Toll-like receptor 7
Étude moléculaire du TNF-Related Apoptosis Induced Ligand (TRAIL) et de l’activation du Toll-Like Receptor 7 (TLR7) dans les cellules dendritiques plasmacytoïdes lors de la réponse antivirale
... 6, 7, 8, 10 et 14 sont très efficaces à induire des protéines dépendantes de l’IFN possédant des répétitions tétratricopeptides de type 1 (IFIT1), mais aussi par les cytokines telles que CXCL10, CXCL11, ISG15 et ...
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Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7
... Progress toward a pharmacophore for TLR7 inhibition? Pure biochemical data of the type presented here cannot unambiguously determine the number and structure of ef- fective binding sites. However, we have added an ...
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The Toll-Like Receptor Agonist Imiquimod Is Active against Prions
... diseases like warts on the skin of the genital and anal areas [18], and is also used to treat actinic keratoses, a skin condition of the face and scalp, and superficial basal cell carcinoma a type of skin cancer ...
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Recognition of hepatitis C virus RNA by toll like receptors 7 and 8 : implications for the initiation of innate immune response
... 34 Abstract The hepatitis C virus (HCV) is a positive single-stranded RNA (ssRNA) virus that replicates in the liver and has infected 200 million people worldwide. Recognition of HCV-associated molecular patterns is ...
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Cross Talk between Inhibitory Immunoreceptor Tyrosine-Based Activation Motif-Signaling and Toll-Like Receptor Pathways in Macrophages and Dendritic Cells
... duce IL-12 and cross-present antigens for CD8 class I-restricted cytotoxic T lymphocytes ( 26 , 27 ). cDCs detect invading microbes with the cell surface-expressed TLR1 and TLR2, which recognize peptidoglycan and ...
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Cancer cell-derived long pentraxin 3 (PTX3) promotes melanoma migration through a toll-like receptor 4 (TLR4)/NF-κB signaling pathway
... PTX3 plays a major non-redundant role in the humoral innate immunity during complement activation and patho- gen recognition, in flammatory responses, and tissue repair [ 13 , 14 ]. In contrast, its function in tumor ...
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Mycobacterial phosphatidyl inositol mannosides negatively regulate host toll-like receptor 4, MYD88-dependent proinflammatory cytokines and trif-dependent co-stimulatory molecules expression.
... 3-bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys- (S)-Ser-Lys 4 -OH) tri-hydrochloride, EMC Microcollections, Tuebingen, Germany), 30 ng/ml MALP2 (S-(2,3-bisacy- loxypropyl)-cysteine-GNNDESNISFKEK (Alexis Biochemi- ...
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Substance P primes lipoteichoic acid- and Pam3CysSerLys4- mediated activation of human mast cells by up-regulating Toll-like receptor 2
... epsilon receptor I (FceRI) on the mast cell surface are cross-linked by specific antigen, triggering mast cell degranulation and de novo synthesis of arachidonic metabolites, cytokines and ...
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Toll-like receptor expression and function differ between splenic marginal zone B cell lymphoma and splenic diffuse red pulp B cell lymphoma
... Splenic diffuse red pulp lymphoma with villous lymphocytes (SDRPL) is close to but distinct from SMZL, justifying here the comparison of TLR patterns and functionality in both entities[r] ...
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Caractérisation des propriétés anti-infectieuses de la flagelline, agoniste du Toll-like receptor 5
... IL-22 receptor is not expressed by haematopoietic cells ...molecules like type C lectin RegIII or calgranulin S100A9 (11), protective mucin production (12) and intestinal wound healing (13, ...binds ...
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Importance of melastatin-like transient receptor potential 7 (TRPM7) and cations (Mg2+, Ca2+) in human osteoblast-like cell proliferation
... In order to determine the influence of low extracellular levels of Ca 2+ and Mg 2+ on the acti- vation of channels for the maintenance of cellular ion homeostasis, we performed intracellular Ca 2+ and Mg 2+ measurements ...
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Étude du polymorphisme du récepteur Toll-like 4 dans le syndrome des anti-phospholipides
... même, 7 récidives thrombotiques sous traitement anticoagulant, soit 9,6% des patients atteints de SAPL ont été colligées contre 15% dans la cohorte Europhospholipid ...
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en fr Contribution of Death Receptors and Toll-Like Receptors to human hematopoiesis CONTRIBUTION DES RÉCEPTEURS À DOMAINE DE MORT ET DES RÉCEPTEURS DE LA FAMILLE TOLL À L'HÉMATOPOÏÈSE HUMAINE
... to the experimental models used in our study and that by Ursini- Siegel et al. (21), the possibility that PC attrition operates through different mechanisms depending on their maturational stage is worthwhile ...
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Insights into the European rabbit (Oryctolagus cuniculus) innate immune system: genetic diversity of the toll-like receptor 3 (TLR3) in wild populations and domestic breeds.
... this receptor has been associated with higher susceptibility and mortality in infections by cyto- megalovirus (CMV) and herpes simplex virus (HSV) in mice and humans ...ruses, like West Nile Virus (WNV), ...
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Molecular Basis of Complement C1q Collagen-Like Region Interaction with the Immunoglobulin-Like Receptor LAIR-1
... receptors. By deleting the N-terminal portion of each C1q collagen chain until the hinge region, we managed to produce one isolated heterotrimeric C1q collagen stem (called C1qstem_nc2). We showed that the affinity ...
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Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)
... the Toll/Interleukin-1 Receptor (TIR) domain responsible for TLR signaling ...encing receptor ability to bind pathogens [14,36,39], and may even lead to the evolution of species-specific ligand ...
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Dysregulated Responsiveness of Circulating Dendritic Cells to Toll-Like Receptors in ANCA-Associated Vasculitis
... Our study also indicates that GPA and MPA exhibit some sub- tle difference regarding the function of DC and the frequencies of T cells. Both GPA and MPA are associated with an important decrease in circulating cDCs and ...
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<em>Bradyrhizobium</em> Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex
... way stressing this difference. Furthermore, we also showed that Bradyrhizobium lipid A acts exclusively through TLR4 and do not activate TLR2 at all, in accordance with data from other lipid A strains ( 59 ). These ...
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Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
... Republic, 7 AB Science, Paris, France, 8 Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic, 9 Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS ...
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Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response.
... Macrophage Stimulation by PIM 2 and PIM 6 —Unfraction- ated PIM have been shown to stimulate the murine RAW 264.7 monocytic cell line to produce TNF- ␣ (15), and we asked whether purified PIM 2 and PIM 6 were equally ...
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