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T-cell receptor

The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate

The role of ThPOK and T cell receptor signaling in CD4+ versus CD8+ T-cell lineage fate

... non-T cell lineage capacity of the progenitors and eventually establish the T-cell ...T-cell receptor (TCR) αβ heterodimer on their cell surface that can recognize foreign or ...

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IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

... T cell receptor (TCR) activation is modulated by mechanisms such as TCR endocytosis, which is thought to terminate TCR ...T cell activation and survival after suboptimal TCR activation, as mice ...

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Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

... In the thymus, high affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate how developing T cells measure self- antigen affinity. We show ...

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Comment on “Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination”

Comment on “Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination”

... T-cell receptor (TCR) repertoire analysis has clearly gained the status of a major tool to profile the immune response in health and ...T cell subsets, it still remains problematic to assign a clear ...

5

A Bayesian framework for high-throughput T cell receptor pairing

A Bayesian framework for high-throughput T cell receptor pairing

... t cell receptors from high- throughput sequencing: dealing with promiscuity in tcrα and tcrβ ...t cell receptor sequences that differ from the t cells in adjacent mucosal ...

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A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

... The interaction between the TCR and MHC-peptide complexes leads to the initiation of TCR signaling and represents a key step for the orchestration of the adaptive immune response. Indeed, the intracellular signaling ...

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Analysis and expression of a cloned pre-T cell receptor gene

Analysis and expression of a cloned pre-T cell receptor gene

... A glycosylated chain of 33 kD (gp33) is paired with TCRP proteins in a TCR,-transfected immature T cell line (SCB.29) from severe combined immunodeficient (SCID) mice (12), but could not[r] ...

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Numerical Modelling Of The V-J Combinations Of The T Cell Receptor TRA/TRD Locus

Numerical Modelling Of The V-J Combinations Of The T Cell Receptor TRA/TRD Locus

... 1 CNRS, Laboratoire TIMC-IMAG, UMR 5525, Grenoble, France, 2 INSERM, Institut Albert Bonniot, Grenoble, France, 3 Universite´ Joseph Fourier-Grenoble I, Faculte´ de Me´decine, Grenoble, France Abstract T-Cell ...

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Cloning and comparative analysis of the human pre-T-cell receptor a-chain gene

Cloning and comparative analysis of the human pre-T-cell receptor a-chain gene

... Amino acid sequence comparison of human pTa with the mouse pTa molecule reveals high sequence homology in the extracellular as well as the transmembrane region.. In contrast, the cytopla[r] ...

6

γδ T cell receptor ligands and modes of antigen recognition.

γδ T cell receptor ligands and modes of antigen recognition.

... T cell clone (V 9V 2) with dual specificity has been reported to recognize mycobacterial antigens in a non-MHC γ δ restricted fashion and a tetanus toxoid (TT) peptide in the contect of an MHC-II molecule (DRw53) ...

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RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor

RhoB Mediates Phosphoantigen Recognition by Vg9Vd2 T Cell Receptor

... of cell lines from the Centre d’Etude du Polymorphisme Humain (CEPH), which contains a large collection of EBV-transformed B cell lines (EBV-LCLs) obtained from several family pedigrees ( Dausset et ...CEPH ...

15

Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses

Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses

... T-cell receptor ab-Alexa647 or -Alexa488 (R73), CD4-PECy7 (OX35), interleukin-17 (IL-17) –allophycocyanin (APC) (ebio17B7), interferon g (IFN-g) –phycoerythrin (PE), and anti-human phosphotyrosines (p-Tyr) ...

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CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment

... T-cell receptor; T-cell triggering; spreading; 2D binding kinetics; laminar flow chamber; interference reflection microscopy; reflection interference contrast microscopy ...target cell, or ...

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Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse

Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse

... ing an available pool of pS727­STAT1 to prime circulating Thp for rapid activation of STAT1­driven gene expression. Cytokine receptor exclusion from the IS IL4R–STAT6 signaling induces the exclusion of the IFNGR ...

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Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center

Chimeric Antigen Receptor-T-Cell Therapy for B-Cell Hematological Malignancies : An Update of the Pivotal Clinical Trial Center

... stem cell transplantation (alloSCT) has first highlighted the potential of T cells to eliminate cancer ...T-cell receptor (TCR) coupled with one or more co-stimulatory domains, allowing to transduce ...

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Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk

Enhanced cell-cell contact stability and decreased N-cadherin-mediated migration upon fibroblast growth factor receptor-N-cadherin cross talk

... N-cadherin cell surface accumulation by reducing its ...of cell surface expression of ...separate cell membrane and internal cell areas on each ...following cell surface ...

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Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma.

Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma.

... ligation (lane 1 compared to lane 4) and treatment with dasatinib (100nM) completely blocked this effect while SP600125 that affect JNK did not. Similarly, PP2 decreased BCR-induced phospho-Tyr397 LYN in pri- mary MCL ...

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Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.

... for receptor activation by mutations lacking cysteine correlates with ligand independent ...Neu receptor tyrosine kinase 14-16 and the dimerization inducing muta- tions in MPL 17,18 that was identified in ...

5

Regulation of T cell response by a new member of the TNF receptor family

Regulation of T cell response by a new member of the TNF receptor family

... f asL and LIGHT, both of which can reversely transduce positive costimulatory signais into T ceils, we have developed a tumour vaccine based on surface TR6 expression on tumour celis.. I[r] ...

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Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.

Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussion.

... totic Receptor Agonists), are attractive compounds for can- cer therapy due to their ability to induce tumor regression without significant side effects ...

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