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tumor necrosis factor-α

Combined Stimulation with the Tumor Necrosis Factor α and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices.

Combined Stimulation with the Tumor Necrosis Factor α and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices.

... growth factor induces the ERK1/2 phosphorylation but fails to activate expression of late G1 and S phase markers such as cyclin D1 and Cdk1 indicating that hepatocytes are arrested in mid-G1 phase of the cell ...

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Tumor necrosis factor-α blockade in recurrent and disabling chronic sciatica associated with post-operative peridural lumbar fibrosis: results of a double-blind, placebo randomized controlled study

Tumor necrosis factor-α blockade in recurrent and disabling chronic sciatica associated with post-operative peridural lumbar fibrosis: results of a double-blind, placebo randomized controlled study

... cytokine tumor necrosis factor (TNF)-α promotes the production of pro-inflammatory soluble mediators, angiogenic factors and chemokines by various cell types and tissues ...and ...

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en fr Effects of Interleukine-17A (Il-17A) and tumor necrosis factor alpha (TNF-α) on osteoblastic differentiation Effets de l'Interleukine-17A et le facteur de nécrose tumorale alpha (TNF-α) sur la différenciation ostéoblastique

... specifically tumor necrosis factor alpha (TNF-α), results in a synergistic effect which contribute to the chronicity of the bone inflammatory diseases such as rheumatoid arthritis (RA) and ...

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Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells

Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells

... Figure 2. BT environment mediates inhibition of IFN-a production by TLR-activated pDC in vitro and TApDC in vivo through TGF-b1 and TNF-a. (a) Healthy pDCs were pretreated with IL-3 6 TGF-b1 (0.01 ng/mL), TNF-a (0.5 ...

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Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers: a case-control study.

Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers: a case-control study.

... 25. Bibbo C, Goldberg JW: Infectious and healing complications after elective orthopaedic foot and ankle surgery during tumor necrosis factor-alpha inhibition therapy. Foot Ankle Int 2004, ...

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Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.

Tumor necrosis factor is a survival and proliferation factor for human myeloma cells.

... survival factor for malignant plasma ...that tumor necrosis factor α (TNF-α) is also a survival factor for myeloma cell lines, although less potent than ...

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Regulation of Neuroinflammation: What Role for the Tumor Necrosis Factor-Like Weak Inducer of Apoptosis/Fn14 Pathway?

Regulation of Neuroinflammation: What Role for the Tumor Necrosis Factor-Like Weak Inducer of Apoptosis/Fn14 Pathway?

... Anti-TweAK Antibodies improve a Murine Model of Parkinson’s Disease Parkinson’s disease is a neurodegenerative pathology character- ized by movement impairment due to dopaminergic loss in the nigrostriatal pathway. It ...

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Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes.

Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes.

... Discussion Proinflammatory cytokines play an important role in the pathogenesis of joint destruction and osteoporosis in RA. Nevertheless, the mode of activation of these ubiquitous TFs is poorly understood when ...

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Severe skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy.

Severe skin lesions cause patients with inflammatory bowel disease to discontinue anti-tumor necrosis factor therapy.

... Eczematiform and psoriasiform eruptions are, after infections, the most frequent dermatological adverse events in patients receiving anti-TNF-α therapy. 12,13 Their prevalence in patients with IBD is unknown. ...

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Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease

Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease

... according to the values of variables and continues splitting branches in an iterative process that leads to the target value. Each split depends on the value of only one variable x. Suppose that there are M variables: at ...

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Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments.

Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments.

... Davignon et al. Arthritis Research & Therapy 2010, 12:R142 http://arthritis-research.com/content/12/4/R142 Page 2 of 8 reactivated under situations of immunosuppression. Although cases of lymphoproliferative ...

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Antitumour necrosis factor-α therapy for hidradenitis suppurativa: results from a national cohort study between 2000 and 2013

Antitumour necrosis factor-α therapy for hidradenitis suppurativa: results from a national cohort study between 2000 and 2013

... To the editor Hidradenitis suppurativa (HS) is a frequent chronic inflammatory skin disease typically characterized by recurrent painful, deep inflammatory nodules of the axillary, breast, groin and gluteal areas. 1,2 ...

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Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis.

Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis.

... of tumor vasculature that appears normalized as described by Carmeliet and Jain (26, ...that tumor vessel normalization improves tumor perfusion and oxygenation and decreases ...prognostic ...

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Tumor Necrosis Factor-Alpha Antagonist Interferes With the Formation of Granulomatous Multinucleated Giant Cells: New Insights Into Mycobacterium tuberculosis Infection

Tumor Necrosis Factor-Alpha Antagonist Interferes With the Formation of Granulomatous Multinucleated Giant Cells: New Insights Into Mycobacterium tuberculosis Infection

... particularly Tumor Necrosis Factor (TNF)-α is critical in the control of Mtb infections and that anti-TNF-α drugs constitute one of the main risk factors for reactivation of latent Mtb ...

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en fr Tumor necrosis factor receptor-associated factor 4 (TRAF4) is a new phosphoinositide binding protein regulating cell polarity and migration Tumor necrosis factor Receptor-Associated Factor 4 (TRAF4) est une nouvelle protéine interagissant avec les phosphoinositides, impliquée dans la polarité et la migration cellulaire

... ROS act as signaling molecules that mediate growth-related responses such as angiogenesis. As a result, abnormal ROS production is implicated in various diseases including atherosclerosis, cardiovascular problems and ...

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Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation

... transcription factor orthodenticle homeobox 2 (OTX2) that is constitutively expressed in RPE cells, where it regulates a number of essential RPE genes [ 22 ] and TNF-α exposure has been shown to ...

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Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.

Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.

... TNF- α are mediated (7, ...TNF- α is known to antagonize most of TGF- β effects on gene expression ...TNF- α, as well as c-Jun overexpression, prevents TGF-β activation of the α2 type I collagen gene ...

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Natural antisense RNA inhibits the expression of BCMA, a tumour necrosis factor receptor homologue.

Natural antisense RNA inhibits the expression of BCMA, a tumour necrosis factor receptor homologue.

... Results and Discussion BCMA overexpression, like that of all TNFRs described to date, activates the NF-kappaB nuclear factor [21]. To in- vestigate the function of antisense BCMA p12, we overex- pressed BCMA in ...

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Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha

Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha

... cytokine tumor necrosis factor SF2 (referred to as TNF hereinafter), I␬B␣ is phosphor- ylated on two specific serine residues by a large cytoplasmic I␬B kinase (IKK) complex that consists of the ...

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Elevations of tumor necrosis factor-receptor-1 at day 7 and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning

Elevations of tumor necrosis factor-receptor-1 at day 7 and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning

... by tumor necrosis factor alpha (TNF alpha) release in the course of pretransplant conditioning: role of conditioning regimens and prophylactic application of a monoclonal antibody neutraliz- ing ...

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