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voltage-gated calcium channels

Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels.

Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels.

... Until now, the molecular insights on migraine pathophysiology came from studies on familial hemiplegic migraine (FHM), a monogenic subtype of migraine with aura. FHM can be considered a model for common migraine, because ...

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T-type calcium channels in neuropathic pain

T-type calcium channels in neuropathic pain

... ion channels in pain pathways are extremely ...ion channels in peripheral sensory neurons in Dorsal Root Ganglia (DRG) known now to express unique sets of these ...ion channels, we and others ...

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Gene regulation by voltage-dependent calcium channels.

Gene regulation by voltage-dependent calcium channels.

... above, Voltage-gated calcium channels and link with Ca 2 + -regulated transcription factors transcription factor activity was under the dependency of Ca 2 + -binding proteins such as ...L-type ...

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Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features.

Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features.

... 5. Bernstein GM, Jones OT. (2006) Kinetics of internalization and degradation of N-type voltage-gated calcium channels: Role of the α2/δ subunit. Cell Calcium (in press). 6. Brodbeck J, ...

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How do T-type calcium channels control low-threshold exocytosis?

How do T-type calcium channels control low-threshold exocytosis?

... low-voltage-gated calcium channels via distinct molecular ...of voltage-gated calcium channels highlighting the localization of the synprint site located within the ...

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Voltage-gated ion channels and gating modifier toxins.

Voltage-gated ion channels and gating modifier toxins.

... sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent ...These channels ...

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Contribution of calcium-conducting channels to the transport of zinc ions.

Contribution of calcium-conducting channels to the transport of zinc ions.

... 24. Gibon, J., Tu, P., Bohic, S., Richaud, P., Arnaud, J., Zhu, M., Boulay, G. and Bouron, A. The over-expression of TRPC6 channels in HEK-293 cells favours the intracellular accumulation of zinc. Biochim Biophys ...

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Voltage-Sensor Probes as efficient tools to screen for new modulators of voltage-gated sodium channels

Voltage-Sensor Probes as efficient tools to screen for new modulators of voltage-gated sodium channels

... ion channels are confined to primary afferent neurons where they likely contribute to the detection and transmission of different kinds of nociceptive ...T-type calcium channel ...

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Molecular Characterization of Voltage-Gated Sodium Channels and Their Relations with Paralytic Shellfish Toxin Bioaccumulation in the Pacific Oyster Crassostrea gigas

Molecular Characterization of Voltage-Gated Sodium Channels and Their Relations with Paralytic Shellfish Toxin Bioaccumulation in the Pacific Oyster Crassostrea gigas

... to voltage-gated sodium channels (Nav) and block conduction of action potential in excitable ...sodium/calcium-selective channels, ...

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Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

... modulate voltage dependent gating; profoundly influencing the time course and amplitudes of potassium currents during physiological processes such as action ...the voltage sensor, C-linker and channel pore ...

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Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity

Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity

... ion channels together with RyR 2 , the SR calcium pump SERCA and the Na + /Ca 2+ exchanger ...transmembrane voltage during a spontaneous action potential (AP) generated by a computational model of ...

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Physiological involvement of presynaptic L-type voltage dependent calcium channels in GABA release of cerebellar molecular layer interneurons

Physiological involvement of presynaptic L-type voltage dependent calcium channels in GABA release of cerebellar molecular layer interneurons

... BK channels for timing and regulating cell ...the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell- specific expression in the cerebellar ...

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Computational study of the structure-function relationship of Kir3 channels and applications to the design of light-gated Kir3 channels

Computational study of the structure-function relationship of Kir3 channels and applications to the design of light-gated Kir3 channels

... Kir3 channels and was most probably the reason for the changes in the agonist-induced ...Kir3.1/Kir3.4(I111C) channels were very active the next day, while increasing the amount of injected mRNA, as ...

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High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons.

High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons.

... Beurrier, Corinne, Bernard Bioulac, Jacques Audin, and Con- stance Hammond. High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons. J Neuro- physiol 85: ...

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Differential sensitivity of two insect GABA-gated chloride channels to dieldrin, fipronil and picrotoxinin

Differential sensitivity of two insect GABA-gated chloride channels to dieldrin, fipronil and picrotoxinin

... chloride channels after the receptors were activated; the picrotoxinin- and dield- rin-site is exposed by a conformational change initiated by GABA binding to the receptor (use-dependent ...homomeric ...

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Determining the distribution of calcium channels in the olfactory system

Determining the distribution of calcium channels in the olfactory system

... In this paper we study the inverse problem which consists in finding the spatial distribution of CNG ion channels from the experimental current data. This problem comes down to solving a Fredholm integral equation ...

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Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid

... the voltage dependence of the block; (ii) increase of the α1 GlyR blocking efficacy with the increased glycine concentration; (iii) appearance of high frequency interburst flickering upon NFA application revealed ...

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Voltage- and cold-dependent gating of single TRPM8 ion channels

Voltage- and cold-dependent gating of single TRPM8 ion channels

... one voltage and simultaneous (global) fitting to data obtained at multiple ...versus voltage plots. The voltage dependence of the different rate constants at one fixed temperature was determined from ...

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Contribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis.

Contribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis.

... Contribution of ATP-gated P2X1 ion channels to the control of neutrophil chemotaxis C. Lecut 1 , K.Frederix 1 , D. Johnson 2 , C. Faccinetto 1 , P. Volders 2 , V. Bours 1 , C. Oury 1 . 1 GIGA-Research, ...

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Voltage-gated sodium channels assemble and gate as dimers

Voltage-gated sodium channels assemble and gate as dimers

... two channels missing the C-terminus are still clearly interacting with them- selves or with the WT channel even though the interaction region described by Gabelli et ...these channels will lead to an ...

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