thiamine triphosphate
Adenylate kinase 1 knockout mice have normal thiamine triphosphate levels
... Abstract Thiamine triphosphate (ThTP) is found at low concentrations in most animal tissues and it may act as a phosphate donor for the phosphorylation of proteins, suggesting a potential role in cell ...A ...
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An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate
... coli, thiamine triphosphate (ThTP), a putative signaling molecule, transiently accumulates in response to amino acid ...free thiamine diphosphate (ThDP) and P i , the reaction being energized by the ...
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Thiamine Diphosphate Adenylyl Transferase from E. Coli: Functional Characterization of the Enzyme Synthesizing Adenosine Thiamine Triphosphate
... Recently, we identified a new thiamine derivative, adeno- sine thiamine triphosphate (AThTP). This compound was first discovered in E. coli, but it is also present in low amounts in plants and ...
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Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress
... total thiamine) in response to different conditions of metabolic stress that impair bacterial growth: carbon starvation, metabolic inhibition or dissipation of the electrochemical proton ...
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Adenylate Kinase-Independent Thiamine Triphosphate Accumulation under Severe Energy Stress in Escherichia Coli
... These results show that high amounts of ThTP (60% of total thiamine) can be synthesized from ThDP in the absence of AK activity. The phosphate donor is therefore unlikely to be ADP. Another obvious candidate is ...
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Biological functions of thiamine derivatives: Focus on non-coenzyme roles
... Introduction Thiamine (vitamin B1) is mainly known for its diphosphorylated derivatives (ThDP), an essential coenzyme in energy ...phosphorylated thiamine derivatives, most prominently thiamine ...
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Biochemistry of thiamine and thiamine phosphate compounds
... 9.1. Thiamine triphosphorylated derivatives The hypothesis of non-coenzyme roles of thiamine drove interest to ThTP present in small amounts in nervous tissues and was sometimes considered as a “neuroactive ...
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Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs
... processes. Thiamine added after pasteurization causes no organoleptic changes, and a thiamine-fortified fish sauce has been tested in ...of thiamine-fortified fish sauces (one sauce fortified at 2 ...
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Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study
... zidovudine triphosphate using AMS technology with high sensitivity, and we have successfully cross-validated these results using standard LC/MS/MS analysis 6 ...
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Thiamine and benfotiamine protect neuroblastoma cells against paraquat and ß- amyloid toxicity by a coenzyme-independent mechanism
... of thiamine (and ThDP) contribute only to a small extent to the protective effects of ...that thiamine protects against oxidative stress through indirect ...However, thiamine was ineffective. Our ...
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Augmentation sélective de l'expression protéique et de l'ARNm de la synthase du monoxyde d'azote dans les régions vulnérables du cerveau chez les rats déficients en thiamine
... Keywords : Thiamine Deficiency, Nitric Oxide (NO), Vascular endothelium, Nitric oxide synthase (NOS), Endothelial nitric oxide synthase (eNOS), Inducible nitric oxide synthase (iNOS), Ne[r] ...
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Thiamine Deficiency as a Cause for Acute Circulatory Failure: An Overlooked Association in Western Countries
... highlighting the importance of suspecting the diagnosis early, particularly in an emergency situation. Its prevalence has never been evaluated in western countries, and the literature is limited to a few case reports. To ...
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Three Common Intronic Variants in the Maternal and Fetal Thiamine Pyrophosphokinase Gene (TPK1) are Associated with Birth Weight
... of thiamine, a form of vitamin B1, to thiamine pyrophosphate ...in thiamine metabolism, and maternal thi- amine deficiency causes intra-uterine growth retarda- tion in rats (Butterworth, 1993b; ...
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Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response.
... Bornaviridae, which replicate into the nucleus, represents a danger signal that triggers the RIG-I mediated innate immunity and accounts for the massive and immediate IFN induction after infection. Although ...
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Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels.
... messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLC activation is a necessary step since inhibitors of PLC block the AR ( O Toole et al., 2000 ’ ). The production of IP3 by PLC activates ...
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Metabolomics analysis in rats with thiamine deficiency identifies key metabolites in vulnerable brain regions and suggests neural stem progenitor cells play a role in ameliorating metabolic dysfunction
... Vitamin B1 (thiamine) deficiency (TD) is the major cause of Wernicke's encephalopathy (WE) where cerebral function is impaired due to vulnerability (Hazell, 2009b). The underlying mechanism remains unclear, but ...
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Evidence for a “metabolically inactive” inorganic phosphate pool in adenosine triphosphate synthase reaction using localized 31P saturation transfer magnetic resonance spectroscopy in the rat brain at 11.7 T
... With the increased spectral resolution made possible at high fields, a second, smaller inorganic phosphate resonance can be resolved on 31 P magnetic resonance spectra in the rat brain. Saturation transfer was used to ...
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Variations in Cellular Responses of Mouse T Cells to Adenosine-5'-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage
... FigUre 2 | Adenosine-5 ′-triphosphate (ATP)-mediated cellular activities and P2X7 receptor (P2X7R) membrane expression in regulatory T lymphocytes (Tregs) and conventional T lymphocytes (Tconvs) with CD25 + ...
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Adsorption of nucleotides on biomimetic apatite: The case ofadenosine 5' triphosphate (ATP)
... Adenosine 5' triphosphate ( ATP) is a naturallyoccurring triphos phate nucleotide which is present in every cell. lt consists of a purine base (adenine). ribose, and three phosphate groups linked through �P ...
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Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension
... Ectonucleoside triphosphate diphosphohydrolase-1, the major vascular/immune ectonucleotidase, exerts anti-thrombotic and immunomodulatory actions by hydrolyzing extracellular nucleotides (danger ...
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