Toll-like receptor
Caractérisation des propriétés anti-infectieuses de la flagelline, agoniste du Toll-like receptor 5
... IL-22 receptor is not expressed by haematopoietic cells ...molecules like type C lectin RegIII or calgranulin S100A9 (11), protective mucin production (12) and intestinal wound healing (13, ...binds ...
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en fr Functional study of toll-like receptor 9 and neutrophils in inflammation : involvement in the development of rheumatoid arthritis and experimental arthritis Etude fonctionnelle du « Toll-like receptor 9 » et des neutrophiles au cours de l’inflammation : implication dans le développement de la polyarthrite rhumatoïde et d’un modèle expérimental
... 35 parodontites sont causées par Porphyromonas gingivalis, la seule bactérie connue à ce jour capable d’exprimer l’enzyme PADI. Cette protéine produite par P. gingivalis peut citrulliner le fibrinogène humain, protéine ...
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Toll-like receptor 4 knockout mice are protected against endoplasmic reticulum stress induced by a high-fat diet.
... whether toll-like receptor 4 (TLR4) is implicated in the development of endoplasmic reticulum stress (ER stress) observed after a high-fat diet (HFD) in liver, skeletal muscle and adipose ...
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Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype.
... Manuscript word count: 3130 words Abstract word count: 249 words ABSTRACT Background: Integrin !3 (ITGB3) and Toll-like receptor 2 (TLR2) are candidate genes for asthma and sensitization to mold ...
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Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies
... microbes, Toll-like receptors (TLRs) belong presently among the best-studied receptors of verte- brate ...of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus ...
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Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
... ☯ These authors contributed equally to this work. * ruzena.stranska@kuleuven.be (RS); ivan.hirsch@inserm.fr (IH) Abstract Crosslinking of regulatory immunoreceptors (RR), such as BDCA-2 (CD303) or ILT7 (CD85g), of ...
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Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models
... acetylcholine receptor (AChR) at the neuromuscular ...other toll-like receptor (TLR) agonists known to be involved in GC development and that are overexpressed in MG ...
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The Toll-Like Receptor Agonist Imiquimod Is Active against Prions
... diseases like warts on the skin of the genital and anal areas [18], and is also used to treat actinic keratoses, a skin condition of the face and scalp, and superficial basal cell carcinoma a type of skin cancer ...
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<em>Bradyrhizobium</em> Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex
... the receptor complex made up of toll-like receptor 4 (TLR4) and myeloid differentiation protein-2 (MD-2) on the plasma membrane of immune cells thus activating downstream signaling pathways ...
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Insights into the European rabbit (Oryctolagus cuniculus) innate immune system: genetic diversity of the toll-like receptor 3 (TLR3) in wild populations and domestic breeds.
... this receptor has been associated with higher susceptibility and mortality in infections by cyto- megalovirus (CMV) and herpes simplex virus (HSV) in mice and humans ...ruses, like West Nile Virus (WNV), ...
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Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response.
... the fatty acids esterifying the different sites was investigated by mass spectrometry using MALDI-Tof-MS analysis of the acetolysis reaction products of the native tetra-acyl forms of th[r] ...
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Mycobacterial phosphatidyl inositol mannosides negatively regulate host toll-like receptor 4, MYD88-dependent proinflammatory cytokines and trif-dependent co-stimulatory molecules expression.
... We showed recently that mycobacterial LM have a dual potential for pro-inflammatory and anti-inflammatory effects (11), tri- and tetra-acylated LM fractions exerting stimulatory effects [r] ...
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Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7
... endosomal Toll-like receptors (TLR) or cytosolic receptors including retinoic acid-inducible gene I (RIG-I), melanoma differentiation- associated gene 5 (MDA5) and activation of the cGAS – STING ...TLRs ...
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Étude moléculaire du TNF-Related Apoptosis Induced Ligand (TRAIL) et de l’activation du Toll-Like Receptor 7 (TLR7) dans les cellules dendritiques plasmacytoïdes lors de la réponse antivirale
... Depuis que TRAIL est connu pour induire la mort spécifique des cellules cancéreuses et non des cellules normales (à l’inverse de Fas/FasL), les récepteurs de TRAIL et les ligands de TRAIL sont des cibles intéressantes ...
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Substance P primes lipoteichoic acid- and Pam3CysSerLys4- mediated activation of human mast cells by up-regulating Toll-like receptor 2
... Senior author: Marianna Kulka Summary Substance P (SP) is a neuropeptide with neuroimmunoregulatory activity that may play a role in susceptibility to infection. Human mast cells, which are important in innate immune ...
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Cross Talk between Inhibitory Immunoreceptor Tyrosine-Based Activation Motif-Signaling and Toll-Like Receptor Pathways in Macrophages and Dendritic Cells
... duce IL-12 and cross-present antigens for CD8 class I-restricted cytotoxic T lymphocytes ( 26 , 27 ). cDCs detect invading microbes with the cell surface-expressed TLR1 and TLR2, which recognize peptidoglycan and ...
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Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway
... PTX3 plays a major non-redundant role in the humoral innate immunity during complement activation and patho- gen recognition, in flammatory responses, and tissue repair [ 13 , 14 ]. In contrast, its function in tumor ...
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Toll-like receptor expression and function differ between splenic marginal zone B cell lymphoma and splenic diffuse red pulp B cell lymphoma
... Splenic diffuse red pulp lymphoma with villous lymphocytes (SDRPL) is close to but distinct from SMZL, justifying here the comparison of TLR patterns and functionality in both entities[r] ...
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Signatures of positive selection in Toll-like receptor (TLR) genes in mammals.
... The TLR4 forms a dimer with MD-2. The LPS interacts with a large hydrophobic pocket in MD-2 and directly bridges m-shaped receptor dimer composed of two copies arranged symmetrically [23]. Nineteen of the twenty ...
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Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
... mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression of a variety of immune-response genes, including inflammatory ...
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