Vascular smooth muscle
Modulation of Endothelin-1 and Insulin-like Growth Factor Type 1-induced Signaling by Curcumin in A-10 Vascular Smooth Muscle Cells
... in vascular smooth muscle cell (VSMC), including protein kinase B (PKB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathways, as well as an increase in ET-1-mediated VSMC hypertrophy ...
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Redox regulation of ET-1-induced activation of ERK1/2, PKB and Pyk2 signaling in A-10 vascular smooth muscle cells
... Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II induced mitogen-activated protein kinase activation in vascular smooth muscle ceils. Yamagu[r] ...
161
LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation
... and vascular calcification ...these vascular disorders, we used cultured human vascular smooth muscle cells, either overexpressing the same LMNA mutations or treated for long-term with ...
36
Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension
... whether vascular ADORA2B could contribute directly to the development of PH in an in vivo ...off vascular smooth muscle ADORA2B is able to prevent HX-SU and BLM induced PH without altering ...
19
Lipid Loading of Human Vascular Smooth Muscle Cells Induces Changes in Tropoelastin Protein Levels and Physical Structure
... human vascular smooth muscle cells (VSMC), which are major producers of elastin in the vascular ...human vascular cells leads to an increase in cathepsin S production concomitantly with ...
10
Plasminogen activator inhibitor-1 impairs plasminogen activation-mediated vascular smooth muscle cell apoptosis
... Plasmin-mediated vascular smooth muscle cell apoptosis Exposure of WT, t-PA -/- , u-PA -/- or PAI-1 -/- VSMC to plasminogen (1.25 to 10 µM) for 72 h was associated with a concentration-dependent ...
23
The Effect of Resveratrol on the Hyperproliferation of Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats : Molecular Mechanisms
... ABSTRACT Vascular remodeling due to the hyperproliferation and hypertrophy of vascular smooth muscle cells (VSMCs) is central in the development of ...
136
PKB mediates Insulin-Like Growth Factor 1-induced phosphorylation and nuclear export of Histone Deacetylase 5 via NADPH Oxidase 4 activation in vascular smooth muscle cells
... increased vascular resistance due to blood vessel ...by vascular smooth muscle cells (VSMCs), which are highly specialized cells that regulate vascular tone and blood pressure ...of ...
118
Regulation of the Early Growth Response Protein-1 in vascular smooth muscle cells
... of vascular dysfunction ...cause vascular damage ...in vascular lesion formation, an ultimate event in the atherogenic process ...in vascular disease, it is also being considered as an immune ...
196
Natriuretic peptide receptor-C activation regulates vascular smooth muscle cell hypertrophy : molecular mechanisms
... 1.6.1.2.1 VSMC Hypertrophy: Implication of Gq α Studies on mutations of Gqα and G11α in mice have highlighted their importance in cardiovascular growth and development (Offermanns et al., 1998). In essence, mice that had ...
136
Identification of target antigens of anti-endothelial cell and anti-vascular smooth muscle cell antibodies in patients with giant cell arteritis: a proteomic approach.
... Abbreviations ACR: American College of Rheumatology; AECA: anti-endothelial cell antibody; ANCA: antineutrophil cytoplasm antibody; bFGF: basic fibroblast growth factor; CSS: Churg-Strauss syndrome; EC: endothelial cell; ...
16
Characterisation of Calcium Phosphate Crystals on Calcified Human Aortic Vascular Smooth Muscle Cells and Potential Role of Magnesium
... To our knowledge, for the first time, the crystal formation and the possible role of Mg 2+ in VC through an in vitro model of primary human aortic vascular smooth muscle cells (HAVSMC) was ...
18
Assessing the Activity of Agonistic Autoantibodies in Systemic Sclerosis and their Effects on Cultured Vascular Smooth Muscle Cells
... several vascular changes that affect all three layers ...(endothelial, smooth muscle and fibroblast) in the pulmonary vascular wall plays a specific role in the pathogenesis (Humbert, ...
87
Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression.
... Abstract Leukotrienes are pro-inflammatory mediators that are locally produced in coronary atherosclerotic plaques. The response induced by cysteinyl leukotrienes (CysLT) in human coronary arteries may be altered under ...
10
The nucleus of human vascular smooth muscle cells contains nuclear t-tubules and nucleoplasmic reticulum and regulates its own calcium homeostasis
... the results obtained in isolated aortic nuclei, in hepatic nuclei DiOC6 showed sorne fluorescence on the nuclear envelope, without any distinct labeling of nucleoplasmic [r] ...
311
Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor
... 1.2.4.3. Platelet-Derived Growth Factor (PDGF) and its Receptors Platelet-derived growth factors are homo- and hetero-dimeric proteins secreted by platelets and many other cell types, including fibroblasts, endothelial ...
138
Hydrogen peroxide enhances the expression and function of Giα proteins in aortic vascular smooth muscle cells from Sprague-Dawley rats : role of growth factor receptors transactivation
... via the phosphorylation of growth factor receptors EGF-R, and PDGFR-β, which in turn activate downstream signalling pathways including ERK1/2, and PI3K. The induction of the above pathways may trigger transcription of ...
109
Expression of receptors for human angiogenin in vascular smooth muscle cells
... physiological action of angiogenin would depend on modulatory mechanisms. High- affinity receptors could mediate cellular responses at low angiogenin concentrations, while low-affinity/high-capacity binding sites could ...
31
Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain
... Fluorescent in situ hybridization confirms the differential expression of selected transcripts. In order to validate our transcriptomic data, we performed FISH experiments in freshly isolated cells (Fig. 3 ) and in ...
13
Upstream mechanisms responsible for H₂O₂-induced activation of MAPK and PKB in vascular smooth muscle cells
... Eguchi S, Numaguchi K, Iwasaki H, Matsumoto T, Yamakawa T, Utsunomiya H, Motley ED, Kawakatsu H, Owada KM, Hirata Y, Marumo F, and Inagami T, Calcium-dependent epidermal growth factor re[r] ...
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