Varicella-zoster virus
Varicella-zoster virus induces apoptosis in cell culture
... by varicella-zoster virus (VZV), a human herpesvirus, is characterized by nuclear fragmentation of DNA into oligonucleosomal fragments and by chromatin ...
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The varicella-zoster virus ORF47 kinase interferes with host innate immune response by inhibiting the activation of IRF3.
... during Varicella-Zoster Virus (VZV) infection has been poorly ...mutant virus unable to express the viral kinase ORF47p, we demonstrated that (i) IRF3 slower-migrating form disappears; (ii) ...
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Characterization of regulatory functions of the varicella-zoster virus gene-63-encoded protein
... Abstract Varicella-zoster virus (VZV) gene 63 encodes a protein (IE63) with a predicted molecular mass of ...simplex virus type 1. ICP22 is a polypeptide synthesized in herpes simplex ...
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The role of varicella zoster virus immediate-early proteins in latency and their potential use as components of vaccines
... Summary. Varicella zoster virus immediate-early (IE) proteins are intracellular regulators of viral gene ...elderly zoster-free individuals, CMI to IE 63 remained ...
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Varicella-Zoster Virus IE4 Protein Interacts with SR Proteins and Exports mRNAs through the TAP/NXF1 Pathway.
... Varicella-Zoster virus (VZV) is another alpha-herpesvirus encoding the IE4 protein which is homologous to the proteins described ...knockout virus has shown that IE4 is essential for infection ...
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Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects
... in varicella zoster virus (VZV) pathology, namely the long-standing wart-like skin lesions that are frequently associated with resistance to thymidine kinase (TK)-dependent antiviral ...
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Characterization of the regulatory functions of varicella-zoster virus open reading frame-4 gene-product
... Belgium Varicella-zoster virus (VZV) open reading frame 4 (ORF4) encodes a protein with a predicted molecular weight of 51,540 presenting amino acid sequence homology with the immediate-early ...
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Varicella-zoster virus IE63, a virion component expressed during latency and acute infection, elicits humoral and cellular immunity
... to varicella-zoster virus and its ...B. Varicella- relevance to vaccine ...75. zoster virus latency in the adult rat is a useful model for human latent ...of ...
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Distribution of varicella-zoster virus DNA and gene products in tissues of a first-trimester varicella-infected fetus.
... Figure 1. Detection of varicella-zoster virus (VZV) DNA in fetal tissue. Primers and probes were designed to enable fluorescence-resonance-energy transfer. The accumulating fluorescence (vertical ...
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Deletion of the ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids.
... The protein encoded by ORF9 is essential for varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and its involvement in secondary ...
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Varicella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency
... Laboratory of Fundamental Virology,Institute of Pathology, University of Liège, B-4000 Liège, Belgium [2] Laboratory of Dermatopathology Institute of Pathology, University of Liège, B-4000 Liège, Belgium Abstract : ...
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Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex
... Abstract Using transient transfection assays, regulation properties of Varicella-Zoster Virus (VZV)-encoded IE63 protein were analyzed on several VZV immediate early (ORF4), early (ORF28) and late ...
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Varicella-zoster virus open reading frame 4 encodes an immediate-early protein with posttranscriptional regulatory properties
... Belgium Varicella-zoster virus (VZV) encodes four putative immediate-early proteins based on sequence homology with herpes simplex virus type 1: the products of ORF4, -61, -62, and ...
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Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity.
... of Varicella-Zoster virus (VZV) infection, IE63 (immediate early 63 protein) is mostly expressed in the nucleus and also slightly in the cyto- plasm, and during latency, IE63 localizes in the cyto- ...
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Varicella-zoster virus modulates NF-kappaB recruitment on selected cellular promoters.
... in varicella-zoster virus (VZV)-infected melanoma cells (MeWo), leading to the following observations: (i) VZV inhibits the stimulation of icam-1 mRNA synthesis; (ii) despite VZV-induced nuclear ...
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Activation of the human immunodeficiency virus long terminal repeat by varicella-zoster virus IE4 protein requires nuclear factor-kB and involves both the amino-terminal and the carboxyl-terminal cysteine-rich region
... : Varicella-zoster virus open reading frame 4-encoded protein (IE4) possesses transactivating properties for varicella-zoster virus genes as well as for those of heterologous ...
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Varicella-Zoster virus gene expression in latently infected rat dorsal root ganglia.
... Words: Varicella-Zoster Virus (VZV); latency; dorsal root ...INTRODUCTION Varicella-Zoster virus (VZV) is a human herpesvirus which causes varicella (chickenpox) as a ...
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The Varicella-Zoster virus IE4 protein: a conserved member of the herpesviral mRNA export factors family and a potential alternative target in antiherpetic therapies
... A B S T R A C T During a viral infection, in addition to cellular mRNAs, amounts of viral mRNAs have to be efficiently transported to the cytoplasm for translation. It is now established that herpesviruses encode a ...
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Study of the role of the complex formed by the Varicella Zoster virus ORF9p and the cellular Adaptin Protein-1 in the secondary egress
... the Varicella Zoster virus ORF9p and the cellular Adaptin Protein-1 in the secondary egress Julien LAMBERT 1 , Marielle LEBRUN 1 , Laura RIVA 1 , Judit SÁNCHEZ GIL 1 , Graciela ANDREI 2 , Robert ...
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Varicella Zoster Virus ORF9p: hijacker of the autophagy pathway?
... Varicella Zoster Virus ORF9p: hijacker of the autophagy pathway? Lambert, J. 1 , Thiry, M. 2 , Sadzot-Delvaux, C. & Lebrun, M. 1 1 Laboratory of Virology and Immunology, GIGA-I³, University of ...
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