Targeted therapies
The importance of jointly analyzing treatment administration and toxicity associated with targeted therapies: a case study of regorafenib in soft tissue sarcoma patients
... oral targeted therapies, it is critical to objectively and accurately report ...oral targeted therapies, different methods have been proposed to incorporate the dimension of time and the ...
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Bad Neighborhood: Fibrotic Stroma as a New Player in Melanoma Resistance to Targeted Therapies
... MAPK-targeted therapies to biomechanically reprogram melanoma cells towards a CAF-like cell state that confers them with the ability to autonomously create, through altered ECM deposition and stiffening, a ...
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Signal-Targeted Therapies and Resistance Mechanisms in Pancreatic Cancer: Future Developments Reside in Proteomics
... Global bottom-up approaches to analyse the proteome and post-translationally modified proteomes (phosphorylation, glycosylation, ubiquitination) are scarcely used in clinical PDAC. Indeed, proteomics can be used as an ...
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Targeted Therapies for Hereditary Peripheral Neuropathies: Systematic Review and Steps Towards a ‘treatabolome’
... / Targeted Therapies for Hereditary Peripheral Neuropathies ther effective ...novel therapies, which may in the future be added to the treatabolome ...
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ImmunoPET to help stratify patients for targeted therapies and to improve drug development
... antibody-based therapies and accelerating and improving drug ...expensive targeted therapies can be clearly demonstrated in large multicentre randomized clinical ...
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View of Cardiovascular Toxicity Due to Chemotherapy, Targeted Therapies, and Immunosuppressive Drugs: a Narrative Review
... and targeted therapies, with progressively higher cumulative ...of targeted the- rapies (monoclonal antibodies and tyrosine kinase inhibi- tors) have been described, including severe hypertension, ...
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Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma
... * Correspondence: odile.filhol-cochet@cea.fr; Tel.: +33-(0)4-38785645; Fax: +33-(0)4-38785058 Received: 30 November 2019; Accepted: 15 January 2020; Published: 17 January 2020 Abstract: Clear cell ...
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Development of Targeted Therapies for Liver Metastases: Is Heterogeneity a Major Issue?
... of Targeted Therapies for Liver Metastases: Is Heterogeneity a Major Issue? Vincent Castronovo, Arnaud Blomme, Bruno Dumont and Andrei Turtoi Metastasis Research Laboratory, GIGA Cancer, University of ...
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Targeted Therapies in Adult B-Cell Malignancies
... particularly 𝛾9𝛿2 T-cell, that may be purified for cellular therapy programs and activated by IL2 and bisphosphonates or IPH101 ([ 102 – 104 ] and personal data) combined with anti- CD20 mAbs [ 93 ]. It is surprising ...
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High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies
... Expression of FGFR in UPS (A) mRNA expression of FGFR1,2,3,4 by RT-qPCR in UPS from Institut Bergonie; samples are ordered on axis by group A (blue), B (red) and C (yel- low) according [r] ...
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[Interleukin-6 and epithelial tumours: new convincing arguments in favour of the use of IL-6 targeted therapies.]
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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View of Thrombotic microangiopathy during intensive care — a physiopathological classification for targeted therapies
... Le déficit sévère en ADAMTS13 apparaît comme étant spécifique du PTT, puisque l ’activité d’ADAMTS13 a été retrouvée sensiblement normale dans la majorité des cas de SHU, mais aussi au c[r] ...
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Targeted therapies for congenital myasthenic syndromes: systematic review and steps towards a treatabolome
... immunomodulating therapies are therefore not effective [ 13 ...administered therapies include AChE inhibitors such as pyridostigmine, which inhibits acetylcholine breakdown, and the potassium-channel ...
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View of Update on targeted therapies in pediatric pulmonary arterial hypertension
... Chez l ’enfant, l’éva- luation de la classe fonctionnelle n ’est pas simple et c’est pourquoi la plupart des enfants ayant une HTAP sont candi- dats à un traitement spécifique y compris [r] ...
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[Targeted therapies, prognostic and predictive factors in endocrine oncology].
... (O6-methylguanine-DNA methyltransferase), une enzyme impliquée dans la réparation de l’ADN, par méthylation de son promoteur était un facteur prédictif de réponse au[r] ...
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Regulatory T Cell-Enhancing Therapies to Treat Atherosclerosis
... anti-inflammatory therapies in coronary patients have confirmed that this is also true in humans Monocytes/macrophages are central cells in the atherosclerotic process, but adaptive immunity, through B and T ...
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RNA Splicing, Cell Signaling and Response to Therapies
... Recent findings These last years, the development of high-throughput studies together with appropriate bioinformatic tools have led to the identification of new cancer-specific splicing patterns that allow to distinguish ...
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RNA Splicing, Cell Signaling and Response to Therapies
... to targeted therapies as previously demonstrated for the Ikaros splice variant Ik6 that drives resistance to imatinib in BCR-ABL positive ALL cell lines [26], or for the V600E BRAF splice variant BRAF3-9, ...
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Contrast-enhanced and targeted ultrasound
... that CEUS is a useful tool for predicting early efficacy of sunitinib in metastatic renal cell carcinoma patients [125] . Hepatocellular carcinoma Hepatocellular carcinoma (HCC) is the second common malignant liver tumor ...
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Size of cannula for extracorporeal CO2 removal therapies
... can be used in clinics to decarboxylate blood externally for patients suffering from pulmonary insufficiencies like acute respiratory distress syndrome.. In this wor[r] ...
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