26S proteasome
COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.
... and 26S Proteasome-dependent Regulation of SCF TIR1 Accumulation in Arabidopsis * □ S Received for publication, December 2, 2008, and in revised form, January 14, 2009 Published, JBC Papers in Press, ...
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The ubiquitin/26S proteasome system in plant-pathogen interactions: a never-ending hide-and-seek game
... Role of ubiquitination in plant defence About 20% of A. thaliana gene expression changes under pathogen attack (Rietz & Parker, 2007) and the up-regulation of general components of UPS have commonly been observed in ...
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Circulating 20S proteasome for assessing protein energy wasting syndrome in hemodialysis patients
... ubiquitin- proteasome proteolytic system (UPS) is crucial for the atrophying process, notably in chronic kidney disease (CKD) [ 3 , 4 ...The 26S protea- some consists of a core particle with proteolytic ...
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Proteasome inhibitors to alleviate aberrant IKBKAP mRNA splicing and low IKAP/hELP1 synthesis in familial dysautonomia
... and/or 26S proteasome. Interestingly, several agents targeting the 26S proteasome are already available in cancer treatment and new drugs targeting the proteasome are continuously being ...
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PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ
... 20S proteasome is a multimeric “barrel-like” protease that bears multiple peptidase ...the 26S proteasome that specifically recognizes and degrades polyubiquitylated proteins (2, ...20S ...
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Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins
... the 26S proteasome is sensitive to oxidative stress because it partially dissociates into 20S proteasome 41 , 42 ...the 26S proteasome and the ubiquitin system, we separated the study ...
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Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress
... the 26S regulatory subunit 6A also known as the 26S proteasome AAA-ATPase subunit (Rpt5) of the 19S proteasome complex responsible for recognition, unfolding and translocation of substrates ...
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Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia
... after proteasome inhibition in FLT3-ITD mutant driven MOLM-14 leukemic cells To mechanistically understand the regulation of the crosstalk between UPS and ALS in leukaemia, we investigated the role of proteaphagy ...
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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease
... of 26S proteasome Monolayers were infected for 3 h at an MOI of 100 or 200 bac- teria per cell and washed twice with ice-cold PBS and then scraped in ice-cold HEPES buffered saline (150 mmol/L NaCl, 5 ...
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Identification et caractérisation de nouveaux facteurs d'assemblage du protéasome 26S chez la levure Saccharomyces cerevisiae
... the 26S proteasome, the central enzyme of ubiquitin- dependant proteolysis that plays crucial roles in most essential cellular ...processes. Proteasome is a highly sophisticated macromolecular ...
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Analysis of the proteasome-autophagy crosstalk under proteotoxic stress conditions in acute myeloid leukemia
... after proteasome inhibition in FLT3-ITD mutant driven MOLM-14 leukemic cells To mechanistically understand the regulation of the crosstalk between UPS and ALS in leukaemia, we investigated the role of proteaphagy ...
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Evolution of Proteasome Regulators in Eukaryotes
... 20S proteasome, a specialized barrel-shaped and compartmentalized multicatalytic ...the 26S proteasome and allows the efficient degradation of proteins usually labeled by ubiquitin tags, PA200 and ...
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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome
... 20S/26S proteasome ratio most likely emerged to help cells contend with perturbations that cause protein ...the proteasome ( Deriziotis et ...20S proteasome inhibitors that are elaborated by ...
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BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1.
... the proteasome subunit PSMB1 To further identify BCL-3-interacting partners involved in its K48-degradative polyubiquitination, yeast-two-hybrid experiments were conducted using the N-terminal domain of BCL-3 ...
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Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome
... CHX or MG-132 and proteins visualized by western-blotting as indicated. (C) Following transfection with HA-eIF4GII (top), HA-DAP5 (middle), or HA-eIF4GII-C (bottom) cDNAs, NIH-3T3 cells were untreated or treated at ...
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Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome.
... Results: We report here that USP2 and USP34/Puf, in addition to the previously described USP36/Scny, prevent inappropriate activation of Imd-dependent immune signal in unchallenged conditions. Moreover, USP34 is also ...
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The ubiquitin-proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle atrophy
... ubiquitin- proteasome and the mitochondria-associated apoptotic pathways are sequentially downregulated during recovery after immobilization-induced muscle ...the proteasome were detectable from I6 to ...
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Manipulation of the ubiquitin-proteasome system by HIV-1 : role of the accessory protein Vpr
... degraded by the proteasome given that this type of homopolymeric ubiquitin chain generally leads to proteasomal proteolysis [55,56]. Several investigators reported that Vpr activates ATR in a variety of cell ...
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Proteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human islets
... whether proteasome dysfunction could be involved in beta cell apoptosis in glucotoxic conditions, and to evaluate whether such a dysfunction might be pharmacologically ...three proteasome activities by 20% ...
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The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
... active proteasome is a major characteristic of apoptotic exosome-like vesicle, we evaluated if healthy endothelial cells could also secrete membrane vesicles containing active 20S ...20S proteasome core ...
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