S4-S5 linker
hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state
... channel is reversible. Cells co-transfected with the E544C S4-S5 L (+3) peptide and the L666C channel were incubated for 2 hours with tbHO 2 , followed by 2 hours incubation with 10 mM DTT. This double ...
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Couplage entre les régions IIS4-S5 et IIS6 lors de l’activation du canal calcique CaV2.3
... the S4 helix of each domain that most certainly accounts for the voltage sensitivity of these ...the S4 sensors translate into channel opening remains elusive in Ca 2+ ...amphipathic S4-S5 ...
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Influence des glycines du lien S4-S5 sur le couplage électromécanique des canaux ioniques dépendants du voltage
... Abstract Voltage-gated potassium channels are formed of four subunits, each one with six transmembrane segments (S1-S6) and a loop (p-loop) between S5 and S6 at the level of the pore. It is known that the voltage ...
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Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism
... the S4-S5 linker sequences of the four domains differ, we explored if co-transfecting two activating peptides exerts a stronger effect on hNa V ...which S4-S5 effects are not strong ...
19
BBF RFC 37: Fusion protein BioBrick assembly standard with optional linker extension
... BioBrick Assembly standards are easy to use for cloning and some newly introduced standards also enable protein in-frame fusions. For precise structure building using protein or peptide domains a precise length of a ...
6
All-sky Search for Periodic Gravitational Waves in the Full S5 LIGO Data
... full S5 run required a rework of the PowerFlux code, resulting in a factor of 10 improvement in speed when iterating over multiple values of possible signal frequency deriva- tive, while reporting more detailed ...
20
BBF RFC 36: Fusion protein BioBrick assembly standard with optional linker extension
... BioBrick-NIC-II: Schematic presentation of three different cloning strategies in multiple-cloning site of BB-NIC-II vector. Note: Each type of cloning leaves different extension of amino acids that could be used to ...
6
All-sky search for periodic gravitational waves in the full S5 LIGO data
... full S5 run required a rework of the PowerFlux code, resulting in a factor of 10 improvement in speed when iterating over multiple values of possible signal frequency deriva- tive, while reporting more detailed ...
20
A Low-cost, High-coverage Legal Named Entity Recognizer, Classifier and Linker
... 5 Developing a Named Entity Linker The Named Entity Linking task consists in assigning YAGO URIs to the Wikipedia mentions, as shown in Example 2. The total number of entities found in the selected documents is ...
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Structural and electrical properties of Cu2Zn(Sn1−xSix)S4 (x=0, x=0.5) materials for photovoltaic applications
... The analysis of the dispersion of the frequency of real and imaginary components of the complex imped- ance allowed us to determine an equivalent electrical circuit for the CZTS (A0) com[r] ...
9
Procédures de traitement de données pour houlographe marégraphe seadata modèle 635 et courantomètre électromagnétique s4 interocean
... A cet effet, le SEADATA modèle 12 dont dispose l'IFREMERpour ses données météorologiques a été adapté auxca- ractéristiques des enregistrements de houle et de marée[r] ...
5
Remarkable Pressure Responses of Metal–Organic Frameworks: Proton Transfer and Linker Coiling in Zinc Alkyl Gates
... * S Supporting Information ABSTRACT: Metal −organic frameworks demonstrate a wide variety of behavior in their response to pressure, which can be classi fied in a rather limited list of categories, including anomalous ...
7
On Computational Interpretations of the Modal Logic S4 IIIb. Confluence, Termination of the $\lambda\mbox{ev}Q_H$-Calculus
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
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Polycarboxylated dextran as a multivalent linker: synthesis and target recognition of the antibody–nanoparticle bioconjugates in PBS and serum
... Table S1: The study of various succinic anhydride excesses in reaction with 40 kDa plain dextran. The estimates from 1 H NMR spectra are based on the comparison of the integrals corres[r] ...
4
In Search of a Phosphorus Dendrimer-Based Carrier of Rose Bengal: Tyramine Linker Limits Fluorescent and Phototoxic Properties of a Photosensitizer
... Previously, non-covalent complexes based on a phosphorus dendrimer and RB have been evaluated in vitro. The formation of non-covalent complexes [ 19 , 33 ] and their promising application in PDT [ 20 ] have been ...
21
Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells.
... DISCUSSION Redirecting the cytotoxic potential of leukocytes to eliminate tumor cells has been a major impulse for the development of bsAbs for cancer immunotherapy. FcγRIIIa is an attractive candidate to recruit ...
34
Impacts of the Imidazolate Linker Substitution (CH3, Cl, or Br) on the Structural and Adsorptive Properties of ZIF-8
... of linker) is triggered by a repacking of nitrogen molecules thereby inducing this “gate opening” or “swing ...the linker on the flexible/stiff structural nature of three isoreticular ZIFs of SOD ...
27
Polycarboxylated dextran as a multivalent linker: synthesis and target recognition of the antibody–nanoparticle bioconjugates in PBS and serum
... Although it is highly desirable to produce NPs with high density of antibodies on their surface, it is more difficult to estimate how many antibodies are immobilized in their active mode and orientation. To investigate the ...
10
Expression et purification de l'hélice transmembranaire S5 du canal potassique hERG et étude par RMN du rôle du segment extracellulaire ILE583-TYR597 dans le syndrome du long QT
... Comme il le sera démontré dans le prochain chapitre, les PFG furent utilisés afin de quantifier l'association d'un peptide provenant du canal hERG et l'association [r] ...
109
The State-of-the-Art in Sensor Technology for Demand-Controlled Ventilation, PERD S5-42: Final Report
... strategies. Unreliable sensor technology was one of the main barriers to widespread implementation of the DCV system. Various sensors were evaluated for their potential for the DCV cont[r] ...
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