Toll-like receptor-2
Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype.
... Manuscript word count: 3130 words Abstract word count: 249 words ABSTRACT Background: Integrin !3 (ITGB3) and Toll-like receptor 2 (TLR2) are candidate genes for asthma and sensitization to ...
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L’œstrogène : un rôle potentiel dans la modulation de l’activation pro-inflammatoire des cellules endothéliales vasculaires par la voie du Toll-Like Receptor 2
... mRNA and protein expression were detected in unstimulated EOMAs, mRNA expression was the only one modulated by the LPS. Nevertheless, TLR2 expression in ECs is still under investigation, and numerous studies have ...
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Substance P primes lipoteichoic acid- and Pam3CysSerLys4- mediated activation of human mast cells by up-regulating Toll-like receptor 2
... type 2 (HSV-2) had signifi- cantly enhanced levels of HSV-2 in the genital tract and central nervous system following infection compared with wild-type ...
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Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles.
... dependent signaling: stably transfected CHO cells expressing human TLR2 and/or TLR4 on 18. their cell surface and a reporter gene allowing detecting ligand-induced TLR activati[r] ...
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Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway
... Santa Cruz Biotechnology. IKK α, IKK β, and TLR4 siRNAs were from Dharmacon (CO, USA). Trans- fection of siRNA was carried out using Lipofectamine RNAiMAX (Thermo Fisher Scienti fic) at a final con- centration of 25 or 50 ...
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Cross Talk between Inhibitory Immunoreceptor Tyrosine-Based Activation Motif-Signaling and Toll-Like Receptor Pathways in Macrophages and Dendritic Cells
... interleukin-1 receptor-associated kinase 1/4 (IRAK1/4), tumor necrosis factor receptor-associated factors 3 and 6 (TRAF3/6), and interferon-regulatory factor 7 (IRF7), and that results in the type I IFN ...
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Mycobacterial phosphatidyl inositol mannosides negatively regulate host toll-like receptor 4, MYD88-dependent proinflammatory cytokines and trif-dependent co-stimulatory molecules expression.
... anosoma or Plasmodium. Although some GPI anchors have been reported to stimulate host inflammatory responses, GPI- anchored mucin from Trypanosoma cruzi membrane abro- gated monocyte TNF and IL-12 expression (55), and ...
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Toll-like receptor expression and function differ between splenic marginal zone B cell lymphoma and splenic diffuse red pulp B cell lymphoma
... Recently, evidence of BCR/TLR interactions has been demonstrated in Chronic Lymphocytic Leukemia (CLL), since simultaneous engagement of BCR/TLR leads to different responses in CLL depending on the mutational status of ...
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en fr Contribution of Death Receptors and Toll-Like Receptors to human hematopoiesis CONTRIBUTION DES RÉCEPTEURS À DOMAINE DE MORT ET DES RÉCEPTEURS DE LA FAMILLE TOLL À L'HÉMATOPOÏÈSE HUMAINE
... to the experimental models used in our study and that by Ursini- Siegel et al. (21), the possibility that PC attrition operates through different mechanisms depending on their maturational stage is worthwhile ...
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Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
... France, 2 CNRS, UMR7258, Marseille, France, 3 Institut Paoli-Calmettes, Marseille, France, 4 Aix-Marseille Université, UM105, Marseille, France, 5 Institute of Molecular Genetics, Czech Academy of Sciences, ...
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Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies
... microbes, Toll-like receptors (TLRs) belong presently among the best-studied receptors of verte- brate ...of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus ...
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Étude du polymorphisme du récepteur Toll-like 4 dans le syndrome des anti-phospholipides
... 16 2. Récepteurs Toll-Like 1) Généralités sur l’immunité innée L’immunité repose sur les réponses immunitaires innées et ...« toll-like receptors » (TLR), les « nucleotide-binding ...
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Étude moléculaire du TNF-Related Apoptosis Induced Ligand (TRAIL) et de l’activation du Toll-Like Receptor 7 (TLR7) dans les cellules dendritiques plasmacytoïdes lors de la réponse antivirale
... 2014). La chimiokine interagit par son corps globulaire avec le côté N-terminal du récepteur appelé site de reconnaissance aux chimiokines 1 (chemokine recognition site 1 = CRS1) ce qui oriente le N-terminal de la ...
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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
... Our data confirm that the positive allosteric modulator of mGlu 5 , DFB is devoid of agonist activity on the wild-type receptor (it is not able to activate the full length receptor by itself) (31). We ...
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Molecular Basis of Complement C1q Collagen-Like Region Interaction with the Immunoglobulin-Like Receptor LAIR-1
... receptors. By deleting the N-terminal portion of each C1q collagen chain until the hinge region, we managed to produce one isolated heterotrimeric C1q collagen stem (called C1qstem_nc2). We showed that the affinity ...
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Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)
... Additional file 1: Table S1. Summary of sampled specimens and identification of haplotypes. Table S2. Primer description. Table S3. Residues binding to LPS in TLR4 based on knowledge of 3D- crystalography in human ...
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Dysregulated Responsiveness of Circulating Dendritic Cells to Toll-Like Receptors in ANCA-Associated Vasculitis
... patients as compared to HC (*p < 0.05) and a similar trend in MPA, suggestive of increased CD8 + T cell activation in AAV. DiscUssiOn Although ANCA play a central role in vascular lesions and inflammation during AAV, ...
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Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: reply.
... In a recent issue of the Journal of Thrombosis and Hae- mostasis, we published a study demonstrating that phos- phorothioate (PS)-modified CpG oligodeoxynucleotides (PS-CpG ODNs) types A, B and C activate platelets via ...
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Pascal-like triangles: base 2 and beyond
... A 2 (2 ` + r) = 2 · 3 `−1 + A 2 (2 `−1 + r) + A 2 ...If 2 ` −1 < r < 2 ` , then A 2 (2 ` +r) = 4 ·3 ` −2·3 ` −1 −A 2 (2 ` ...
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Insights into the European rabbit (Oryctolagus cuniculus) innate immune system: genetic diversity of the toll-like receptor 3 (TLR3) in wild populations and domestic breeds.
... Regarding the location of the amino acid changes, most (11) are in the LRR molecules and the remaining (3) are distributed across the transmembrane and TIR domains (Figure 2). The higher variation in the LRRs is ...
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