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scorpion toxin

Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine.: Redox-sensitive RyR stimulation by Maurocalcine

Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine.: Redox-sensitive RyR stimulation by Maurocalcine

... The scorpion toxin maurocalcine (MCa), a 33-mer basic peptide cross-linked by three disulfide bridges that crosses cell membranes within 1-2 min [13, 14] is a high-affinity and reversible RyR1 ...

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Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.: Electrostatic interactions between segments IIS2, IIS3 and IIS4 of Na+ channel.

Beta-scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.: Electrostatic interactions between segments IIS2, IIS3 and IIS4 of Na+ channel.

... scorpion toxin action strongly suggests that they play a similar and/or a cooperative role in the voltage-sensing structure of sodium ...for toxin binding, even at negative membrane potentials where ...

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Maurocalcine-derivatives as biotechnological tools for the penetration of cell-impermeable compounds: Technological value of a scorpion toxin

Maurocalcine-derivatives as biotechnological tools for the penetration of cell-impermeable compounds: Technological value of a scorpion toxin

... 9 1- Structural evidences The 3-D solution structure of maurocalcine was determined by 1 H-NMR in 2000 (11). The peptide folds according to an inhibitor cysteine knot (ICK in short) also found in other peptides active ...

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Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane.

Transduction of the scorpion toxin maurocalcine into cells. Evidence that the toxin crosses the plasma membrane.

... peptide toxin isolated from the scorpion Scorpio maurus ...the toxin. The toxin complex efficiently penetrated in various cell types without requiring metabolic energy (low temperature) or ...

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Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.: Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin.: Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin

... β-scorpion toxin to shift the voltage dependence of activation before and after a positive prepulse are illustrated as bar graphs in ...β-scorpion toxin action, as a mutation at these ...

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Towards the charge-density study of proteins: a room-temperature scorpion-toxin structure at 0.96 Å resolution as a first test case

Towards the charge-density study of proteins: a room-temperature scorpion-toxin structure at 0.96 Å resolution as a first test case

... 4. Discussion As in other protein structures at similar resolution, re®nement with SHELXL97 has shown the relevance of the anisotropic ADP re®nement. However, the use of the more sophisticated model for atomic electron ...

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Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine.

Small efficient cell-penetrating peptides derived from scorpion toxin maurocalcine.

... SUMMARY Maurocalcine is the first demonstrated example of an animal toxin peptide with efficient cell penetration properties. While it is a highly competitive cell penetrating peptide (CPP), its relatively large ...

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Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold.

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold.

... uncharacterized scorpion toxin-like pep- tides (BoTx758 from Buthus occitanus israelis and Hj1a from Buthotus judaicus) as significant matches ( Figure 2 ...known scorpion venom ICK peptides with Ca ...

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Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins.: Key Residues of SK3 Channel for Selective Toxin Recognition

Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins.: Key Residues of SK3 Channel for Selective Toxin Recognition

... governing scorpion toxin sensitivity for SK3 ...the toxin sensitivity of SK3 channels through differential electrostatic repulsion forces ...while toxin R 13 hangs just above the two rings of ...

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Distinction between Pore Assembly by Staphylococcal α-Toxin versus Leukotoxins

Distinction between Pore Assembly by Staphylococcal α-Toxin versus Leukotoxins

... In conclusion, none of the observations obtained in this work favor a large unfolding and the structural loca- tion for interactions with two adjacent protomers along the lumen of the pore for the N-terminal extremities ...

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Atomic structure of anthrax protective antigen pore elucidates toxin translocation

Atomic structure of anthrax protective antigen pore elucidates toxin translocation

... Anthrax toxin, comprising protective antigen (PA), lethal factor (LF) and edema factor (EF), is the major virulence factor of Bacillus anthracis, an agent that causes high mortality in human and ...

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In vitro hepatic biotransformation of the algal toxin pectenotoxin-2

In vitro hepatic biotransformation of the algal toxin pectenotoxin-2

... Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspeciic binding to microsomes.[r] ...

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Pertussis Toxin Reduces the Number of Splenic Foxp3 + Regulatory T Cells

Pertussis Toxin Reduces the Number of Splenic Foxp3 + Regulatory T Cells

... Roland S. Liblau* Pertussis toxin (PTx) is a bacterial toxin used to enhance the severity of experimental autoimmune diseases such as experimental autoimmune encephalomyelitis. It is known to promote ...

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Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B

Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B

... of Jurkat cells after 36 h exposure to HducCDT WT and mutants at the indicated concentrations. NT: Untreated cells. 2.3. Effects of the CdtB Mutations on CDT-Induced DNA Damage To further compare the defects associated ...

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Regulation of mucosal immune responses by anthrax edema toxin derivatives.

Regulation of mucosal immune responses by anthrax edema toxin derivatives.

... [49, 50] . 3.2.1.2 Vaccines against enteric infections The World Health Organization (WHO) estimates that diarrheal diseases account for 15-34 % of all deaths in certain countries and cause 4 to 6 million deaths a year, ...

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Delivery of biomolecules into mammalian cells using anthrax toxin

Delivery of biomolecules into mammalian cells using anthrax toxin

... Translocation efficiency of cargos at the C-terminus of LFN (or LFN-DTA) has been analyzed using three common laboratory assays: planar lipid bilayer,37 protein synt[r] ...

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Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops

Intimin, tir, and shiga toxin 1 do not influence enteropathogenic responses to shiga toxin-producing Escherichia coli in bovine ligated intestinal loops

... Shiga toxin-producing Escherchia coli (STEC) comprises a group of attaching and effacing (A/E) enteric pathogens of animals and ...Shiga toxin 1 or intimate bacterial attachment to the intestinal ...

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Structural insights into the AapA1 toxin of Helicobacter pylori

Structural insights into the AapA1 toxin of Helicobacter pylori

... FIGURE LEGENDS Figure 1: Toxicity and cellular localization of the AapA1 peptide in H. pylori. (A) Schematic representation of the inducible constructs expressing either the AapA1 ORF of H. pylori 26695 strain alone ...

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Structural insights into chaperone addiction of toxin-antitoxin systems

Structural insights into chaperone addiction of toxin-antitoxin systems

... SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to ...

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Escherichia coli STb toxin induces apoptosis in intestinal epithelial cell lines

Escherichia coli STb toxin induces apoptosis in intestinal epithelial cell lines

... 4. APOPTOSIS INDUCED BY STb IS DOSE-DEPENDENT Apoptotic indexes based on fragmented nuclei of HRT-18 and IEC-18 cells treated with increasing amounts of STb toxin revealed cell death occurs in a dose-dependent ...

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