RIG-I-like receptors
MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I Interferon production after activation of the antiviral RIG-I-Like receptors.
... of RIG-I but not of MDA-5 ...by RIG-I [9] (Figure 4B) and, thus, we noticed that transfection of TRIM25 aug- ments activation of the IFNb promoter once cells are stimulated (Figure ...of ...
14
Recognition of hepatitis C virus RNA by toll like receptors 7 and 8 : implications for the initiation of innate immune response
... 12 alpha) to eliminate self-replicating subgenomic RNA within the cells. Huh7.5 appears highly permissive for HCV infection and replication. A single point mutation was observed in the dsRNA sensor RIG-I ...
195
Reconnaissance moléculaire du virus Epstein-Barr par les "Toll-like receptors"
... ces deux récepteurs a aussi été étudiée dans un modèle in vivo suite à l'infection par HSV-2 de souris déficientes pour le TLR2 et le TLR9 [162]. L'étude a clairement établi que la présence des deux TLRs augmentait la ...
144
Biologic modulation of ionizing radiation by Toll-like receptors agonists: Towards an increase in the therapeutic index of radiotherapy?
... souvent des nucléotides [2]. Après fixation du ligand, le récepteur recrute alors des adaptateurs intracellulaires, notamment le Myeloid Differenciation factor de 88 kDa (MyD88), qui entraînent une cascade de ...
15
RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans
... to extended starvation by increased sleep and developmental arrest to prolong healthy lifespan 83 . In adult C. ele- gans, however, food deprivation also leads to suppression of heat stress-induced quiescence and this ...
16
PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons.: IGF-1 transactivates PACAP type I receptors
... Gs-coupled receptors can induce a rapid transactivation of the epidermal growth factor receptor (EGFR) through a signalling cascade involving cAMP and PKA (Bertelsen et ...PACAP, like IGF-1, stimulated the ...
35
Dopamine D2-Like Receptors Modulate Intrinsic Properties and Synaptic Transmission of Parvalbumin Interneurons in the Mouse Primary Motor Cortex
... in DPX (Sigma-Aldrich). Confocal microscopy and image analysis were conducted at the Montpellier RIO Imaging Facility. All images covering the M1 region were single confocal sections acquired using sequential laser scan- ...
12
Motion of an uncalibrated stereo rig : self-calibration and metric reconstruction
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
13
Commissioning of a high speed rolling-element bearing rig: preliminary results
... Bearing rig drive system Figure ...test rig, the inner ring of the bearing under test is mounted on a hub, which engages with the shaft by a self-releasing ...test rig as a single unit using a custom ...
4
Role of type I receptors for anti-Müllerian hormone in the SMAT-1 Sertoli cell line
... DNA constructs The influenza virus HA-tagged ALKs and kinase- deficient mutant human ALK6-K231R (ALK6-KD) were provided by Dr J Massague´ (New York). Human ALK2 and ALK3 cDNAs from pCMV5 were cloned into BamHI/HindIII ...
9
Altered expression of type I insulin-like growth factor receptor in Crohn's disease
... Summary The fibrotic and antiapoptotic effects of insulin-like growth factors (IGF) are mediated by type I IGR receptor (IGF-1R). IGFs could play a role in intestinal stricturing and in the maintenance of ...
9
Designer Lipid-Like Peptides: A Class of Detergents for Studying Functional Olfactory Receptors Using Commercial Cell-Free Systems
... olfactory receptors nearly overlapped, indicating that the peptides were able to aid in the proper folding of expressed olfactory receptors equally as well as ...
10
Implication de l’Insulin-like Growth Factor (IGF-I), secrété par le microenvironnement tumoral, dans la survie et la chimiorésistance des cellules cancéreuses
... 83 Introduction The tumor microenvironment has been largely studied as a dynamic system orchestrated by several growth factor as Insulin like Growth Factor-I (IGF-I) (Uchiyama et al, 1993; Chauhan ...
162
Electrophysiology of ionotropic GABA receptors
... transmission, followed by the progressive closure of the chan- nels when protons and GABA are cleared from the synaptic cleft. NMDA, the glutamate receptor mediating most of the excit- atory signals in the central ...
31
Chemokine receptors in allergic diseases
... Chemokine receptors belong to the super family of G-protein-coupled receptors (GPCRs), and they represent good candidates for drug ...these receptors (93). Many receptors have been targeted, ...
10
Death receptors as targets in cancer
... L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignemen[r] ...
4
General molecular biology and architecture of nuclear receptors.: Transcriptional regulation by nuclear receptors
... b.3. The mediator complex: Like the SWI/SNF complex, the Mediator complex has been originally identified in yeast and subsequently characterized in other eukaryotic cells. A number of studies described its role as ...
65
Family physicians’ perceptions toward writing physical activity prescriptions: I tell patients it’s like the super pill!
... Phase I: Web-based survey In Phase I, 387 physicians listed in a provincial medical training program mailing list were invited to take part in a web- based survey to assess whether they were prescribing ...
9
Advanced burner-rig test for oxidation-corrosion resistance evaluation of MCrAlY/superalloys systems
... Depletion zones at the coating/oxide and coating/substrate interfaces have almost the same thickness in isothermal oxidation tests, whereas the internal oxidation zone is thicker than the diffusion zone in the ...
17
Design and Calibration of a Specialized Polydioptric Camera Rig
... camera rig (distance between the centers of the left and right fisheye lens) is measured, and two parallel lines with the same distance to each other as well as a center line are drawn on a ...The rig is ...
11