Tissue factor pathway inhibitor 2
Expression and methylation status of tissue factor pathway inhibitor-2 gene in non-small-cell lung cancer
... potent inhibitor of plasmin within the ECM is tissue factor pathway inhibitor-2 (TFPI-2), also called matrix- associated serine protease inhibitor ...
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Genetic variation 25.1 Mb upstream of tissue factor pathway inhibitor is associated with TFPI plasma levels and venous thromboembolism
... were reported as Bayes Factors, with log 10 (Bayes Factors) between 1 and 10 defining “strong evidence” for linkage [35]. Using SOLAR, the chromosome 2q region was the highest peak genome-wide, and the LOD score of the ...
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CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.
... this tissue ( ...JAK/STAT pathway, and consequently through increasing the expression of SOCS2, which is a known inhibitor of the insulin receptor, and increasing the activity of Stat5 signaling up ...
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Longer procoagulant phospholipid-dependent clotting time, lower endogenous thrombin potential and higher tissue factor pathway inhibitor concentrations are associated with increased VTE occurrence in patients with newly diagnosed multiple myeloma: results of the prospective ROADMAP-MM-CAT study
... thromboembolism (VTE) 1 . The incidence of VTE in MM patients is estimated at 8–22 per 1000 person years and approximately 10% of newly diagnosed MM patients (NDMM) will develop VTE 2 – 4 .The risk of VTE is ...
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Role of the early secretory pathway in SARS-CoV-2 infection
... transcription factor that promotes tran- scription of genes encoding proteins involved in entry into the ER, folding, glycosylation, ERAD, lipid biogenesis, and vesicular trafficking ( Huh et ...
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Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway.
... RESULTS Specific inhibition of RhoA, Rac1 and Cdc42 expression by siRNA. The RhoA-targeting siRNA designed in a previous work (Deroanne et al., 2003) served as a guideline to define the siRNA target sequences for Rac1 ...
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Targeting the AMPK pathway for the treatment of Type 2 diabetes.
... Benoît Viollet, Louise Lantier, Jocelyne Devin-Leclerc, Sophie Hébrard, Chloé Amouyal, et al... Tar- geting the AMPK pathway for the treatment of Type 2 diabetes...[r] ...
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Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways
... liver tissue are supported by an integrative analysis of ENCODE cell lines, which showed that active chromatin states are depleted of regulatory motif instances relative to all regions bound by a given TF ( Ernst ...
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Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells
... Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells.. Lara Bellini, Thomas Strub, Nadia Habel, Charlotte Pandiani, Sandrine Marchetti, Arnaud Mart[r] ...
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The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis
... angiogenic cells, growth factor and anti-oxidative gene profiles might be altered in type 2 diabetes with and without diabetic foot syndrome. J Diabetes Investig 5, 99- 107 34. Barbagallo, I., Vanella, A., ...
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Regulation of Tissue Factor by Epithelial-to-Mesenchymal Transitions: Impacts for the metastatic progression.
... of Tissue Factor ( TF ), a major cellular factor of coagulation, by aggressive epithelial tumor cells has been reported and the activation of the coagulation system is a long-described correlate of ...
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Regulation of Tissue Factor by Epithelial-to-Mesenchymal Transitions: Impacts for the metastatic progression
... Our project aims at examining the contribution of vimentin as a molecular EMT actor potentially involved in EMT-modulated TF expression, and to further explore the impact of these regulations on the metastatic spread. ...
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Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice
... Complex 2 (PRC2), and particularly its catalytic subunit Enhancer of Zeste Homolog 2 (EZH2), inhibiting the trimethylation of the lysine 27 on histone H3 (H3K27me3) ...
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Regulation of Tissue Factor by Epithelial-to-Mesenchymal Transitions: Impacts for the metastatic progression.
... Our project aims at examining the contribution of vimentin as a molecular EMT actor potentially involved in EMT-modulated TF expression, and to further explore the impact of these regulations on the metastatic spread. ...
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Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction
... engineering (26). Dose tunability and delivery of these potent biologics in a manner that can be adapted for clinical application is critical to the success of this strategy. In this study, we have demonstrated that the ...
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Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs
... Our understanding of how DNA methylation impacts gene expression has greatly expanded from the early paradigm that methylation of CpG islands in gene pro- moters inhibits gene expression. It is both novel and surprising ...
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Quantitative characterization of tissue microstructure in concentrated cell pellet biophantoms based on the structure factor model
... structure factor model (SFM), which has been used for ultrasonic characterization of blood [17], ...on tissue-mimicking phantoms ...structure factor is approximately equal to ...structure ...
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CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Étude de l’expression de « Bcl-2 modifying factor » (Bmf) et son implication dans la néphropathie diabétique
... intrinsic pathway of ...Version 2 Array) was used, since a Bmf probeset was not present in these ...type 2 diabetes as compared to non-diabetic patients (kidney ...
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Regulation of Connective Tissue Growth Factor and Cardiac Fibrosis by an SRF/MicroRNA-133a Axis
... Fig 2. Effects of cardiac-specific overexpression of SRF on heart dilation and cardiomyocyte architecture. (A) Western blot analysis of SRF protein (10 μg of total protein per lane). The blot was also probed for ...
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