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transgenic mouse model

Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary Cancer

Multimodal In Vivo Imaging of Tumorigenesis and Response to Chemotherapy in a Transgenic Mouse Model of Mammary Cancer

... The transgenic mouse model of mammary carcinoma caused by expression of the polyoma middle T oncoprotein (PyMT) in the mammary epithelium [ 1 ] mimics the Luminal B type of human breast ...

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Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease

Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease

... in transgenic mouse models of AD obtained by using a fully automated whole-brain analysis without any anatomical a ...APP/PS1 transgenic mouse model of AD ( Sadowski et ...

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Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

Distinguishing core from penumbra by lipid profiles using Mass Spectrometry Imaging in a transgenic mouse model of ischemic stroke

... a transgenic mouse model with an enhanced susceptibility to ischemic stroke, we found a more pronounced discrimination in sodium/potassium ratios between penumbra and healthy ...

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Benfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy

Benfotiamine Treatment Activates the Nrf2/ARE Pathway and is Neuroprotective in a Transgenic Mouse Model of Tauopathy

... mechanism. This is advantageous since it avoids the potential toxicity of Nrf2 activators, which act by alkylation. In summary, our study provides the first evidence that long-term treatment with BFT is neuroprotective ...

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RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model

RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model

... An increased RANKL/OPG ratio has been reported in periodontal tissues under pathological conditions, such as Pd ( Mogi et al., 2004 ). RANKL levels in periodontal fibroblasts are induced either by mechanical forces or ...

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MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid ă pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid ă pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease

... The MT5-MMP cDNA was amplified by PCR from C57Bl6 mouse cerebellum and cloned using protocols previously described for other MMP cDNAs [ 24 – 26 ]. The following primers were used: MT5For ATA TAT GAA TTC GGA TGC ...

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Characterization of plasmacytoid dendritic cells in the CD4C/HIV transgenic mouse model

Characterization of plasmacytoid dendritic cells in the CD4C/HIV transgenic mouse model

... microbial pathogens: development of agonists for Toli-like receptor 9. Curr opin Drug Discovery Devel. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor[r] ...

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Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1

Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1

... of transgenic mice contain- ing hPLA2R1 downstream of the LoxP-NeoR-Stop-LoxP sequence was subsequently performed by PCR on new- born pups ...These transgenic mice were referred as NeoR-hPLA2R1 animals, ...

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Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

... another mouse cohort to further increase the activation of astrocytes by stimulation of the JAK2-STAT3 ...another mouse model of AD ( Ceyzériat et ...

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Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.

... 18 4.2. Reactive astrocytes do not influence molecular hallmarks of AD in 3xTg mice. We show that JAK2-STAT3-dependent reactive astrocytes do not significantly impact Tau and amyloid pathologies. This was observed at ...

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Knowledge Discovery in Hepatitis C Virus Transgenic Mice

Knowledge Discovery in Hepatitis C Virus Transgenic Mice

... 3 Institute for Biological Sciences, Bldg. M-54 NRC, Ottawa, On. K1A0R6 Canada {brandon.smith}@nrc.gc.ca Abstract. For the purpose of gene identification, we propose an approach to gene expression data mining that uses a ...

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Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models

Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models

... a transgenic mouse model, we have previously shown that constitutive active b-catenin is a bona fide adrenal ...distinct transgenic mouse models of Igf2 overexpression in the adrenal ...

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Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy

Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy

... of model-based dosimetry may have to be reconsidered: If cumulated activities can be obtained for a given animal, then on principle the absorbed dose should be determined for the animal itself rather than for a ...

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Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimer’s disease

Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimer’s disease

... in transgenic mice (3 out of 20; 15%) compared to WT mice (12 out of 27; 44%; Table ...in transgenic mice (7 out of 27; 26%) was not significantly different compared to WT mice (4 out of 19, 20%; z-test, ...

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Effect of osteogenesis imperfecta on orthodontic tooth movement in a mouse model

Effect of osteogenesis imperfecta on orthodontic tooth movement in a mouse model

... Discussion This is the first study of orthodontic tooth movement on an osteogenesis imperfecta animal model. Bone cell function and the remodeling mechanisms which normally maintain bone homeostasis are altered ...

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A switched dynamic model for pointing tasks with a computer mouse

A switched dynamic model for pointing tasks with a computer mouse

... jerk model proposed by Hogan in [ 21 ], which claims that the ballistic movement is performed in such a way that the total jerk cost along the trajectory is ...jerk model is the implied symmetry of the ...

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Regulating transgenic soybean production in Argentina

Regulating transgenic soybean production in Argentina

... from transgenic soybean expan- sion, policy action is needed to promote a socially optimal output ...regulating transgenic soybean in ...of transgenic soybean production, and then successively ...

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Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

... our model emphasizes the importance of Tau pathology in such defects, the comparable sequence of septo-hippocampic defect seen in THY-Tau22 mice and AD patients indicates that this model is an invaluable ...

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New role of P2X7 receptor in an Alzheimer's disease mouse model

New role of P2X7 receptor in an Alzheimer's disease mouse model

... β mouse model, sustained ATP release may induce the engagement of different purinergic receptors; thus, P2X7R de ficiency might not alter microglial activation ...

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AMPK: Lessons from transgenic and knockout animals.

AMPK: Lessons from transgenic and knockout animals.

... muscle-specific transgenic mice expressing an inactive AMPKα2D157A mutant (AMPKα2i) have significantly lower exercise tolerance (43) suggesting a direct role of AMPK in the adaptation to ...using transgenic ...

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