Signaling pathway
Signaling pathway switch in breast cancer.
... factors FOXO are downstream of the PI3K/AKT and JUN/MAPK cascades. FOXOs play a major role in the regulation of both the cell cycle and metabolism [11]. They prevent stem cells to accumulate ROS and allow DNA repair or ...
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UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway
... Fan Zhang 1 , Hui-zeng Lv 2 , Ji-ming Liu 2 , Xiao-yong Ye 2 , Cun-chuan Wang 1* > Colon cancer is a common cause of cancer- related death worldwide. However, the underlying mechanism of tumor progression of colon ...
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Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation
... retrograde signaling pathway (RTG) and the gen- eral control of amino acids ...ing pathway, representing the main control hub for nitrogen consumption [ 8 , 10 , 11 ...
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Hippo/YAP Signaling Pathway: A Promising Therapeutic Target in Bone Paediatric Cancers?
... to signaling pathways such as the Wnt pathway and the TGF-β ...other signaling pathways such as Wnt, sonic hedgehog, or the Hippo signaling pathway cooperate with the TGF-β ...
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Acute Exposure to Zearalenone Disturbs Intestinal Homeostasis by Modulating the Wnt/β-Catenin Signaling Pathway
... (ER) signaling pathway, which has an anti-inflammatory [ 8 , 11 , 12 ], anti-apoptotic and proliferating effect [ 3 , 13 , 14 ...and signaling is mainly activated directly upon DNA binding in the ...
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Characterization of protein-protein interactions involved in auxin signaling pathway in tomato
... auxin signaling pathway: ARF being transcription factors that activate or repress the auxin-responsive gene expression, Aux/IAA repressing the activity of ARF and having its turnover controlled by the ...
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A redox-sensitive signaling pathway mediates pro-angiogenic effect of chlordecone via estrogen receptor activation
... redox signaling pathway, NOS appears to be a target of NADPH oxidase since apocynin pre-treatment was shown to decrease eNOS phosphorylation on its positive regulatory site (Ser ...redox signaling ( ...
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Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway
... Beyond the importance of the therapeutic aspect of identifying new synthetic peptides with antidiabetic potential, the present work also highlights that circulating level of an endogenous peptide could protect beta cells ...
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Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species
... molecular signaling that allows these plants to recognize their fungal and bacterial ...symbiotic signaling responses to AM fungi in roots of both Casuarina glauca and Discaria tri- nervis, actinorhizal ...
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Akt signaling pathway: a target for radiosensitizing human malignant glioma
... The development of Akt and STAT3 inhibitors has been a goal of pharmaceutical companies since the discovery that these pathways are often activated in numerous human cancer such as melanoma, myeloma, brain cancer, ...
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The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway
... /AC/cAMP/PKA pathway discovered herein may have significance far beyond the ␣2A- AR- and TRPM8-mediated sensory transduction and antinoci- ception, as TRPM8 is known to be present in a number of tis- sues outside ...
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Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers
... Edited by: Se ´ bastien Roger, Universite ´ de Tours, France Reviewed by: Irene Frischauf, Johannes Kepler University of Linz, Austria Heike Wulff, University of California, Davis, United States *Correspondence: Raphael ...
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Bone morphogenetic protein signaling pathway plays multiple roles during gastrointestinal tract development.
... BMP signaling pathway activation in the developing GI ...BMP signaling pathway is activated in the mesoderm, the endoderm and the enteric nervous system (ENS) of the developing chick GI tract, ...
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A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
... reverse signaling. To further elucidate the signaling pathway downstream of activated Sema4A, our goal was to identify proteins that interact with its intracellu- lar ...reverse signaling ...
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Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway
... 2 Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Service d’Hématologie Biologique, F-75013 Paris, France * Correspondence: brigitte.bauvois@crc.jussieu.fr Abstract: Besides their antiviral ...
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The importance of the Hedgehog signaling pathway at the level of the blood-brain barrier
... (Hh) signaling pathway in adult tissues plays an important role in vascular proliferation, differentiation and tissue ...(Hh) pathway as a signaling cascade involved in preserving and ...
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Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes
... provided a new avenue and been considered having great potential. Ursolic acid (UA) is a natural pentacyclic triterpenoid and present in many different plants, fruits and herbs. Accumulating evidence has shown that UA ...
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Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity–signaling pathway
... (PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis (Daam1), has been proposed to regulate cell actin cytoskeleton and microtubule (MT) reorganization for ...
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The Notch signaling pathway involvement in innate lymphoid cell biology
... Notch pathway was determined as active in a sub-fraction of fetal liver aLP enriched in ILC2P and devoid of LTiP thanks to the use of transcriptomic analyses on single ...Notch signaling to express ILC ...
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SHH Signaling Pathway Drives Pediatric Bone Sarcoma Progression
... (SHH) pathway has taken place within the cancer research ...SHH signaling pathway in skeletal development, pediatric bone sarcoma progression and the related therapeutic options that may be possible ...
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