t cell activation
Dok-4 is a novel negative regulator of T cell activation.: Dok-4 and T cell activation
... the activation of ERK without altering other key signalling events such as the tyrosine phosphorylation of PLC- γ1 or the activation of ...of cell adhesion (43), but it has also been reported to ...
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Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation
... T cell activation (Lil- lemeier et ...TCR activation, microclusters contain- ing LAT and SLP-76, another adapter protein that binds phosphorylated LAT, transiently associate with the TCR and undergo ...
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In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation
... Results Characterization of CD28 tail-less KI mice To address the role of the CD28 cytoplasmic tail in T cell activation, we generated CD28 tail- less KI (CD28 KI) mice. This truncated CD28 protein, CD28 ...
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T-cell activation discriminates subclasses of symptomatic primary humoral immunodeficiency diseases in adults.
... T-cell activation, suggesting that the HLA-DR + activation marker could help to discriminate ...of activation markers would help in deciphering the role of T-cell activation, ...
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CD8 Co-Receptor Enhances T-Cell Activation without Any Effect on Initial Attachment
... T-cell activation and lifetime of TCR–pMHC bonds, Liu et ...a cell-free system including only TCR and ...lymphocyte activation [ 19 ], and this may involve the p56lck Src kinase associated ...
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Role of the Wiskott-Aldrich syndrome protein in human CD8+ T cell activation and effector function
... T cell activation. Another possible role for WASP in T cell proliferation could be explained by its role in cytokinesis 156,159,238,239 ...of cell division during which cytoplasmic content and ...
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Soluble HLA-I/Peptide Monomers Mediate Antigen-Specific CD8 T Cell Activation through Passive Peptide Exchange with Cell-Bound HLA-I Molecules
... T cell–induced activation upon direct incubation with soluble monomers or with the corresponding peptides at equivalent molar ...cell activation. Kinetic experiments were conducted by ...
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CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates
... T cell depletion (74–77). The significant control of T cell activation with FR104/sirolimus may blunt these T cell functions, and indeed, previous results in murine models suggested that ...
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The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation
... Daiki Mori 1,2 * , Claude Gr´egoire 1 * , Guillaume Voisinne 1 , Javier Celis-Gutierrez 1,2 , Rudy Aussel 1 , Laura Girard 1,2 , Mylène Camus 3 , Marlène Marcellin 3 , J´er´emy Argenty 1 , Odile ...
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Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation
... organized cell–cell junction named the immunological synapse (Agu¨era-Gonzalez et al, ...T-cell activation (Valitutti et al, 1995; Campi et al, 2005; Nguyen et al, 2008; Lasserre et al, 2010; ...
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Contribution of ROS and metabolic status to neonatal and adult CD8 + T cell activation
... interaction between the redox state and cellular metabolism and its influence on the activation of human CD8 + T lymphocytes. The nodes can be divided into three main categories: mitochondrial nodes (upper left), ...
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Dynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation
... Shuangding Wu Shuangding Wu 11 , , Stefan Vasile Stefan Vasile 22 , , Russel Dahl Russel Dahl 22 , , Li Yang Li Yang 22 , , Lucia Lucia Musumeci Musumeci 44 , , Dana Francis Dana Francis[r] ...
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Cytokine-capture nanoparticles to quantify IL-2 concentrations within the immunological synapse during T cell activation
... Although there are patents that claim the use of nanoparticles as a substrate to present multiple p-MHC molecules, the cytokine capture device still has the advantage of q[r] ...
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Tumor necrosis factor receptor family costimulation increases regulatory T‐cell activation and function via NF‐κB
... 4 Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK 5 Centre de Recherche en Canc´ erologie de Lyon, UMR INSERM 1052, CNRS 5286, Universit´ e Claude Bernard Lyon 1, Labex DEVweCAN, Centre L´ eon B´ erard, ...
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Deoxynivalenol affects proliferation and expression of activation-related molecules in major porcine T-cell subsets
... in activation and costimulation of porcine T ...T-cell activation, providing a molecular basis for some of the described immunosuppressive effects of ...T-cell activation and the ...
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A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.
... or activation of the H3K14 specific HAT activity seems to be largely dependent on H3S10 phosphorylation, while inhibitors of the nucleosomal response did not affect the association of the H3K9-specific ...
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Cell cycle activation of hematopoietic progenitor cells increases very late antigen-5-mediated adhesion to fibronectin.
... vascular cell adhesion molecule (VCAM)-1 expressed by stromal cells ...between cell cycle transit and integrin expression and/or func- tion was not directly ...
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Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation
... mast cell chemokine and cytokine production: involvement of G-protein activation Opiates and their synthetic counterparts, opioids, have important pharmacologic actions that provide relief for pain and ...
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Modeling and experimental validation of radiation-cell interaction in radiotherapy by photon activation of gold nanoparticles
... photon activation of gold nanoparticles Rachel Delorme 1 , Mathieu Agelou 1 , Hélène Elleaume 2 , Christophe Champion 3 1 CEA,LIST, Laboratoire de Modélisation, Simulation et Systèmes, F-91191 Gif-sur-Yvette cedex ...
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Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro
... receptor activation is able to modulate directly RGC responses by attenuating the NMDA-induced increase in RGC spiking activity (Figure ...2 activation counteracting the effect of Y 1 activation by ...
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