Tyrosine phosphorylation
Bridging the gap between protein-tyrosine phosphorylation networks, metabolism and physiology in liver-specific PTP1b deletion mice
... Here, I highlight two classes of PTMs, tyrosine phosphorylation and lysine acetylation, that have recently been found to control cellular metabolism via direct modifi[r] ...
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An Evolution-Guided Analysis Reveals a Multi-Signaling Regulation of Fas by Tyrosine Phosphorylation and its Implication in Human Cancers
... (XLSX) S1 Fig. Tyrosine phosphorylation of Fas death domain is dispensable in FasL-induced apo- ptosis in human colorectal cancer cells. (A) SW480 cells stably expressing control protein (LacZ.V5) or ...
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Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth
... nonreceptor tyrosine kinases, especially c-Abl, as Cdk5 ence of c-Abl, and this was enhanced by inclusion of tyrosine ...Cdk5 tyrosine phosphoryla- and Cables as well as or better than wild-type ...
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Calcium- and tyrosine phosphorylation-dependent mechanisms of amyloid precursor protein processing
... Calcium influx induced with ionomycin mimicked the effects of muscarinic receptor activation with carbachol on tyrosine phosphorylation and on APPs secretion.. These ef[r] ...
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Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells
... Source code 1). Gene sets of Figure 2 were selected according to each experiment mean distribu- tion except for MNase-seq and RNA-seq whose selections were based on Pol II. For Figure 2—figure supplement 4 , a less ...
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Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissues.
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Phosphorylation and circadian molecular timing
... the phosphorylation state (Figure 2). Since mammalian phosphorylation of clock proteins have also been observed, it appears that phosphorylation is a highly conserved PTM across kingdoms involved in ...
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Phosphorylation sur tyrosine de la VE-cadhérine en réponse au VEGF : mécanismes moléculaires et implications physiopathologiques
... Tyrosine phosphorylation of the cadherin–catenin complex has been proposed as a mechanism that regulates the stability of cell–cell ...nine tyrosine that represent potential target sites for ...
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Rôle de la phosphorylation sur tyrosine dans la régulation de l'activité de PPARγ
... PPAR2 tyrosine phosphorylation ...two, tyrosine residues out of 18, of which at least 5 might be phosphorylated, were mutated making the possible variations very hard to detect by western blot ...of ...
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Control of Listeria superoxide dismutase by phosphorylation
... FIGURE 1. Regulation of L. monocytogenes MnSOD activity by phosphorylation. A, phosphoproteome analysis of protein extracts from wild-type EGDe strain (WT) and ⌬stp mutant (30). Phosphorylation of the L. ...
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Increased phosphorylation of vimentin in noninfiltrative meningiomas.
... Vimentin is also a well-known substrate for several kinases. Close to 40 different phosphorylated sites have been experimen- tally identified (Uniprot, http://www.uniprot.org, P08670 and references therein) [33–38]. ...
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Rôles et régulation des tyrosine kinases Src dans la survie entérocytaire humaine
... Les tyrosine kinases membres de la famille Src (TKs Src) sont reconnues pour leur participation dans la signalisation intégrines-Fak chez plusieurs types cellulaires. De plus, certaine[r] ...
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Rôle de la proteine tyrosine phosphatase SHP-1 dans la biogenèse du phagolysosome
... 42 start of phagocytosis, we observed that approximately 80% of phagosomes were positive for LAMP-1 in me-3 macrophages (Fig. 4A and B). We next assessed by Western blot the presence of LAMP-1 in purified phagosome ...
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Évaluation de méthodes de phosphorylation, de sulfatation et de cyclisation de l'endothéline-1
... La seconde méthode a privilégié l'usage des groupes protecteurs Trt pour les cystéines en position 1 et 15, et les dérivés cystéines méthoxytriphénylméthyle (Mmt) aux positi[r] ...
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Inhibition du transport des analogues nucléosidiques par l'inhibiteur de tyrosine kinase nilotinib
... La protéine Abl est normalement impliquée dans le remodelage du squelette d’actine, l’adhésion, la motilité [19] et la régulation du cycle cellulaire à travers l’intégration de plusieurs signaux de sources extra et ...
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Identification des sites de phosphorylation basale et dépendante de la PKC sur TRPC6
... Protein kinase C-dependent phosphorylation of transient receptor potential canonical 6 (TRPC6) on serine 448 causes channel inhibition.. Avant-propos:.[r] ...
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Modulation de la protéine de polarité épithéliale Yurt par phosphorylation et oligomérisation
... 1.4.4.3. Implication de Yrt dans la polarité épithéliale Les protéines Yrt, EPB41L5 et EHM2 sont principalement localisées à la membrane latérale des cellules épithéliales de la drosophile (Laprise et al., 2006), de la ...
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Impact de la température corporelle sur la phosphorylation de tau dans le contexte du sommeil
... Tau phosphorylation was negatively correlated with body temperature, with hyperphosphorylation at lower temperatures during ...the phosphorylation of tau and temperature during the rest period than during ...
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Tip60 acetyltransferase activity is controlled by phosphorylation.
... Fig. 2. Serines 86 and 90 are two major sites of Tip60 phosphorylation. A, amino acid 1‐211 region of Tip60 expressed and purified from insect cells was digested with trypsin, and the CIP‐treated and untreated ...
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Régulation de la kinase Ste20 Slik de Drosophila par phosphorylation de la boucle d'activation
... 1.1.4 Conservation de gènes entre la drosophile et les mammifères L’utilisation de la drosophile comme modèle comporte l’avantage majeur d’avoir plusieurs mécanismes développementaux conservés chez l’humain. Les ...
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