visceral hypersensitivity
Bifidobacterium longum and Lactobacillus helveticus synergistically suppress stress-related visceral hypersensitivity through hypothalamic-pituitary-adrenal axis modulation
... decreases visceral hypersensitivity induced by chronic stress in response to low noxious stimuli, but the combination of these 2 probiotics was more effective in stressed mice at all volumes of ...
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Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models
... rat visceral hypersensitivity models, both agonists suppressed the TNBS-induced increase in abdominal contractions in response to colorectal distension without affecting the colonic wall elasticity, and ...
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Early life stressful events impaired enteric antimicrobial activity and triggered commensal E. coli overgrowth responsible for visceral hypersensitivity in adult mice
... EARLY LIFE STRESSFUL EVENTS IMPAIRED ENTERIC ANTIMICROBIAL ACTIVITY AND TRIGGERED COMMENSAL E. COLI OVERGROWTH RESPONSIBLE FOR VISCERAL HYPERSENSITIVITY IN ADULT MICE A. Riba 1 , M. Olier 1 , S. ...
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Stress-induced visceral hypersensitivity in female rats is estrogen-dependent and involves tachykinin NK1 receptors
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice
... in visceral hypersensitivity which persist more than 14 days in mice 34 and at least 28 days 35 in rats, a period of time at which it could be assumed that effector T lymphocytes (generated in response to ...
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Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation
... mechanical hypersensitivity following intraplantar CFA ...of visceral hypersensitivity to mechanical ...pain hypersensitivity induced by intraplantar injections of inflammatory mediators ...
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Visceral perception: inflammatory and non-inflammatory mediators
... SUMMARY Visceral hypersensitivity is currently the most widely accepted mechanism responsible for ab- dominal pain and contributes to intestinal motor abnormalities in functional gastrointestinal dis- ...
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Centrally acting agents and visceral sensitivity
... reducing visceral noci- ...by visceral stimulation and its long term consequences confirms that the CNS remains a privileged target for reducing visceral ...
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Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
... mechanical hypersensitivity Expression analysis revealed that TRPM8 and TRPA1 channels were minimally affected, although TRPA1 was found to be slightly ...mechanical hypersensitivity in neuropathic ...
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Adherent-Invasive E. coli enhances colonic hypersensitivity and P2X receptors expression during post-infectious period
... Figure 5. CD-associated AIEC LF82 bacteria induce colonic hypersensitivity in CEABAC10 transgenic mice. (A) Visceromotor response (VMR) to colorectal distension test at D4 and (B) corresponding AUC of the ...
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Acute and chronic stress differently affect visceral sensitivity to rectal distension in female rats
... Acute and chronic stress differently affect visceral sensitivity to rectal distension in female rats.. Bradesi, Hélène Eutamene, Rafael Garcia Villar, J.[r] ...
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Fecal dysbiosis associated with colonic hypersensitivity and behavioral alterations in chronically Blastocystis-infected rats
... Colorectal distension (CRD) test. This test assesses visceral sensitivity by measuring the response of the colon when submitted to distension. The CRD protocol was adapted for rats from Larauche et al. 63 . At ...
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Comparative effects of alpha 2 delta-1 ligands in mouse models of colonic hypersensitivity
... of visceral sensitivity, mice were sub cutaneously injected with a first dose of anticonvulsants (GBP 30 mg/kg, PGB 10 mg/kg and CBZ 10 mg/kg) and their effects on colonic sensitivity were assessed 1h later ...
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Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back
... Drug hypersensitivity reactions (DHR) have been present since the advent of ...delayed-type hypersensitivity reactions represent a heterogeneous clinical entity with a diverse pathogenesis and result in a ...
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Visceral Fat Accumulation During Lipid Overfeeding Is Related to Subcutaneous Adipose Tissue Characteristics in Healthy Men
... and visceral adi- pose tissue depots during overfeeding, one of the unexpected results was the finding that there was no relationship between their respec- tive ...in visceral fat and the evolution of body ...
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Routine clinical measures of adiposity as predictors of visceral fat in adolescence : a population-based magnetic resonance imaging study
... Further, obesity-related risk for CMD increases not only with the quantity but also with a specific distribution of body fat – individuals who store body fat viscerally rather than elsewhere in the body (mostly ...
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Inhibition of cystathionine-γ-lyase controls interleukin-12 production by dendritic cells, delayed-type hypersensitivity and transplant rejection
... Methods and results In the current study, we demonstrated that pharmacolo- gical blockade of CSE with the irreversible inhibitor pro- pargylglycine (PPG) delayed heart allograft rejection (median survival of 26.5 days ...
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Inhibition of Ca v 3.2 calcium channels: A new target for colonic hypersensitivity associated with low‐grade inflammation
... FIGURE 5 Inhibition of Ca V 3.2 channels located on the spinal terminals of C ‐fibres reduced colonic hypersensitivity. Different groups of mice received dextran sodium sulfate (DSS) for 12 days. Colonic ...
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Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America
... Drug, Hypersensitivity, Allergy, Diagnosis, Skin test, In vitro test, IgE, T-cells, Drug provocation test, Sensitization, United States, Europe © The Author(s) ...
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TAFA4, a Chemokine-like Protein, Modulates Injury-Induced Mechanical and Chemical Pain Hypersensitivity in Mice
... chemical hypersensitivity following inflammation and nerve injury as well as increased excitability of spinal cord lamina IIi neurons, which could be reversed by intrathecal or bath application of recom- binant ...
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