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UBIQUITIN-PROTEASOME-DEPENDENT PATHWAY

The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy

The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy

... The ubiquitin- proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle ...the ...

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Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

... fork. Pathway choice, in single-ended double-strand breaks, between most prevalent NHEJ and S-phase specific HR-mediated repair is yet to be ...Exo1- dependent resection at the 5’ of the broken strand ...

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Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells

Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells

... host ubiquitin proteasome system through deamidation of ubiquitin or the ubiquitin-like protein NEDD8 that regulates Cullin-Ring-ubiquitin Ligase (CRL) ...the ...

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The ubiquitin/26S proteasome system in plant-pathogen interactions: a never-ending hide-and-seek game

The ubiquitin/26S proteasome system in plant-pathogen interactions: a never-ending hide-and-seek game

... 26S proteasome. Proteasome inhibitors lead to an increased stability of this protein, which then accumulates in the endoplas- mic reticulum in a polyubiquitinated form (Reichel & Beachy, ...26S ...

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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

... 26S proteasome proteolytic function, we compared the levels of chymotrypsin-like activity in AIEC LF82 infected T84 cells with non-infected ...26S proteasome, and consequently increase its ability to ...

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Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells

Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells

... the ubiquitin-proteasome system ...First, ubiquitin is processed by the ubiquitin activating enzyme (E1) and then transferred to the ubiquitin conjugating enzyme ...the ubiquitin ...

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Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta.

Phosphorylation of activation function-1 regulates proteasome-dependent nuclear mobility and E6-associated protein ubiquitin ligase recruitment to the estrogen receptor beta.

... E6-AP ubiquitin ligase was found to be favorably recruited to ERd in response to signals that promote ERd ...strongly dependent upon the presence of Ser-94 and -106 which resulted in a more rapid ...

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Cascade profiling of the ubiquitin-proteasome system in cancer

Cascade profiling of the ubiquitin-proteasome system in cancer

... NF-κB pathway in NF-κB-dependent cancer cells; (4) suppression of tumor angiogenesis as a result of cell cycle arrest and accumulation of RhoA GTPase (Enchev et ...CRL/NEDD8 pathway as a therapeutic ...

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A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits

A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits

... S proteasome subunits (Table 1). The ␣7 proteasome sub- unit and HSP27 were identified in two different spots, thus supporting post-translational modifications (phosphorylation) previously described for ...

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The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells

... reniformis; DD, destabilizing domain of FK506 binding protein (FKBP); PEST, sequence rich in proline (P), glutamic acid (E), serine (S), and threonine (T) associated with short-lived proteins; the D433A and D434A PEST ...

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Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes

Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes

... transmission through other kinase cascades and might represent a general principle in scaffold- assisted signaling. Signaling complex assembly must be tightly controlled in both space and time. The use of protein ...

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Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.

... ineffective in preventing cell death in HL 60 cells [26]. This may be easily explained hypothesizing that Ub 0 may not inhibit PTP opening or may induce oxidative stress in HL 60 cells. Some tissue-specificities in PTP ...

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Microalgae synthesize hydrocarbons from long-chain fatty acids via a light-dependent pathway

Microalgae synthesize hydrocarbons from long-chain fatty acids via a light-dependent pathway

... biosynthetic pathway of plants has been partly eluci- dated (Lee and Suh, 2013; Bernard and Joubès, 2013), but the use of plant hydrocarbons as a renewable source of liquid fuels is hampered by predominance of ...

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BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.

BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.

... GSK3-dependent pathway that involves the phosphorylation of two C-terminal residues ...the proteasome and interacts with the proteasome subunit PSMB1 once phosphorylated by ...

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Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation

Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation

... As cultured vascular SMCs express the main Hh signaling pathway elements including Hh receptor Patched-1 (Ptch-1), Smoothened (Smo), and Glioma-associated oncogene 1 (Gli1) transcription factor (Fig. S2), we ...

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Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species

Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species

... * David.Barker@inra.fr Abstract Mutualistic plant-microbe associations are widespread in natural ecosystems and have made major contributions throughout the evolutionary history of terrestrial plants. Amongst the most ...

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Leishmania modulates phagosome fonctions by altering certain SNAREs in a GP63-dependent pathway

Leishmania modulates phagosome fonctions by altering certain SNAREs in a GP63-dependent pathway

... We found that V AMP8 is necessary for the recruitment of gp91pho.T on the phagosome membrane whereby the NADPH oxidase regulates cross-presentation in dendritic cells. In the s[r] ...

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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

... the proteasome and 10 control ...indicated proteasome subunits and their relative cell number following bortezomib ...two proteasome subunits (shPSMC5, shPSMD2) displayed significant growth ...

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Affinity Purification Strategy to Capture Human Endogenous Proteasome Complexes Diversity and to Identify Proteasome-interacting Proteins

Affinity Purification Strategy to Capture Human Endogenous Proteasome Complexes Diversity and to Identify Proteasome-interacting Proteins

... S proteasome complex, but the 19 S regulatory particles as well as other activators such as PA28 or PA200 are known to enhance the ChT-like proteolytic activity of 20 S ...that proteasome com- plexes ...

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E4F1 connects the Bmi1-ARF-p53 pathway to epidermal stem cell-dependent skin homeostasis.

E4F1 connects the Bmi1-ARF-p53 pathway to epidermal stem cell-dependent skin homeostasis.

... Bmi1-ARF-p53 pathway to epidermal stem cell-dependent skin homeostasis Julie Caramel, 1 Matthieu Lacroix, 1,2 Laurent Le Cam 2, * and Claude Sardet 1, * 1 Institut de Génétique Moléculaire de Montpellier; ...

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