TLR: Toll-like receptor
Signatures of positive selection in Toll-like receptor (TLR) genes in mammals.
... The high number of PSC observed in the non-viral TLR4 is in line with results previously reported in primates and birds [39,40]. TLR8 and TLR4 recognize very different ligands. For PAMPs recognition, TLR8 forms a ...
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Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies
... the Toll-like receptors (TLR) have been shown to be particularly important (Akira et ...of TLR types varies substantially among vertebrate lineages (Janssens and Beyaert 2003; Akira et ...
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Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response.
... different TLR, were used to investigate the TLR dependence of the PIM 2 and PIM 6 ...the TLR-mediated signals (31), including TLR2 as shown here for the TLR2 agonist BLP and for the best of the ...
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Toll-like receptor 4 knockout mice are protected against endoplasmic reticulum stress induced by a high-fat diet.
... insulin receptor substrate (IRS) ...membrane receptor and activating a downstream cascade of events that would crosstalk with insulin ...membrane receptor, namely the toll-like ...
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Reconnaissance moléculaire du virus Epstein-Barr par les "Toll-like receptors"
... cells like monocytes and dendritic cells play a key role in host defense to elicit cellular and humoral ...second TLR may contribute with TLR9 to the induction of inflammatory ...another receptor in ...
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en fr Functional study of toll-like receptor 9 and neutrophils in inflammation : involvement in the development of rheumatoid arthritis and experimental arthritis Etude fonctionnelle du « Toll-like receptor 9 » et des neutrophiles au cours de l’inflammation : implication dans le développement de la polyarthrite rhumatoïde et d’un modèle expérimental
... des TLR (2 et 4) ou le C5a (molécule du complément activé) pourraient moduler le recrutement des neutrophiles dans les tissus inflammatoires en modifiant l’expression de récepteurs aux ...des TLR, ...
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Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
... ☯ These authors contributed equally to this work. * ruzena.stranska@kuleuven.be (RS); ivan.hirsch@inserm.fr (IH) Abstract Crosslinking of regulatory immunoreceptors (RR), such as BDCA-2 (CD303) or ILT7 (CD85g), of ...
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Activation of mast cells by double-stranded RNA: evidence for activation through toll-like receptor 3 (TLR3)
... expressed TLR-3 as well as all other known TLRs except ...addition, TLR-3 signaling with polyI:C was uniquely capable of inducing the production of type I IFNs and did not result in the production of other ...
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Toll-like receptor expression and function differ between splenic marginal zone B cell lymphoma and splenic diffuse red pulp B cell lymphoma
... Among the splenic B cell lymphomas, the splenic diffuse red pulp lymphoma with villous lymphocytes (SDRPL) has been identified as an entity close to but distinct from SMZL [13]. Indeed, each entity presents different ...
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Insights into the European rabbit (Oryctolagus cuniculus) innate immune system: genetic diversity of the toll-like receptor 3 (TLR3) in wild populations and domestic breeds.
... Background: Toll-like receptors (TLRs) belong to the innate immune system and are a major class of pattern recognition receptors representing the first line of the innate immune ...The TLR molecule ...
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La régulation de l’hepcidine à travers les récepteurs Toll-like dans les macrophages
... by toll-like receptor 4 ...identify TLR ligands able to induce hepcidin in macrophages and to determine the requirement for TLRs in hepcidin expression and the development of ...by TLR ...
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Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7
... endosomal Toll-like receptors (TLR) or cytosolic receptors including retinoic acid-inducible gene I (RIG-I), melanoma differentiation- associated gene 5 (MDA5) and activation of the cGAS – STING ...
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Substance P primes lipoteichoic acid- and Pam3CysSerLys4- mediated activation of human mast cells by up-regulating Toll-like receptor 2
... epsilon receptor I (FceRI) on the mast cell surface are cross-linked by specific antigen, triggering mast cell degranulation and de novo synthesis of arachidonic metabolites, cytokines and ...of TLR on ...
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Cross Talk between Inhibitory Immunoreceptor Tyrosine-Based Activation Motif-Signaling and Toll-Like Receptor Pathways in Macrophages and Dendritic Cells
... includes TLR adaptor MyD88, interleukin-1 receptor-associated kinase 1/4 (IRAK1/4), tumor necrosis factor receptor-associated factors 3 and 6 (TRAF3/6), and interferon-regulatory factor 7 (IRF7), and ...
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Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models
... of TLR agonists in autoimmune experimental models has been largely studied for their adjuvant effect or their direct effect in inducing or exacerbating these ...of TLR agonists in the development of ectopic ...
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Étude moléculaire du TNF-Related Apoptosis Induced Ligand (TRAIL) et de l’activation du Toll-Like Receptor 7 (TLR7) dans les cellules dendritiques plasmacytoïdes lors de la réponse antivirale
... son TLR induit la dimérisation et la translocation d’IRF5 dans le ...de TLR et dans l’induction des gènes des cytokines pro-inflammatoires (TNF, IL-6 et IL-12p40) (Takaoka et ...des TLR, IRF5 se fixe ...
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Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease
... endogenous TLR ligands, for instance heat schock proteins, might contribute significantly to sterile inflammation, and appropriate antagonists may represent a new class of therapeutic agents for such diseases ...
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Le récepteur Toll-like 8 - Un TLR pas comme les autres
... récepteurs Toll dans l’immunité innée a été décrit pour la pre- mière fois chez la ...Initialement, Toll a été identifié comme un récepteur transmembranaire nécessaire à l’établissement de la pola- rité ...
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Caractérisation des propriétés anti-infectieuses de la flagelline, agoniste du Toll-like receptor 5
... Nous avons observé que le pneumocoque fluorescent se localise au niveau des épithéliums alvéolaires et bronchiques. L’activation de l’épithélium est décrite comme étant essentielle dans d’autres modèles de protections ...
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Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)
... encoding Toll-like receptor 4 (Tlr4) and 7 (Tlr7), two of the key bacterial- and viral- sensing receptors of innate immunity, across 23 species within the subfamily ...both Tlr genes is ...
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