... in voltage-sensor trapping and ß-scorpion toxin action - Mutations of the positively charged and hydrophobic amino acid residues in the IIS4 segment do not alter the binding affinity of Css IV for its receptor ...

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Dysfunction of the Voltage-Gated K+ Channel beta 2 Subunit in a Familial Case of Brugada Syndrome

Dysfunction of the Voltage-Gated K+ Channel beta 2 Subunit in a Familial Case of Brugada Syndrome

... 7. Gulbis JM, Mann S, MacKinnon R. Structure of a voltage-dependent K + channel beta subunit. Cell. 1999;97:943 –952. 8. Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang C-E, ...

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Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

... the channels, we generated hTWIK1-AA, mTASK3, and mTREK1 channels harboring HA-epitope tags in their extracellular Ph2 to M4 loops, and C-terminal GFP fluorescent ...mutant channels, labeled with ...

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Suppression of Voltage-Gated L-type Ca2+ Currents by Polyunsaturated Fatty Acids in Adult and Neonatal Rat Ventricular Myocytes

Suppression of Voltage-Gated L-type Ca2+ Currents by Polyunsaturated Fatty Acids in Adult and Neonatal Rat Ventricular Myocytes

... effect of EPA. Eicosatetraynoic acid (5 mM) significantly inhibited I Ca,L , but its potency on I Ca,L was much less (P , 0.01) than that of EPA. All these PUFAs had similar effects on the F IG . 1. Suppressant effect of ...

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A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels

A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels

... P2X2 receptors are one subtype of the seven known P2X re- ceptors that can all form homomeric or heteromeric ATP-gated channels widely distributed in CNS and periphery ( Saul et al., 2013 ). In the ...

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Voltage-activated ion channels and Ca2+-induced Ca2+ release shape Ca2+ signaling in Merkel cells

Voltage-activated ion channels and Ca2+-induced Ca2+ release shape Ca2+ signaling in Merkel cells

... all whole-cell recordings to preserve endogenous Ca 2+ buffers [ 20 ]. To prevent amphotericin B from entering the bath prior to seal formation, pipette tips were filled with internal solution and the backs of pipettes ...

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BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells

BPDZ 154 is a potent activator of ATP-sensitive potassium channels in pancreatic b-cells

... KATP channels by ...SUR1/Kir6.2 channels over non-beta-cell KATP channels these types of compounds may offer a therapeutic potential in the future treatment of ...

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