transforming growth factor-β
Transforming Growth Factor-β Signaling Plays a Pivotal Role in the Interplay Between Osteosarcoma Cells and Their Microenvironment
... secrete growth factors, such as transforming growth factor- β (TGF-β), which favors the development of primary tumors and dissemination of metastases by constituting a permissive ...
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Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia
... the transforming growth factor β (TGFβ) signaling pathway in DBA ...TGF β target genes, such as TGFBI, BAMBI, COL3A1 and SERPINE1 was significantly increased in the DBA ...TGF β ...
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Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-β type II receptor (sTGFβRII) gene transfer
... human corneal fibroblasts, and (ii) whether the nanoparticle-mediated soluble extracellular domain of the transforming growth factor–β type II receptor (sTGFβRII) gene therapy could be [r] ...
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Opposite Effects of Transforming Growth Factor-β Activation and Rho-Associated Kinase Inhibition on Human Trophoblast Migration in a Reconstituted Placental-Endometrial Coculture System
... Production of trophoblast cells by the villi and migration of these EVCTs away from the villi, onto the fi- broblast layer, were followed by phase-contrast time-lapse analysis (Fig. Impo[r] ...
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Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells
... Furthermore, IF stainings showed that IRF-7 protein, local- ized in the cytoplasm of resting pDC, was upregulated and translocated in the nucleus after 3-hr stimulation with Flu virus (Fig. 3d). This process was ...
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Transforming Growth Factor-β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma
... Fig. 3. Effects of long-term TGF-β exposure on mesenchymal-like HCC cells. (A) Western blot analysis of pSmad2 and Snail after serum starvation and stimulation with 2.5 ng/mL TGF-β1 (left panel), and after serum ...
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Transforming growth factor-beta and fibrosis.
... Abstract Transforming growth factor-β (TGF-β), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and ...
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Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
... 1.3. Targeted Therapies Although significant progress in understanding the molecular basis of CCA pathogenesis has been achieved, there is no approved molecular targeted therapy that significantly improves patient ...
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Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation.
... TGF- β regulatory effects on gene expression, such as the modulation, either negative or positive, of interstitial collagenase (MMP-1), plasminogen activator inhibitor-1 (PAI-1), or transin (rat MMP-3) ...TGF- ...
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Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
... effects on both Gli2 and Gli1 expression (Fig. 2B). Under the same conditions, Ptch-1, a classic Shh target, was strongly induced by Shh, not by TGF-β (upper panel), suggesting that Ptch-1 modulation is not solely ...
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en fr Role of the small heat shock protein alphaB-crystallin in pulmonary fibrosis and its implication in the signaling pathway of the Transforming Growth Factor béta1 Rôle de la petite protéine de choc thermique alphaB crystallin dans la fibrogénèse pulmonaire et son implication dans la voie de signalisation du transforming growth factor - béta1
... la β-galactosidase capable d’hydrolyser le lactose et le galactose. La β- galactosidase peut donc hydrolyser le X-Gal (un galactoside) et former ainsi par oxydation un composé bleu, qui précipite sur le ...
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Platelet transforming growth factor-β1 induces liver sinusoidal endothelial cells to secrete interleukin-6
... Cells 2020, 9, x 14 of 22 Figure 5. Transforming growth factor β1 is a strong candidate to activated platelet releasate soluble factor. A: LSEC titration with recombinant human TGF-β1 induced ...
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Glycoproteomic analysis of two mouse mammary cell lines during transforming growth factor (TGF)-Beta induced epithelial to mesenchymal transition
... Two-dimensional gel electrophoresis studies: BRI-JM01 cells To identify EMT-related changes in protein expression in BRI-JM01 cells, our preliminary experiments utilized a tra- ditional proteomics workflow: two ...
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Transforming growth factor-beta: a key mediator of fibrosis.
... transduction pathways [5]. The LTGF-β molecules consist of 390 to 414 amino acids with three specialized regions: an amino-terminal hydrophobic signal peptide region, the latent-associated peptide (LAP) region of ...
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TGF- β Polymorphisms Are a Risk Factor for Chagas Disease
... TGF- β, and IL-18) and others with cardio- myopathy development (TNF, IL-1, BAT1, MCP-1, LT- α, IL-12, and IL-10) ...TGF- β with Chagas disease since the late ’90s, and our contribution was recently ...
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Placental growth hormone (GH), GH-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: Correlations with fetal growth
... GH/insulin-like growth factor I (IGF-I) axis, fetal growth, and maternal glycemic ...fetal growth, and ...fetal growth and other endocrine ...
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Characterizing and engineering antibodies against the epidermal growth factor receptor
... 1.3 EGFR in cancer EGFR was the first receptor to be directly linked to human cancer (51), and because EGFR activation often leads to cellular growth, its signaling can provide tumor cells with substantial ...
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Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
... collateral growth during ischemia, inflammation, wound healing and ...collateral growth in Pgt -/- mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing ...
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Vascular endothelial growth factor (VEGF) in endometriosis.
... permeability factor, is a heparin-binding glycoprotein with potent angiogenic, endothel- ial cell-specific mitogenic and vascular permeability ...angiogenic factor in many physiological and pathological ...
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Controlled Delivery of Transforming Growth Factor β1 by Self-Assembling Peptide Hydrogels Induces Chondrogenesis of Bone Marrow Stromal Cells and Modulates Smad2/3 Signaling
... 8. Coffey, R.J., Jr., Russell, W.E., and Barnard, J.A. Pharmaco- kinetics of TGF beta with emphasis on effects in liver and gut. Ann N Y Acad Sci 593, 285, 1990. 9. Mi, Z., Ghivizzani, S.C., Lechman, E., Glorioso, J.C., ...
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