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retinoic acid receptor

Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α

Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α

... the retinoic acid receptors (RAR) and the retinoid X receptors (RXR), which have distinct cellular functions and are expressed in a variety of tissues including the kidney 12 ...trans-retinoic ...

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Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering

Evolutionary diversification of retinoic acid receptor ligand-binding pocket structure by molecular tinkering

... Japanese lamprey RAR1 Australian lamprey RAR1 Figure 5. Calculation of ancestral retinoic acid receptor (RAR) sequences of vertebrates. (a) Phylogenetic tree of deuterostome RARs. The species ...

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Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling

Retinoic acid receptor α as a novel contributor to adrenal cortex structure and function through interactions with Wnt and Vegfa signalling

... which was higher in APA_A compared to APA_B (Fig. 1D ). The three groups were pairwise compared to obtain a list of statistically significantly differentially expressed genes for each of the three comparisons ...

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An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist

... Introduction Retinoic acids and their analogs, referred to as retinoids, exert their pleiotropic effects through three retinoic acid receptor subtypes [RAR α (NR1B1), RARβ (NR1B2) and RARγ ...

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Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

... SUPPLEMENTARY INFORMATION FOR Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression Tiago N. Cordeiro 1,2 , Nathalie Sibille 1 , Pierre ...

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Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue

Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue

... and retinoic acid response element signaling was selectively observed in WAT of mice fed a normal–vitamin A, high-fat ...synthetic retinoic acid receptor (RAR)a- and RARg-selective ...

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Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

... Endogenous Retinoic Acid Re- ceptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regu- lating Retinoid-responsive Elements in Adult Human Keratinocytes.[r] ...

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PLZF is a negative regulator of retinoic acid receptor transcriptional activity.

PLZF is a negative regulator of retinoic acid receptor transcriptional activity.

... amino acid (AA) transcriptional repressor belonging to a large protein family characterized by a 120 AA N-terminal bric-à-brac, tramtrack, brad complex (BTB)/poxvirus zinc finger (POZ) ...

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en fr Nuclear retinoic acid receptor alpha (RARα) : novel unconventional non-genomic effects and novel partners Le récepteur nucléaire de l'acide rétinoïque alpha (RARa) : nouveaux effets non-génomiques et nouveaux partenaires

... aberrant receptor tyrosine kinase expression and/or activity (exemplified by erbB-2 breast cancers), the formation of RARa/Gaq complexes is suppressed, resulting in the abrogation of the non- genomic effects of RA, ...

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MEIOSIS INITIATES IN THE FETAL OVARY OF MICE LACKING ALL RETINOIC ACID RECEPTOR ISOTYPES

MEIOSIS INITIATES IN THE FETAL OVARY OF MICE LACKING ALL RETINOIC ACID RECEPTOR ISOTYPES

... expressing SYCP3 (green nuclear signal): in both control (A) and mutant (B) ovaries, 667. almost all germ cells express SYCP3 at high levels; exceptions (i.e, cells expressing 668[r] ...

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The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

... 10 of the transcriptional activity measured for human RARa at nanomolar retinoid concentrations (8). Our structural analyses established that PduRAR accommodates ATRA via a binding mode that is different from the one ...

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Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing

Lysyl oxidase-like 4 involvement in retinoic acid epithelial wound healing

... as a gene regulator. The LOXL4 regulation by atRA involved nuclear retinoic acid receptor RARα fixation on the second DR5 in LOXL4 promoter (− 4122, − 4146 pb). Furthermore, we found that this gene ...

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Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review

Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review

... 3.1. Retinoic Acid Receptor α (RARα) It has been demonstrated that ATRA is a RARα ligand, and that a specific antagonist of RARα can counteract ATRA’s effect [ 50 , 51 ] (Table 1 ...

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Function of retinoic acid receptors during embryonic development.

Function of retinoic acid receptors during embryonic development.

... nuclear receptor; PHPV: persistent and hyperplastic vitreous body; POM: periocular mesenchyme; R1 to R7: rhombomeres 1 to 7; RA: retinoic acid; RALDH: retinaldehyde dehydrogenase; RAR: ...

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Crosstalk between retinoic acid and sex-related genes controls germ cell fate and gametogenesis in Medaka

Crosstalk between retinoic acid and sex-related genes controls germ cell fate and gametogenesis in Medaka

... Efimenko et al., 2013 ). In addition, gata4 was proposed to be important for gonadal development and maturation in both sexes of Tilapia ( Li et al., 2012 ). Analyzes in vitro demonstrated that Gata4 is upregulated in ...

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Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary

Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary

... All-trans retinoic acid (ATRA) signaling is considered the key pathway that promotes Stra8 (stimulated by retinoic acid 8) expression and, in turn, meiosis ...

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Collecting duct cells show differential retinoic acid responses to acute versus chronic kidney injury stimuli

Collecting duct cells show differential retinoic acid responses to acute versus chronic kidney injury stimuli

... LacZ mice, Adriamycin-induced heavy albuminuria was associated with reduced RA/RAR activity in CD cells. In cultured CD cells, RA/RAR activity was repressed by acetylcholine, albumin, aldosterone, angiotensin II, high ...

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Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.

Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.

... Peri Ocular Mesenchyme) whereas RAR! would be the only receptor located in the developing retina and the retinal pigmented epithelium (RPE) (Mori et al., 2001). In order to verify this observation, we examined the ...

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Anti-tumour effect of an aromatic retinoic acid analog in a mouse syngeneic transplantable sarcoma

Anti-tumour effect of an aromatic retinoic acid analog in a mouse syngeneic transplantable sarcoma

... Tumour complete regression rate and median survival time of progressors mice are significantly improved.. These results are at variance with previous observations suggesting the lack of [r] ...

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Retinoic acid signaling pathways

Retinoic acid signaling pathways

... Kondoh, H. and Takemoto, T. (2012). Axial stem cells deriving both posterior neural and mesodermal tissues during gastrulation. Curr. Opin. Genet. Dev. 22, 374-380. doi:10.1016/j.gde.2012.03.006 Krezel, W., Ghyselinck, ...

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