• Aucun résultat trouvé

TCR-T cell receptor

The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate

The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate

... thymocytes, TCR signaling in MHC-II-restricted thymocytes is more potent in promoting ThPOK ...by TCR specificity ...MHC-II-specific TCR signaling during lineage commitment has proven to be difficult ...

230

γδ T cell receptor ligands and modes of antigen recognition.

γδ T cell receptor ligands and modes of antigen recognition.

... a TCR ligand determining thymic differentiation and tissue homing of DETC ...in TCR-mediated antigen recognition and an alternative possibility is that it is somehow involved in TCR ligand ...the ...

19

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

... of TCR signaling in CD4 T cells Purified CD4 T cells were stimulated at 37°C in non-supplemented RPMI 1640 using pre- formed complexes of biotinylated anti-CD3 (clone 145-2C11, Biolegend, 30 μg/ml /10 7 cells), ...

18

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

... T-cell receptor (TCR) co-receptors such as CD8 increase detection performance, but the exact mechanism remains incompletely ...between TCR- transfected CD8+ and CD8 − Jurkat cells and surfaces ...

17

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

... the TCR-signaling pathway ( Voisinne et ...T cell provided an unprecedented quantitative picture of the LAT signalosome ( ...after TCR stimulation, compared with 13,261 and 2,486 for GRB2 and GRAP2, ...

26

Quantification of HTLV-1 Clonality and TCR Diversity.

Quantification of HTLV-1 Clonality and TCR Diversity.

... T cell repertoire? These questions are partially addressed by high- throughput sequencing techniques that enable identification of immunological and microbiological ‘‘species’’ in a ...T cell antigen ...

13

Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center

Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center

... stem cell transplantation (alloSCT) has first highlighted the potential of T cells to eliminate cancer ...T-cell receptor (TCR) coupled with one or more co-stimulatory domains, allowing to ...

15

Analysis and expression of a cloned pre-T cell receptor gene

Analysis and expression of a cloned pre-T cell receptor gene

... A glycosylated chain of 33 kD (gp33) is paired with TCRP proteins in a TCR,-transfected immature T cell line (SCB.29) from severe combined immunodeficient (SCID) mice (12), but could not[r] ...

7

RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor

RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor

... DISCUSSION The translation of tumor-reactive Vg9Vd2 T cells to clinical appli- cations has proven challenging, due to a limited understanding of the molecular mechanisms by which Vg9Vd2 T cells recognize their targets. ...

15

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

... Results Dwell time threshold for negative selection by pMHCI vs. pMHCII ligands To identify positive and negative selecting ligands for MHCII-restricted TCRs, we analyzed the development of I-A b - restricted, ...

30

CD5, an Undercover Regulator of TCR Signaling

CD5, an Undercover Regulator of TCR Signaling

... T cell receptor (TCR) that constantly scan peptides associated with major histocompatibility complexes ...(MHC). TCR engagement initiates a series of molecular events leading to cytokine ...

9

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

... T cell receptor (TCR) activation is modulated by mechanisms such as TCR endocytosis, which is thought to terminate TCR ...internalization, TCR continues to signal from a set of ...

17

Force Measurements of TCR/pMHC Recognition at T Cell Surface

Force Measurements of TCR/pMHC Recognition at T Cell Surface

... T cell receptor (TCR), of foreign peptides bound to major histocompatibility complex molecules (pMHC) on the surface of antigen presenting cells ...the TCR with pMHC raises enormous interest ...

41

Minimal encounter time and separation determine ligand-receptor binding in cell adhesion

Minimal encounter time and separation determine ligand-receptor binding in cell adhesion

... some receptor on the bead. The location of the first interacting receptor on the bead is randomly picked in the zone fulfilling d ≤ L , with the distance between the ligand and the receptor anchoring ...

15

Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.

Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.

... to cell killing in vivo, TRAIL signaling has to be tightly controlled at the cell ...the receptor, the adaptor protein FADD, the initiator caspases-10 and -8 and their inhibitor c-FLIP, a plethora of ...

14

GABAB receptor cell surface export is controlled by an endoplasmic reticulum gatekeeper

GABAB receptor cell surface export is controlled by an endoplasmic reticulum gatekeeper

... 4a,b ). To establish the amount of exogenous PRAF2 responsible for these motor phenotypes, PRAF2 was quantified in the VTA by immunoblot experiments with anti- PRAF2 antibodies ( Supplementary Figure S 6 b ). A linear ...

42

Un transporteur du magnésium - Nouvel intermédiaire dans les voies de signalisation du TCR

Un transporteur du magnésium - Nouvel intermédiaire dans les voies de signalisation du TCR

... kinases Lck, ZAP-70 ( zeta-chain-asso- ciated protein kinase of 70 kDa) et Itk (IL-2 inducible T-cell kinase) qui phos- phorylent la protéine PLC1 (phospho- lipase C) ainsi que d’autres protéines. La ...

3

Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase.

Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase.

... Methods Cell culture and immunoblot ...derived cell lines were previously described ...medium. Cell extracts and immunoblotting analysis were performed as described ...from Cell Signaling, ...

9

Natriuretic peptide receptor-C activation regulates vascular smooth muscle cell hypertrophy : molecular mechanisms

Natriuretic peptide receptor-C activation regulates vascular smooth muscle cell hypertrophy : molecular mechanisms

... 1.4.11.1 ROS Metabolism ROS are free radicals which possess a free electron in its outer orbit. The major free radicals are O2 - , OH - , NO and lipid radicals (Touyz & Schiffrin, 2004). H2O2, peroxynitrite, and ...

136

Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk

Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk

... cell speed were then extracted for each condition and plotted versus time and cell area, respectively. Fluorescence Recovery after Photobleaching Dual wavelength fluorescence recoveries after photobleaching ...

59

Show all 4620 documents...

Sujets connexes