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Sodium channel

Widespread Mutations in Voltage-Gated Sodium Channel Gene of Cimex lectularius (Hemiptera: Cimicidae) Populations in Paris

Widespread Mutations in Voltage-Gated Sodium Channel Gene of Cimex lectularius (Hemiptera: Cimicidae) Populations in Paris

... are visible during the day, several bed bugs niches visible everywhere 2.2. Molecular Genotyping of the kdr Gene The extraction of DNA was carried out using Chelex 10% (Bio-Rad, California, USA) [ 30 ]. The DNA ...

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Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and migraine

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and migraine

... voltage-gated sodium channel Na V ...persistent sodium current in the interneuron and epileptogenic mutations by decreasing the sodium conductance in the ...

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Biological concepts in human sodium channel epilepsies and their relevance in clinical practice

Biological concepts in human sodium channel epilepsies and their relevance in clinical practice

... University of Southern Denmark Biological concepts in human sodium channel epilepsies and their relevance in clinical practice Brunklaus, Andreas; Du, Juanjiangmeng; Steckler, Felix; Ghanty, Ismael I.; ...

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Sodium-channel blocker challenge in the familial screening of Brugada syndrome: safety and predictors of positivity

Sodium-channel blocker challenge in the familial screening of Brugada syndrome: safety and predictors of positivity

... Sodium- channel blocker challenge in the familial screening of Brugada syndrome: safety and predictors of positivity.4. M AN US CR IP T AC CE PT ED 1.[r] ...

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Mechanisms of sodium channel clustering and its influence on axonal impulse conduction

Mechanisms of sodium channel clustering and its influence on axonal impulse conduction

... A second component related to the nodal capacitance is the membrane area occupied by the node of Ranvier. Increasing the size of the nodes of Ranvier can alter con- duction velocity, such that an increase in nodal length ...

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CK2 accumulation at the axon initial segment depends on sodium channel Nav1

CK2 accumulation at the axon initial segment depends on sodium channel Nav1

... a b s t r a c t Accumulation of voltage-gated sodium channel Nav1 at the axon initial segment (AIS), results from a direct interaction with ankyrin G. This interaction is regulated in vitro by the protein ...

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Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation.

Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation.

... Electrophysiological measurements Total sodium currents (INa) and TTX-R Na v 1.8 currents were recorded from single, large-soma DRG neurons (Capacitance >70 pF) in the whole-cell patch-clamp con- figuration 14 ...

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Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa

Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa

... Results: The infection of the different mouse strains evoked regulation of α and β ENaC mRNA. Following Pseudomonas instillation, the expression of αENaC mRNA decreased to a median of 43% on days 3 and 7 after infection ...

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Lacosamide and sodium channel-blocking antiepileptic drug cross-titration against levetiracetam background therapy

Lacosamide and sodium channel-blocking antiepileptic drug cross-titration against levetiracetam background therapy

... Patients aged ≥18 years were included if they had a diagnosis of focal epilepsy and, despite treatment with a combination of LEV and a SCB, were still experiencing seizures (at least one seizure/4 weeks within the 8- ...

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Skeletal muscle sodium channelopathies

Skeletal muscle sodium channelopathies

... muscle sodium channelopathies are known since several decades to manifest as autosomal dominant syndromes with different degrees of recurrent attacks of muscle weakness (periodic paralyses) or muscle stiffness ...

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Ion Channel Trafficking: Control of Ion Channel Density as a Target for Arrhythmias?

Ion Channel Trafficking: Control of Ion Channel Density as a Target for Arrhythmias?

... channels, sodium channel, arrhythmias, cardiac, trafficking, accessory proteins FUNCTIONAL EXPRESSION OF ION CHANNELS IN THE SARCOLEMMA AND CARDIAC EXCITABILITY The function of the heart is governed by the ...

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L’oxybate de sodium pour des sédations profondes en fin de vie

L’oxybate de sodium pour des sédations profondes en fin de vie

... de sodium effectuées à l’unité de soins palliatifs nous permettent de penser qu’il est au moins aussi efficace et avec un profil d’effets indésirables meilleur que le midazolam pour des sédations profondes et ...

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Accounting for channel constraints in joint source-channel video coding schemes

Accounting for channel constraints in joint source-channel video coding schemes

... First, Section 3.2 presents the transmission model, then Section 3.3 describes the classical minimum MSE solution under a total power constraint, proposed in [LP76], with an alterna- tive proof involving majorization ...

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KV4.3 Expression Modulates NaV1.5 Sodium Current

KV4.3 Expression Modulates NaV1.5 Sodium Current

... both sodium and potassium channels mainly localize at the axon initial segment (AIS), a subcellular region involved in AP ...Ion channel recruitment to the AIS is highly dependent on the cytoskeleton and ...

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Modeling of underexpanded reactive CO2-into-sodium jets, in the frame of sodium fast reactors

Modeling of underexpanded reactive CO2-into-sodium jets, in the frame of sodium fast reactors

... the sodium pressure (atmospheric pressure) and the stagnation pressure of the gas jet at injection velocity of 125 m/s was calculated from the isentropic assumption as 20 ...liquid sodium (meaning that the ...

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Étude de l'effet modérateur de sels sur la réaction sodium-eau, pour le "lavage" d'assemblages de combustible irradiés issus de réacteurs à caloporteur sodium

Étude de l'effet modérateur de sels sur la réaction sodium-eau, pour le "lavage" d'assemblages de combustible irradiés issus de réacteurs à caloporteur sodium

... Le sodium est un matériau qui réagit avec le di oxygène de ...de sodium. Pour ces raisons, on cherche à protéger le sodium de l’humidité de l’atmosphère qui est aussi un facteur de modification de ...

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Teaching Sodium Fast Reactors in CEA

Teaching Sodium Fast Reactors in CEA

... the Sodium Fast Reactor (SFR) has the most comprehensive technological basis as result of the experience gained from worldwide operation of several experimental, prototype, and commercial size reactors since the ...

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Influence de la microstructure de la thorine yttriée sur sa tenue au sodium, en vue de réaliser des sondes à oxygène dans les réacteurs au sodium de IVème Génération.

Influence de la microstructure de la thorine yttriée sur sa tenue au sodium, en vue de réaliser des sondes à oxygène dans les réacteurs au sodium de IVème Génération.

... 27 D’ici à 2030, la demande énergétique aura vraisemblablement doublé sous l’effet conjugué de l’augmentation progressive de la population mondiale et de la croissance économique des pays émergents. Afin d’y répondre ...

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Condensat de Bose-Einstein de sodium dans un piège mésoscopique

Condensat de Bose-Einstein de sodium dans un piège mésoscopique

... du sodium, avec des parois recouvertes d’un traitement particulier, puis étudié pour différentes espèces atomiques et différents substrats [ 134 , 136 , 137 , 138 , 139 , 140 , 141 ...de sodium pour charger ...

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Evaluation of the Physical Stability of Zinc Oxide Suspensions Containing Sodium Poly-(acrylate) and Sodium Dodecylsulfate

Evaluation of the Physical Stability of Zinc Oxide Suspensions Containing Sodium Poly-(acrylate) and Sodium Dodecylsulfate

... Polymers and surfactants are used together in several applications. As a result, interactions between polymers and charged surfactants in aqueous solutions have attracted increasing attention because of their complex ...

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